ITPK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITPK1_HUMAN
• UniProt AC: Q13572
• Protein Name: Inositol-tetrakisphosphate 1-kinase
• Gene Name: ITPK1
• Organism: Homo sapiens (Human).
• Sequence Length: 414
• Protein Description: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain..
• Protein Sequence: MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKASSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Acetylation	VGYWLSEKKIKKLNF CCCCCCHHHHHHCCH	57.32	25953088
108	Ubiquitination	RTLLDRSKSYELIRK HHHHHHHHHHHHHHH	58.93	-
147	Ubiquitination	DTMRLLEKNGLTFPF HHHHHHHHCCCCCCE	57.17	-
198	Phosphorylation	INHNAVLYKVFVVGE CCCCEEEEEEEEECC	9.86	25332170
214	Phosphorylation	YTVVQRPSLKNFSAG EEEEECCCCCCCCCC	54.91	30266825
237	Ubiquitination	FNSHNVSKPESSSVL CCCCCCCCCCCCCHH	48.82	-
266	Phosphorylation	DEVIRELSRALRQAL HHHHHHHHHHHHHHH	15.68	-
330	Phosphorylation	QSTAMAATGDVALLR CHHHHHHHCCHHHHH	25.11	28787133
339	Phosphorylation	DVALLRHSKLLAEPA CHHHHHCHHHHCCCC	20.68	28857561
340	Acetylation	VALLRHSKLLAEPAG HHHHHCHHHHCCCCC	41.20	22308441
340	Ubiquitination	VALLRHSKLLAEPAG HHHHHCHHHHCCCCC	41.20	22308441
354	Phosphorylation	GGLVGERTCSASPGC CCCCCEEECCCCCCC	13.40	29978859
356	Phosphorylation	LVGERTCSASPGCCG CCCEEECCCCCCCCH	31.04	21815630
358	Phosphorylation	GERTCSASPGCCGSM CEEECCCCCCCCHHH	12.92	21815630
364	Phosphorylation	ASPGCCGSMMGQDAP CCCCCCHHHCCCCCC	7.53	28102081
383	Ubiquitination	ADAGGTAKLPHQRLG CCCCCCCCCCHHHCC	63.49	22308441
383	Acetylation	ADAGGTAKLPHQRLG CCCCCCCCCCHHHCC	63.49	22308441
396	Phosphorylation	LGCNAGVSPSFQQHC CCCCCCCCHHHHHHH	17.57	25159151
398	Phosphorylation	CNAGVSPSFQQHCVA CCCCCCHHHHHHHHH	28.34	28152594
406	Phosphorylation	FQQHCVASLATKASS HHHHHHHHHHHHHHC	9.72	28450419
409	Phosphorylation	HCVASLATKASSQ-- HHHHHHHHHHHCC--	32.22	28450419
410	Acetylation	CVASLATKASSQ--- HHHHHHHHHHCC---	40.44	22308441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITPK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITPK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITPK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	16189514
CSN1_HUMAN	GPS1	physical	12324474
P53_HUMAN	TP53	physical	12324474
JUN_HUMAN	JUN	physical	12324474
ITPK1_HUMAN	ITPK1	physical	12324474
IKBA_HUMAN	NFKBIA	physical	12324474
QORL1_HUMAN	CRYZL1	physical	26186194
DAAF5_HUMAN	DNAAF5	physical	26344197
QORL1_HUMAN	CRYZL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.