DPH5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPH5_HUMAN
• UniProt AC: Q9H2P9
• Protein Name: Diphthine methyl ester synthase
• Gene Name: DPH5
• Organism: Homo sapiens (Human).
• Sequence Length: 285
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis..
• Protein Sequence: MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATKLGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEIVQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLYLIGLGLG -----CEEEEECCCC	8.58	-
16	Phosphorylation	LGDAKDITVKGLEVV CCCHHHCCHHHHHHH	26.71	-
18	Ubiquitination	DAKDITVKGLEVVRR CHHHCCHHHHHHHHH	49.48	21906983
18 (in isoform 5)	Ubiquitination	-	49.48	21906983
18 (in isoform 4)	Ubiquitination	-	49.48	21906983
18 (in isoform 3)	Ubiquitination	-	49.48	21906983
18 (in isoform 2)	Ubiquitination	-	49.48	22053931
18 (in isoform 1)	Ubiquitination	-	49.48	21906983
30	Phosphorylation	VRRCSRVYLEAYTSV HHHCCHHHHHHHHHH	9.56	20068231
34	Phosphorylation	SRVYLEAYTSVLTVG CHHHHHHHHHHHHHC	7.09	20068231
35	Phosphorylation	RVYLEAYTSVLTVGK HHHHHHHHHHHHHCH	21.29	20068231
36	Phosphorylation	VYLEAYTSVLTVGKE HHHHHHHHHHHHCHH	11.49	20068231
39	Phosphorylation	EAYTSVLTVGKEALE HHHHHHHHHCHHHHH	25.67	20068231
52	Ubiquitination	LEEFYGRKLVVADRE HHHHHCCCEEEECHH	41.07	-
100	Ubiquitination	DLVLRATKLGIPYRV HHHHHHHHCCCCCEE	43.67	-
126	Ubiquitination	CCGLQLYKFGETVSI CCCEEEECCCCEEEE	56.32	-
126 (in isoform 3)	Ubiquitination	-	56.32	21906983
126 (in isoform 2)	Ubiquitination	-	56.32	22053931
171	Phosphorylation	DIKVKEQSLENLIKG EEECCHHHHHHHHCC	38.45	30266825
177 (in isoform 4)	Ubiquitination	-	56.69	21906983
177 (in isoform 1)	Ubiquitination	-	56.69	21906983
177	Ubiquitination	QSLENLIKGRKIYEP HHHHHHHCCCCCCCC	56.69	21906983
180	Ubiquitination	ENLIKGRKIYEPPRY HHHHCCCCCCCCCCC	59.31	-
180 (in isoform 3)	Ubiquitination	-	59.31	21906983
180 (in isoform 2)	Ubiquitination	-	59.31	22053931
182	Phosphorylation	LIKGRKIYEPPRYMS HHCCCCCCCCCCCCC	25.97	-
187	Phosphorylation	KIYEPPRYMSVNQAA CCCCCCCCCCHHHHH	10.26	-
189 (in isoform 5)	Ubiquitination	-	14.69	21906983
231 (in isoform 1)	Ubiquitination	-	41.11	21906983
231	Ubiquitination	RVGADDQKIAAGTLR ECCCCHHHHCHHHHH	41.11	22053931
231 (in isoform 4)	Ubiquitination	-	41.11	21906983
236	Phosphorylation	DQKIAAGTLRQMCTV HHHHCHHHHHHHEEC	17.65	20068231
243 (in isoform 5)	Ubiquitination	-	4.94	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPH5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPH5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPH5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD2AP_HUMAN	CD2AP	physical	26344197
GSH1_HUMAN	GCLC	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
PARVA_HUMAN	PARVA	physical	26344197
SPART_HUMAN	SPG20	physical	26344197
ZYX_HUMAN	ZYX	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.