S19A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S19A3_HUMAN
• UniProt AC: Q9BZV2
• Protein Name: Thiamine transporter 2
• Gene Name: SLC19A3
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity..
• Protein Sequence: MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	N-linked_Glycosylation	YLSGPDKNLTSAEIT HCCCCCCCCCHHHHC	56.80	19159218
151	Phosphorylation	RSVTLAAYTAGSVLA HHHHHHHHHHHHHHH	7.48	-
152	Phosphorylation	SVTLAAYTAGSVLAQ HHHHHHHHHHHHHHH	21.59	-
166	N-linked_Glycosylation	QLLVSLANMSYFYLN HHHHHHHCCCHHHHH	25.81	UniProtKB CARBOHYD
210	Phosphorylation	PSREIKKSSSVNPVL CCCHHHCCCCCCCCH	23.89	29978859
211	Phosphorylation	SREIKKSSSVNPVLE CCHHHCCCCCCCCHH	47.38	29978859
212	Phosphorylation	REIKKSSSVNPVLEE CHHHCCCCCCCCHHH	32.76	26657352
220	Phosphorylation	VNPVLEETHEGEAPG CCCCHHHCCCCCCCC	18.82	29978859
234	Phosphorylation	GCEEQKPTSEILSTS CCCCCCCCHHHHCCC	46.13	23312004
235	Phosphorylation	CEEQKPTSEILSTSG CCCCCCCHHHHCCCC	31.03	25002506
239	Phosphorylation	KPTSEILSTSGKLNK CCCHHHHCCCCCCCC	26.62	30242111
240	Phosphorylation	PTSEILSTSGKLNKG CCHHHHCCCCCCCCH	37.74	27251275
241	Phosphorylation	TSEILSTSGKLNKGQ CHHHHCCCCCCCCHH	30.47	22798277
472	Phosphorylation	KSQKDVQSPAPSENP CCCCCCCCCCCCCCC	23.91	28192239
476	Phosphorylation	DVQSPAPSENPDVSH CCCCCCCCCCCCCCC	52.71	28857561
482	Phosphorylation	PSENPDVSHPEEESN CCCCCCCCCCHHHHC	40.48	22210691
488	Phosphorylation	VSHPEEESNIIMSTK CCCCHHHHCCEEEEC	36.29	22210691
493	Phosphorylation	EESNIIMSTKL---- HHHCCEEEECC----	16.39	22210691
494	Phosphorylation	ESNIIMSTKL----- HHCCEEEECC-----	20.98	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S19A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S19A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S19A3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S19A3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H01231: Biotin-responsive basal ganglia disease (BBGD)
• OMIM Disease
• 607483: Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type (THMD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00151: L-Cysteine

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45, AND MASS SPECTROMETRY.
PubMed: 19159218