CLCN6_HUMAN - dbPTM
CLCN6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLCN6_HUMAN
UniProt AC P51797
Protein Name Chloride transport protein 6
Gene Name CLCN6
Organism Homo sapiens (Human).
Sequence Length 869
Subcellular Localization Endosome membrane
Multi-pass membrane protein . Detected in detergent-resistant lipid rafts.
Protein Description Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter..
Protein Sequence MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationCGERETRTPEELTIL
CCCCCCCCHHHHEEC		42.3324076635
30PhosphorylationTRTPEELTILGETQE
CCCHHHHEECCCCCC		19.8927732954
46 (in isoform 5)Ubiquitination-63.82-
46UbiquitinationEDEILPRKDYESLDY
CCCCCCCCCHHCCCH		63.8230230243
48 (in isoform 5)Phosphorylation-15.5127642862
53 (in isoform 5)Phosphorylation-15.5827642862
61PhosphorylationDRCINDPYLEVLETM
HHHCCCHHHHHHHHH		20.54-
190PhosphorylationKVLGVLFSVAGGLFV
HHHHHHHHHHCCEEE		13.59-
202UbiquitinationLFVEKEGPMIHSGSV
EEEECCCCCEECCCE		21.4621890473
219PhosphorylationAGLPQFQSISLRKIQ
CCCCCCEEEEEEEEE		18.5529496963
221PhosphorylationLPQFQSISLRKIQFN
CCCCEEEEEEEEEEC		27.6329496963
224 (in isoform 4)Ubiquitination-46.2621890473
224 (in isoform 3)Ubiquitination-46.2621890473
224 (in isoform 2)Ubiquitination-46.2621890473
224 (in isoform 1)Ubiquitination-46.2621890473
224UbiquitinationFQSISLRKIQFNFPY
CEEEEEEEEEECCCC		46.2621890473
224UbiquitinationFQSISLRKIQFNFPY
CEEEEEEEEEECCCC		46.2622817900
224 (in isoform 5)Ubiquitination-46.2621890473
296PhosphorylationFTLNFFRSGIQFGSW
EEEEHHHCCCCCCCC		34.7830624053
302PhosphorylationRSGIQFGSWGSFQLP
HCCCCCCCCCCCCCC		29.5630624053
305PhosphorylationIQFGSWGSFQLPGLL
CCCCCCCCCCCCCEE		11.9930624053
320PhosphorylationNFGEFKCSDSDKKCH
ECCEEECCCCCCCHH		40.5130624053
322PhosphorylationGEFKCSDSDKKCHLW
CEEECCCCCCCHHHH		34.7330624053
410N-linked_GlycosylationSSSSQIGNDSFQLQV
CCCCCCCCCCEEEEE		43.3017534424
422N-linked_GlycosylationLQVTEDVNSSIKTFF
EEEECCCCHHCEEEE		42.2217534424
423PhosphorylationQVTEDVNSSIKTFFC
EEECCCCHHCEEEEC		33.0324275569
424PhosphorylationVTEDVNSSIKTFFCP
EECCCCHHCEEEECC		23.9324275569
432N-linked_GlycosylationIKTFFCPNDTYNDMA
CEEEECCCCCCCCCH		56.2717534424
622UbiquitinationHTRIQSLVSILRTTV
HHHHHHHHHHHHHHH		3.9623000965
626UbiquitinationQSLVSILRTTVHHAF
HHHHHHHHHHHHHHC		27.0423000965
636UbiquitinationVHHAFPVVTENRGNE
HHHHCCEECCCCCCC		5.9029967540
644UbiquitinationTENRGNEKEFMKGNQ
CCCCCCCCCCCCCCC		61.3223000965
648 (in isoform 5)Ubiquitination-61.09-
648UbiquitinationGNEKEFMKGNQLISN
CCCCCCCCCCCEECC		61.0923000965
648MethylationGNEKEFMKGNQLISN
CCCCCCCCCCCEECC		61.09-
657UbiquitinationNQLISNNIKFKKSSI
CCEECCCCCCCHHHH		6.9333845483
658UbiquitinationQLISNNIKFKKSSIL
CEECCCCCCCHHHHH		53.9429967540
661PhosphorylationSNNIKFKKSSILTRA
CCCCCCCHHHHHHHH		53.2032142685
663PhosphorylationNIKFKKSSILTRAGE
CCCCCHHHHHHHHHH		30.4224719451
677PhosphorylationEQRKRSQSMKSYPSS
HHHHHHHHHCCCCHH		29.4422210691
679UbiquitinationRKRSQSMKSYPSSEL
HHHHHHHCCCCHHHH		52.6833845483
679 (in isoform 5)Ubiquitination-52.68-
680PhosphorylationKRSQSMKSYPSSELR
HHHHHHCCCCHHHHH		33.3730108239
681PhosphorylationRSQSMKSYPSSELRN
HHHHHCCCCHHHHHH		11.1330108239
681 (in isoform 5)Phosphorylation-11.1327642862
683PhosphorylationQSMKSYPSSELRNMC
HHHCCCCHHHHHHHH		28.3626699800
684PhosphorylationSMKSYPSSELRNMCD
HHCCCCHHHHHHHHH		35.8230108239
773PhosphorylationSASQPRLSYAEMAED
CCCCCCCCHHHHHHH		24.4727732954
774PhosphorylationASQPRLSYAEMAEDY
CCCCCCCHHHHHHHC		15.9227732954
784PhosphorylationMAEDYPRYPDIHDLD
HHHHCCCCCCHHHCC		10.76-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLCN6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLCN6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLCN6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLCN6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLCN6_HUMAN

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Related Literatures of Post-Translational Modification

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