AOC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AOC2_HUMAN
• UniProt AC: O75106
• Protein Name: Retina-specific copper amine oxidase
• Gene Name: AOC2
• Organism: Homo sapiens (Human).
• Sequence Length: 756
• Subcellular Localization: Isoform 1: Cell membrane ; Peripheral membrane protein . Present on the surface of the cells.; Isoform 2: Cytoplasm . Either not translocated to the plasma membrane or below detection level.
• Protein Description: Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina..
• Protein Sequence: MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	N-linked_Glycosylation	FGGQPQPNVSELVVG ECCCCCCCCCEEEEE	44.70	UniProtKB CARBOHYD
198	N-linked_Glycosylation	LSSTFNYNGSTLAAV EEEEECCCCCEEEEE	38.76	UniProtKB CARBOHYD
226	N-linked_Glycosylation	TWMALYHNISGVGLF HHHHHHCCCCCCCEE	19.30	UniProtKB CARBOHYD
277	Phosphorylation	QLEREFKSGRLEVVR HHHHHHHCCCEEEEE	34.17	25022875
465	Other	SVSSVGNYDYIWDFV ECCCCCCCCEEEEEE	12.28	-
465	"2',4',5'-topaquinone"	SVSSVGNYDYIWDFV ECCCCCCCCEEEEEE	12.28	-
467	Phosphorylation	SSVGNYDYIWDFVLY CCCCCCCEEEEEEEE	8.11	7456643
474	Phosphorylation	YIWDFVLYPNGALEG EEEEEEEECCCCCCC	6.86	7456653
486	Phosphorylation	LEGRVHATGYINTAF CCCCEECEEEEEEEE	18.68	70959431
488	Phosphorylation	GRVHATGYINTAFLK CCEECEEEEEEEEEC	6.14	7456663
491	Phosphorylation	HATGYINTAFLKGGE ECEEEEEEEEECCCH	14.82	70959433
577	Phosphorylation	LTAFSLGSPLPRYLY CCEECCCCCCCCEEE	28.67	24719451
587 (in isoform 2)	Phosphorylation	-	27.20	-
587	Phosphorylation	PRYLYLASNQTNAWG CCEEEECCCCCCCCC	27.20	-
588	N-linked_Glycosylation	RYLYLASNQTNAWGH CEEEECCCCCCCCCC	47.27	UniProtKB CARBOHYD
640	Phosphorylation	RKEEESQSSSIYHQN CCCHHHCCCCCCCCC	35.02	22468782
641	Phosphorylation	KEEESQSSSIYHQND CCHHHCCCCCCCCCC	17.08	22468782
653	Phosphorylation	QNDIWTPTVTFADFI CCCCCCCEEEHHHHC	25.46	22468782
662	N-linked_Glycosylation	TFADFINNETLLGED EHHHHCCCCCCCCHH	38.52	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AOC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AOC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AOC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAN1_HUMAN	LEMD3	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.