R3HCL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R3HCL_HUMAN
• UniProt AC: Q7Z5L2
• Protein Name: Coiled-coil domain-containing protein R3HCC1L
• Gene Name: R3HCC1L
• Organism: Homo sapiens (Human).
• Sequence Length: 792
• Protein Sequence: MQQESERCRVRARRPDMALYVPKARRGAVLLKTGDEEESCGSPNSVVKEKQKESSLSQKEVFKDKPEARRLNINPDRKEHNCREEKKSSTKLRMDTCLQKTNRVCSKRGTTESKEVLSQGQQQGAPNAGVITNAPLQRHFKPKKVECLEVETTDVTGHERILLSQACLEISEAQVPSKPFQNVEFCDFSRHEPDGEAFEDKDLEGRIETDTKVLEILYEFPRVFSSVMKPENMIVPIKLSSDSEIVQQSMQTSDGILNPSSGGITTTSVPGSPDGVFDQTCVDFEVESVGGIANSTGFILDQKDTDSIPATMGHISLSESTNDTVSPVMIRECEKNDSTADELHVKHEPPDTAVLAHETHRDSGFKNVGDITNKACMMDTTGMSCSDHVTVDSPYVVAVRIADETSINTRSFSKFVGMSADATPLHVARSGNDTEDFSNPSACSDIYGESISSHFTESTGKLIESLSDCASSLPIKKIAGSNYNTFLDSELSMLNGTKVLSDSAVGIDLGSTGDTTEALHELRTAEEFKTEEQDDSGSIEFGVSFPDRESSSMETSIEPKATETSHTEGITAIEESWESMFNDDGDCLDPRLLQEGILMHIKPENHCSELSGNTKSRESIQEPRSDYYNHEVPDIDLSDCEFPHVIEIYDFPQEFHTEDLLRVFCSYQKKGFDIKWVDDTHALGVFSSPITARDALGIKHTMVKIRPLSQATRAAKAKARAYAEFLQPAKERPETSAALARRLVISALGVRSKQSKTEREAELKKLQEARERKRLEAKQREDIWEGRDQSTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	RRPDMALYVPKARRG CCCCCEEECCCCCCC	12.74	22817900
32	Ubiquitination	RRGAVLLKTGDEEES CCCEEEEECCCCCCC	46.42	-
33	Phosphorylation	RGAVLLKTGDEEESC CCEEEEECCCCCCCC	50.24	23312004
39	Phosphorylation	KTGDEEESCGSPNSV ECCCCCCCCCCCCHH	27.36	22199227
42	Phosphorylation	DEEESCGSPNSVVKE CCCCCCCCCCHHHHH	25.82	21815630
45	Phosphorylation	ESCGSPNSVVKEKQK CCCCCCCHHHHHHHH	31.50	23312004
54	Phosphorylation	VKEKQKESSLSQKEV HHHHHHCCCCCCHHH	43.55	26074081
55	Phosphorylation	KEKQKESSLSQKEVF HHHHHCCCCCCHHHH	32.88	26074081
118	Phosphorylation	TESKEVLSQGQQQGA CCCHHHHHHHHCCCC	37.12	-
212	Ubiquitination	GRIETDTKVLEILYE CCEECCHHHHHHHHH	47.86	-
218	Phosphorylation	TKVLEILYEFPRVFS HHHHHHHHHCHHHHH	22.61	21945579
225	Phosphorylation	YEFPRVFSSVMKPEN HHCHHHHHCCCCCCC	21.11	23917254
226	Phosphorylation	EFPRVFSSVMKPENM HCHHHHHCCCCCCCE	18.11	-
307	Phosphorylation	LDQKDTDSIPATMGH CCCCCCCCCCCCCCE	32.34	-
338	Phosphorylation	RECEKNDSTADELHV EEHHCCCCCCCCCCC	34.58	25159151
339	Phosphorylation	ECEKNDSTADELHVK EHHCCCCCCCCCCCC	40.78	29396449
359	Phosphorylation	TAVLAHETHRDSGFK CEEEEHHHCCCCCCC	16.61	28555341
363	Phosphorylation	AHETHRDSGFKNVGD EHHHCCCCCCCCHHH	46.19	28555341
366	Ubiquitination	THRDSGFKNVGDITN HCCCCCCCCHHHHHC	55.00	-
395	Phosphorylation	HVTVDSPYVVAVRIA CCCCCCCEEEEEEEC	16.11	27642862
411	Phosphorylation	ETSINTRSFSKFVGM CCCCCCCHHHHHCCC	31.65	24719451
419	Phosphorylation	FSKFVGMSADATPLH HHHHCCCCCCCCCEE	19.64	28555341
423	Phosphorylation	VGMSADATPLHVARS CCCCCCCCCEEECCC	27.25	28555341
465	Phosphorylation	STGKLIESLSDCASS HHHHHHHHHHHHHHC	26.61	30108239
467	Phosphorylation	GKLIESLSDCASSLP HHHHHHHHHHHHCCC	39.67	30108239
471	Phosphorylation	ESLSDCASSLPIKKI HHHHHHHHCCCHHHH	38.44	30108239
472	Phosphorylation	SLSDCASSLPIKKIA HHHHHHHCCCHHHHC	21.46	30108239
477	Ubiquitination	ASSLPIKKIAGSNYN HHCCCHHHHCCCCCH	38.21	-
501	Phosphorylation	LNGTKVLSDSAVGID HCCCEEECCCCCCEE	32.29	-
503	Phosphorylation	GTKVLSDSAVGIDLG CCEEECCCCCCEECC	22.83	-
556	Phosphorylation	ESSSMETSIEPKATE CCCCCCEECCCCCCC	16.20	28985074
597 (in isoform 2)	Phosphorylation	-	2.80	25159151
619	Phosphorylation	GNTKSRESIQEPRSD CCCCCHHHHCCCHHH	28.58	24719451
627	Phosphorylation	IQEPRSDYYNHEVPD HCCCHHHCCCCCCCC	13.86	22817900
687	Phosphorylation	THALGVFSSPITARD CCCCEECCCCCCHHH	32.57	23186163
688	Phosphorylation	HALGVFSSPITARDA CCCEECCCCCCHHHH	14.62	22199227
691	Phosphorylation	GVFSSPITARDALGI EECCCCCCHHHHHCC	21.01	23186163
699	Ubiquitination	ARDALGIKHTMVKIR HHHHHCCCCEEEEEE	31.09	-
712	Phosphorylation	IRPLSQATRAAKAKA EEEHHHHHHHHHHHH	17.13	-
736	Phosphorylation	AKERPETSAALARRL HHHCHHHHHHHHHHH	15.19	-
746	Phosphorylation	LARRLVISALGVRSK HHHHHHHHHHCCCCC	15.23	-
757	Phosphorylation	VRSKQSKTEREAELK CCCCCCHHHHHHHHH	45.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R3HCL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R3HCL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R3HCL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC103_HUMAN	CCDC103	physical	25416956
PABP1_HUMAN	PABPC1	physical	20930030
MGN_HUMAN	MAGOH	physical	20930030
RBM8A_HUMAN	RBM8A	physical	20930030

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.