APBB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APBB3_HUMAN
• UniProt AC: O95704
• Protein Name: Amyloid-beta A4 precursor protein-binding family B member 3
• Gene Name: APBB3
• Organism: Homo sapiens (Human).
• Sequence Length: 486
• Subcellular Localization: Cytoplasm . Nucleus .; Isoform I-214: Nucleus.; Isoform I-245: Nucleus.
• Protein Description: May modulate the internalization of amyloid-beta precursor protein..
• Protein Sequence: MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKPSLLHMP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Phosphorylation	RSFSSLESSLDRSNS CCCHHHHHHCCCCCC	41.30	30576142
93	Phosphorylation	SFSSLESSLDRSNSL CCHHHHHHCCCCCCC	25.55	30576142
107	Phosphorylation	LSWYGGESYIQSMEP CCCCCCHHHHHCCCC	30.70	30576142
138 (in isoform 4)	Ubiquitination	-	39.71	-
138	Ubiquitination	EEDLAPGKSSIAVNN HHHCCCCCHHHHHHH	39.71	-
176 (in isoform 4)	Ubiquitination	-	47.47	-
207 (in isoform 4)	Ubiquitination	-	60.71	-
285	Phosphorylation	VELLDAVSQAAQKYE HHHHHHHHHHHHHHH	18.80	23401153
291	Phosphorylation	VSQAAQKYEALYMGT HHHHHHHHHHHHCCC	8.38	19702290
295	Phosphorylation	AQKYEALYMGTLPVT HHHHHHHHCCCCCCH	10.68	28509920
298	Phosphorylation	YEALYMGTLPVTKAM HHHHHCCCCCCHHHH	16.03	28509920
438	Phosphorylation	ARLRLKRTSSMDSPG HHHHCCCCCCCCCCC	24.46	28348404
439	Phosphorylation	RLRLKRTSSMDSPGG HHHCCCCCCCCCCCC	27.91	28348404
440	Phosphorylation	LRLKRTSSMDSPGGP HHCCCCCCCCCCCCC	26.46	28348404
443	Phosphorylation	KRTSSMDSPGGPLPL CCCCCCCCCCCCCCC	19.46	28348404
454	Ubiquitination	PLPLPLLKGGVGGAG CCCCCCCCCCCCCCC	62.39	-
461 (in isoform 4)	Ubiquitination	-	33.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APBB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APBB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APBB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	10081969
APLP1_HUMAN	APLP1	physical	10081969
APLP2_HUMAN	APLP2	physical	10081969
EGFR_HUMAN	EGFR	physical	16273093
ERBB2_HUMAN	ERBB2	physical	16273093
PDPK1_HUMAN	PDPK1	physical	25814554
RHBT1_HUMAN	RHOBTB1	physical	28514442
RHBT2_HUMAN	RHOBTB2	physical	28514442
APLP1_HUMAN	APLP1	physical	28514442
APLP2_HUMAN	APLP2	physical	28514442
A4_HUMAN	APP	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
CSN7B_HUMAN	COPS7B	physical	28514442
CSN3_HUMAN	COPS3	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
CSN5_HUMAN	COPS5	physical	28514442
UBB_HUMAN	UBB	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
CSN1_HUMAN	GPS1	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
HGFA_HUMAN	HGFAC	physical	28514442
BLK_HUMAN	BLK	physical	28514442
PSMG3_HUMAN	PSMG3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.