M4A12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M4A12_HUMAN
• UniProt AC: Q9NXJ0
• Protein Name: Membrane-spanning 4-domains subfamily A member 12
• Gene Name: MS4A12
• Organism: Homo sapiens (Human).
• Sequence Length: 267
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: May be involved in signal transduction as a component of a multimeric receptor complex..
• Protein Sequence: MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPNMYESNPVTPASSSAPPRCNNYSANAPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	GIVLCLISFSFREVL HHHHHHHHCHHHHHH	11.24	24719451
115	Phosphorylation	VLCLISFSFREVLGF HHHHHHCHHHHHHCC	19.32	24719451
244	Phosphorylation	VIPNMYESNPVTPAS ECCCCCCCCCCCCCC	29.01	-
248	Phosphorylation	MYESNPVTPASSSAP CCCCCCCCCCCCCCC	17.88	-
261	Phosphorylation	APPRCNNYSANAPK- CCCCCCCCCCCCCC-	8.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M4A12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M4A12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M4A12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM3A_HUMAN	FAM3A	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.