LRRC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRC4_HUMAN
• UniProt AC: Q9HBW1
• Protein Name: Leucine-rich repeat-containing protein 4
• Gene Name: LRRC4
• Organism: Homo sapiens (Human).
• Sequence Length: 653
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. LRRC4 and DLG4 are interdependent for synaptic localization..
• Protein Description: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity)..
• Protein Sequence: MKLLWQVTVHHHTWNAILLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	GIPSNTRYLNLMENN CCCCCCHHHHHHHHC	9.63	22210691
94	Phosphorylation	IQMIQADTFRHLHHL EEEEEHHCHHHHHHH	26.11	22210691
172	Phosphorylation	YAFNRVPSLMRLDLG HHHCCCCCCEECCHH	31.76	-
186	Phosphorylation	GELKKLEYISEGAFE HHHCCCEEECCCCCH	21.86	-
242	Phosphorylation	PGSFHGLSSLKKLWV CCCCCCHHHHHHHHH	37.91	24719451
277	N-linked_Glycosylation	ELNLAHNNLSSLPHD HHHHHCCCHHHCCCC	31.28	UniProtKB CARBOHYD
322	N-linked_Glycosylation	LREYIPTNSTCCGRC HHHHCCCCCCCCCCC	29.93	UniProtKB CARBOHYD
363	N-linked_Glycosylation	MDAPRDLNISEGRMA EECCCCCCCCCCCCE	39.78	UniProtKB CARBOHYD
388	N-linked_Glycosylation	SVKWLLPNGTVLSHA CCEEECCCCCCCCCC	59.75	UniProtKB CARBOHYD
410	N-linked_Glycosylation	VLNDGTLNFSHVLLS EECCCCEEECEEEEC	35.89	UniProtKB CARBOHYD
434	N-linked_Glycosylation	TNVAGNSNASAYLNV EEECCCCCCEEEEEE	41.75	UniProtKB CARBOHYD
440	N-linked_Glycosylation	SNASAYLNVSTAELN CCCEEEEEECCCEEC	17.02	UniProtKB CARBOHYD
447	N-linked_Glycosylation	NVSTAELNTSNYSFF EECCCEECCCCCCEE	32.73	UniProtKB CARBOHYD
450	N-linked_Glycosylation	TAELNTSNYSFFTTV CCEECCCCCCEEEEE	34.13	UniProtKB CARBOHYD
478	Phosphorylation	RKYKPVPTTSTGYQP CCCCCCCCCCCCCCC	33.34	-
479	Phosphorylation	KYKPVPTTSTGYQPA CCCCCCCCCCCCCCC	20.44	-
480	Phosphorylation	YKPVPTTSTGYQPAY CCCCCCCCCCCCCCE	23.47	-
488	Phosphorylation	TGYQPAYTTSTTVLI CCCCCCEECCEEEEE	19.17	-
558	Phosphorylation	RKRHQQRSTVTAART HHHHHHCCCCEEEEE	23.92	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F1142_HUMAN	FAM114A2	physical	28514442
TBCD_HUMAN	TBCD	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
DPP9_HUMAN	DPP9	physical	28514442
CIP2A_HUMAN	KIAA1524	physical	28514442
POMT2_HUMAN	POMT2	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
TRI18_HUMAN	MID1	physical	28514442
ITB5_HUMAN	ITGB5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.