MAZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAZ_HUMAN
• UniProt AC: P56270
• Protein Name: Myc-associated zinc finger protein
• Gene Name: MAZ
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Nucleus . In brains of Alzheimer disease patients, present in a plaque-like structures.
• Protein Description: May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins..
• Protein Sequence: MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQVGAELQSRFFASQGCAQSPFQAAPAPPPTPQAPAAEPLQVDLLPVLAAAQESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPPPPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSVPQLSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYHLNRHKLSHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSHCGKSFSRPDHLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHVCELCNKGTGEVCPMAAAAAAAAAAAAAAVAAPPTAVGSLSGAEGVPVSSQPLPSQPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	AAPAPPPTPQAPAAE CCCCCCCCCCCCCCC	33.53	11809795
73	Ubiquitination	APAPPPTPQAPAAEP CCCCCCCCCCCCCCC	33.82	-
73	Acetylation	APAPPPTPQAPAAEP CCCCCCCCCCCCCCC	33.82	-
178	Phosphorylation	VAVAPVASALEKKTK HHHHHHHHHHHHHHC	33.35	21964256
190	Phosphorylation	KTKSKGPYICALCAK HHCCCCCEEHHHHHH	19.80	28152594
213	Phosphorylation	RRHEAIHTGAKAGRV CCHHHHHHCCCCCCC	32.49	24719451
213 (in isoform 2)	Phosphorylation	-	32.49	24719451
216	Ubiquitination	EAIHTGAKAGRVPSG HHHHHCCCCCCCCCC	53.36	-
222	Phosphorylation	AKAGRVPSGAMKMPT CCCCCCCCCCCCCCC	36.01	24719451
222 (in isoform 2)	Phosphorylation	-	36.01	24719451
229	Phosphorylation	SGAMKMPTMVPLSLL CCCCCCCCCEEHHHH	27.57	24905233
234	Phosphorylation	MPTMVPLSLLSVPQL CCCCEEHHHHCCCCC	22.61	24905233
237	Phosphorylation	MVPLSLLSVPQLSGA CEEHHHHCCCCCCCC	36.72	24905233
242	Phosphorylation	LLSVPQLSGAGGGGG HHCCCCCCCCCCCCC	22.73	24905233
267	Phosphorylation	VAAGGVVTTTASGKR HHCCCEEEECCCCCC	18.94	24905233
268	Phosphorylation	AAGGVVTTTASGKRI HCCCEEEECCCCCCH	14.57	24905233
269	Phosphorylation	AGGVVTTTASGKRIR CCCEEEECCCCCCHH	14.95	24905233
271	Phosphorylation	GVVTTTASGKRIRKN CEEEECCCCCCHHHC	42.63	24905233
273	Acetylation	VTTTASGKRIRKNHA EEECCCCCCHHHCHH	42.00	30590295
286	Ubiquitination	HACEMCGKAFRDVYH HHHHHCCHHHHHHHH	39.15	-
298	Ubiquitination	VYHLNRHKLSHSDEK HHHHHCCCCCCCCCC	48.74	-
300 (in isoform 2)	Phosphorylation	-	26.25	27251275
300	Phosphorylation	HLNRHKLSHSDEKPY HHHCCCCCCCCCCCC	26.25	23927012
302 (in isoform 2)	Phosphorylation	-	44.05	24719451
302	Phosphorylation	NRHKLSHSDEKPYQC HCCCCCCCCCCCCCC	44.05	25159151
305	Ubiquitination	KLSHSDEKPYQCPVC CCCCCCCCCCCCCCH	54.75	-
305	Acetylation	KLSHSDEKPYQCPVC CCCCCCCCCCCCCCH	54.75	26051181
307 (in isoform 2)	Phosphorylation	-	33.54	27642862
