RHBT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHBT1_HUMAN
• UniProt AC: O94844
• Protein Name: Rho-related BTB domain-containing protein 1
• Gene Name: RHOBTB1
• Organism: Homo sapiens (Human).
• Sequence Length: 696
• Protein Sequence: MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	CQEVLERSRDVVDEV HHHHHHHCCCCHHHH	24.37	-
77	Phosphorylation	RDVVDEVSVSLRLWD CCCHHHHHHEEEEHH	12.16	24719451
79	Phosphorylation	VVDEVSVSLRLWDTF CHHHHHHEEEEHHCC	10.56	24719451
97	Phosphorylation	HKDRRFAYGRSDVVV CCCCCCCCCCCCEEE	15.45	21712546
119	Ubiquitination	PNSLNHVKSMWYPEI CCCCHHHHHHHCHHH	27.35	21906983
352	Phosphorylation	QWKSSNKSLVEALGL HHHHCCHHHHHHHCC	41.73	28348404
398	Phosphorylation	SKRMGPMTVVRMDAS HHCCCCEEEEECCCC	20.98	-
480	Phosphorylation	NRIKECLSKGTFSDV HHHHHHHHCCCCCCE	40.47	22817900
483	Phosphorylation	KECLSKGTFSDVTFK HHHHHCCCCCCEEEE	24.57	22817900
485	Phosphorylation	CLSKGTFSDVTFKLD HHHCCCCCCEEEEEC	30.89	-
535	Phosphorylation	LPNINKISMQAVLDY CCCCCHHCHHHHHHH	13.37	22210691
542	Phosphorylation	SMQAVLDYLYTKQLS CHHHHHHHHHHCCCC	9.46	-
544	Phosphorylation	QAVLDYLYTKQLSPN HHHHHHHHHCCCCCC	12.98	22210691
679	Ubiquitination	KEDIALNKHRSRRKW HHHHCCHHCHHCCCC	41.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHBT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHBT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHBT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	18835386
CUL5_HUMAN	CUL5	physical	18835386
CUL3_HUMAN	CUL3	physical	23040068
LRC41_MOUSE	Lrrc41	physical	22709582
BPIA2_HUMAN	BPIFA2	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
CYTD_HUMAN	CST5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480 AND THR-483, ANDMASS SPECTROMETRY.
PubMed: 17287340