PLLP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLLP_HUMAN
• UniProt AC: Q9Y342
• Protein Name: Plasmolipin
• Gene Name: PLLP
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity)..
• Protein Sequence: MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAEFPSKVSTRTS --CCCCCCCCCCCCC	51.51	28857561
7	Ubiquitination	-MAEFPSKVSTRTSS -CCCCCCCCCCCCCC	40.20	-
9	Phosphorylation	AEFPSKVSTRTSSPA CCCCCCCCCCCCCHH	18.86	28355574
10	Phosphorylation	EFPSKVSTRTSSPAQ CCCCCCCCCCCCHHC	40.74	23186163
12	Phosphorylation	PSKVSTRTSSPAQGA CCCCCCCCCCHHCCC	33.38	25850435
13	Phosphorylation	SKVSTRTSSPAQGAE CCCCCCCCCHHCCCC	30.91	26657352
14	Phosphorylation	KVSTRTSSPAQGAEA CCCCCCCCHHCCCCH	24.52	21082442
22	Phosphorylation	PAQGAEASVSALRPD HHCCCCHHHHHHCCC	14.22	23322592
24	Phosphorylation	QGAEASVSALRPDLG CCCCHHHHHHCCCHH	21.06	24719451
170	Phosphorylation	QAWRGVGSNAATSQM HHHCCCCCCHHHHHH	22.38	22461510
181	Phosphorylation	TSQMAGGYA------ HHHHCCCCC------	14.28	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLLP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLLP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLLP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M4A12_HUMAN	MS4A12	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.
PubMed: 18691976