CR3L4_HUMAN - dbPTM
CR3L4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CR3L4_HUMAN
UniProt AC Q8TEY5
Protein Name Cyclic AMP-responsive element-binding protein 3-like protein 4
Gene Name CREB3L4
Organism Homo sapiens (Human).
Sequence Length 395
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type II membrane protein. Golgi apparatus membrane
Single-pass type II membrane protein . May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4:
Protein Description Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity)..
Protein Sequence MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51UbiquitinationEQGLQGWKSGGDRGC
HHCCCCHHCCCCCCC		46.1521906983
63PhosphorylationRGCGLQESEPEDFLK
CCCCCCCCCCHHHHH		45.5527251275
87PhosphorylationCSEASPGSDSGISED
ECCCCCCCCCCCCCC		31.8028348404
100PhosphorylationEDPCHPDSPPAPRAT
CCCCCCCCCCCCCCC		36.9228348404
107PhosphorylationSPPAPRATSSPMLYE
CCCCCCCCCCCCHHH		30.8927732954
108PhosphorylationPPAPRATSSPMLYEV
CCCCCCCCCCCHHHH		31.3127732954
109PhosphorylationPAPRATSSPMLYEVV
CCCCCCCCCCHHHHH		15.2427732954
113PhosphorylationATSSPMLYEVVYEAG
CCCCCCHHHHHHHHH		10.6327732954
117PhosphorylationPMLYEVVYEAGALER
CCHHHHHHHHHHHHH		12.7721253578
192UbiquitinationQTLFLTDEEKRLLGQ
EEEEECHHHHHHHCC		61.2529967540
194UbiquitinationLFLTDEEKRLLGQEG
EEECHHHHHHHCCCC		46.42-
203PhosphorylationLLGQEGVSLPSHLPL
HHCCCCCCCCCCCCC		45.4824719451
212UbiquitinationPSHLPLTKAEERVLK
CCCCCCCHHHHHHHH		62.5829967540
218UbiquitinationTKAEERVLKKVRRKI
CHHHHHHHHHHHHHH		5.7929967540
219UbiquitinationKAEERVLKKVRRKIR
HHHHHHHHHHHHHHH		46.4929967540
238UbiquitinationAQDSRRRKKEYIDGL
HHHHHHHHHHHHHHH		48.4129967540
239UbiquitinationQDSRRRKKEYIDGLE
HHHHHHHHHHHHHHH		54.6729967540
241UbiquitinationSRRRKKEYIDGLESR
HHHHHHHHHHHHHHH		17.1222505724
261UbiquitinationAQNQELQKKVQELER
HHHHHHHHHHHHHHH		68.4822505724
262UbiquitinationQNQELQKKVQELERH
HHHHHHHHHHHHHHC		35.87-
339O-linked_GlycosylationVTSRNILTHKDVTEN
CCCCCCCCCHHHHHC		24.0755823753
341UbiquitinationSRNILTHKDVTENLE
CCCCCCCHHHHHCHH		48.97-
344O-linked_GlycosylationILTHKDVTENLETQV
CCCCHHHHHCHHHHH		29.3255823759
349O-linked_GlycosylationDVTENLETQVVESRL
HHHHCHHHHHHHHHH		29.8155823765
354O-linked_GlycosylationLETQVVESRLREPPG
HHHHHHHHHHCCCCC		25.6355823769
366N-linked_GlycosylationPPGAKDANGSTRTLL
CCCCCCCCCCHHHHH		55.89UniProtKB CARBOHYD
368PhosphorylationGAKDANGSTRTLLEK
CCCCCCCCHHHHHHH		17.96-
369PhosphorylationAKDANGSTRTLLEKM
CCCCCCCHHHHHHHC		29.13-
375AcetylationSTRTLLEKMGGKPRP
CHHHHHHHCCCCCCC		42.707377613
383PhosphorylationMGGKPRPSGRIRSVL
CCCCCCCCCCCCEEE		41.8224719451
388PhosphorylationRPSGRIRSVLHADEM
CCCCCCCEEEECCCC		27.0227251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CR3L4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CR3L4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CR3L4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CREM_HUMANCREMphysical
16595651
LRC4C_HUMANLRRC4Cphysical
21988832
GANAB_HUMANGANABphysical
21988832
S19A3_HUMANSLC19A3physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CR3L4_HUMAN

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Related Literatures of Post-Translational Modification

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