| UniProt ID | ASB9_HUMAN | |
|---|---|---|
| UniProt AC | Q96DX5 | |
| Protein Name | Ankyrin repeat and SOCS box protein 9 | |
| Gene Name | ASB9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 294 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.. | |
| Protein Sequence | MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDGKQGGM -------CCCCCCCC | 16.10 | 22814378 | |
| 11 | Phosphorylation | KQGGMDGSKPAGPRD CCCCCCCCCCCCCCC | 31.07 | - | |
| 51 | Phosphorylation | AIHGHQLSLRNLISQ HHHCHHHHHHHHHHC | 20.79 | 14702039 | |
| 165 | Phosphorylation | GNIDHKISHLGTPLY CCCCHHHHCCCCCHH | 19.91 | 23312004 | |
| 169 | Phosphorylation | HKISHLGTPLYLACE HHHHCCCCCHHHHCC | 19.24 | 23312004 | |
| 172 | Phosphorylation | SHLGTPLYLACENQQ HCCCCCHHHHCCHHH | 8.08 | 23312004 | |
| 185 | Ubiquitination | QQRACVKKLLESGAD HHHHHHHHHHHCCCC | 37.60 | - | |
| 201 | Phosphorylation | NQGKGQDSPLHAVAR CCCCCCCCHHHHHHH | 22.82 | 25159151 | |
| 209 | Phosphorylation | PLHAVARTASEELAC HHHHHHHHHCHHHHH | 25.46 | 29759185 | |
| 211 | Phosphorylation | HAVARTASEELACLL HHHHHHHCHHHHHHH | 30.87 | 29759185 | |
| 225 | Phosphorylation | LMDFGADTQAKNAEG HHHCCCCCCCCCCCC | 29.87 | 25278378 | |
| 243 | Phosphorylation | VELVPPESPLAQLFL CEECCCCCHHHHHHH | 30.87 | 25850435 | |
| 246 (in isoform 3) | Phosphorylation | - | 13.86 | 25954137 | |
| 256 (in isoform 2) | Phosphorylation | - | 51.45 | 25954137 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASB9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASB9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASB9_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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