LRA25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRA25_HUMAN
• UniProt AC: Q8N5H3
• Protein Name: Leucine repeat adapter protein 25
• Gene Name: FAM89B
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Isoform 3: Cytoplasm . Cell projection, lamellipodium . Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium.
• Protein Description: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation..
• Protein Sequence: MNGLPSAEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGAANAGPAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSFCQDLSSSLHSDSSYPPDAGLSDDEEPPDASLPPDPPPLTVPQTHNARDQWLQDAFHISL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNGLPSAEAPGGA --CCCCCCCCCCCCC		-
28	Phosphorylation	PPLPRGLSGLLNASG CCCCCCHHHHHCCCC		27251275
34	Phosphorylation	LSGLLNASGGSWREL HHHHHCCCCCCHHHH		28348404
37	Phosphorylation	LLNASGGSWRELERV HHCCCCCCHHHHHHH		28348404
46	Phosphorylation	RELERVYSQRSRIHD HHHHHHHHHHHHHHH		-
104 (in isoform 1)	Phosphorylation	-		28450419
106	Phosphorylation	GLRQLDMSLLCQLWG CCHHHCHHHHHHHHH		23663014
115	Phosphorylation	LCQLWGLYESIQDYK HHHHHHHHHHHHHHH		23663014
117	Phosphorylation	QLWGLYESIQDYKHL HHHHHHHHHHHHHHH		23663014
121	Phosphorylation	LYESIQDYKHLCQDL HHHHHHHHHHHHHHH		23663014
175	Phosphorylation	LTVPQTHNARDQWLQ CCCCCCCCCHHHHHH		20068231
188	Phosphorylation	LQDAFHISL------ HHHHHCCCC------		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRA25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRA25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRA25_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRA25_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.