LRC4C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC4C_HUMAN
• UniProt AC: Q9HCJ2
• Protein Name: Leucine-rich repeat-containing protein 4C
• Gene Name: LRRC4C
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein .
• Protein Description: May promote neurite outgrowth of developing thalamic neurons..
• Protein Sequence: MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	AGLVRAQTCPSVCSC HHHHHHCCCCCHHHC	25.96	-
54	Phosphorylation	CPSVCSCSNQFSKVI CCCHHHCCCCCCEEE	19.85	-
173	Phosphorylation	YAFNRIPSLRRLDLG HHHCCCCCCCCCCHH	31.94	24719451
197	Phosphorylation	EGAFEGLSNLRYLNL CCCCCCCCCHHHHHH	44.68	24719451
216	Phosphorylation	LREIPNLTPLIKLDE CCCCCCCCCCEECEE	23.76	24505115
317	Sumoylation	LWLSWWIKDMAPSNT EEEEHHHHHCCCCCC	27.94	-
324	Phosphorylation	KDMAPSNTACCARCN HHCCCCCCCCHHHCC	25.96	-
383	Phosphorylation	RASTSLTSVSWITPN CCCCCCCEEEEECCC	21.32	22210691
392	Phosphorylation	SWITPNGTVMTHGAY EEECCCCEEEECCEE	17.47	22210691
395	Phosphorylation	TPNGTVMTHGAYKVR CCCCEEEECCEEEEE	16.90	22210691
537	Phosphorylation	IGCFVAITLMAAVML HHHHHHHHHHHHHHH	10.76	-
548	Phosphorylation	AVMLVIFYKMRKQHH HHHHHHHHHHHHHHH	7.86	19835603
603	Phosphorylation	NHYNSYKSPFNHTTT CCCCCCCCCCCCCCC	26.87	-
610	Phosphorylation	SPFNHTTTVNTINSI CCCCCCCCHHHHHHH	16.95	-
616	Phosphorylation	TTVNTINSIHSSVHE CCHHHHHHHCCCCCC	20.16	-
631	Phosphorylation	PLLIRMNSKDNVQET CEEEECCCCCCCCCC	31.85	30266825
638	Phosphorylation	SKDNVQETQI----- CCCCCCCCCC-----	17.93	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
631	S	Phosphorylation	Kinase	CDKL5	O76039	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC4C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC4C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRC4B_HUMAN	LRRC4B	physical	28514442
LRRC4_HUMAN	LRRC4	physical	28514442
VLDLR_HUMAN	VLDLR	physical	28514442
SULF1_HUMAN	SULF1	physical	28514442
SULF2_HUMAN	SULF2	physical	28514442
DVL2_HUMAN	DVL2	physical	28514442
MTMR5_HUMAN	SBF1	physical	28514442
UBE2S_HUMAN	UBE2S	physical	28514442
NCOA5_HUMAN	NCOA5	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
NOB1_HUMAN	NOB1	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
S39AB_HUMAN	SLC39A11	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442
MTMR1_HUMAN	MTMR1	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
CNPY3_HUMAN	CNPY3	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
BRI3B_HUMAN	BRI3BP	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.