307	Phosphorylation	SHSDEKPYQCPVCQQ CCCCCCCCCCCCHHH	33.54	23927012
321	Methylation	QRFKRKDRMSYHVRS HHHCCCCCCCEECCC	20.98	-
323	Phosphorylation	FKRKDRMSYHVRSHD HCCCCCCCEECCCCC	17.00	27251275
323 (in isoform 2)	Phosphorylation	-	17.00	24719451
324	Phosphorylation	KRKDRMSYHVRSHDG CCCCCCCEECCCCCC	8.59	27251275
335	Acetylation	SHDGAVHKPYNCSHC CCCCCCCCCCCCCCC	42.47	26051181
345	Phosphorylation	NCSHCGKSFSRPDHL CCCCCCCCCCCCHHH	17.46	28555341
347	Phosphorylation	SHCGKSFSRPDHLNS CCCCCCCCCCHHHHH	50.42	24719451
347 (in isoform 2)	Phosphorylation	-	50.42	24719451
354	Phosphorylation	SRPDHLNSHVRQVHS CCCHHHHHHHHHHHC	29.71	28555341
357	Methylation	DHLNSHVRQVHSTER HHHHHHHHHHHCCCC	27.64	115482727
361	Phosphorylation	SHVRQVHSTERPFKC HHHHHHHCCCCCCCC	32.86	25159151
361 (in isoform 2)	Phosphorylation	-	32.86	24719451
362	Phosphorylation	HVRQVHSTERPFKCE HHHHHHCCCCCCCCC	22.57	20068231
370	Acetylation	ERPFKCEKCEAAFAT CCCCCCCCCCHHEEC	47.01	25953088
378	Ubiquitination	CEAAFATKDRLRAHT CCHHEECHHHHHHHC	37.10	-
378	Acetylation	CEAAFATKDRLRAHT CCHHEECHHHHHHHC	37.10	23749302
385	Phosphorylation	KDRLRAHTVRHEEKV HHHHHHHCCCCCCCC	20.46	-
391	Acetylation	HTVRHEEKVPCHVCG HCCCCCCCCCHHHCC	48.79	25953088
402	Phosphorylation	HVCGKMLSSAYISDH HHCCHHHHHHHHHHC	14.93	27732954
403	Phosphorylation	VCGKMLSSAYISDHM HCCHHHHHHHHHHCC	22.56	27732954
405	Phosphorylation	GKMLSSAYISDHMKV CHHHHHHHHHHCCCH	11.69	27732954
407	Phosphorylation	MLSSAYISDHMKVHS HHHHHHHHHCCCHHC	14.59	27732954
411	Acetylation	AYISDHMKVHSQGPH HHHHHCCCHHCCCCH	33.12	25953088
414 (in isoform 2)	Phosphorylation	-	39.56	25159151
414	Phosphorylation	SDHMKVHSQGPHHVC HHCCCHHCCCCHHHH	39.56	28674419
428	Phosphorylation	CELCNKGTGEVCPMA HHHCCCCCCCCCHHH	31.60	21406692
454	Phosphorylation	AAVAAPPTAVGSLSG HHHHCCCCCCCCCCC	32.68	23663014
458	Phosphorylation	APPTAVGSLSGAEGV CCCCCCCCCCCCCCC	16.86	23663014
460	Phosphorylation	PTAVGSLSGAEGVPV CCCCCCCCCCCCCCC	37.34	23663014
468	Phosphorylation	GAEGVPVSSQPLPSQ CCCCCCCCCCCCCCC	19.72	23663014
469	Phosphorylation	AEGVPVSSQPLPSQP CCCCCCCCCCCCCCC	35.73	23663014
474	Phosphorylation	VSSQPLPSQPW---- CCCCCCCCCCC----	57.46	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
72	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
385	T	Phosphorylation	Kinase	AKT1	P31749	PSP
460	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
469	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
469	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BPTF_HUMAN	BPTF	physical	10727212
DCC_HUMAN	DCC	physical	11527412
FOS_HUMAN	FOS	physical	19028685
JUN_HUMAN	JUN	physical	19028685
APOD_HUMAN	APOD	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.