SSBP4_HUMAN - dbPTM
SSBP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SSBP4_HUMAN
UniProt AC Q9BWG4
Protein Name Single-stranded DNA-binding protein 4
Gene Name SSBP4
Organism Homo sapiens (Human).
Sequence Length 385
Subcellular Localization Nucleus.
Protein Description
Protein Sequence MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPDRREACEHSGEAKAFQDYSAAAAPSPVMGSMAPGDTMAAGSMAAGFFQGPPGSQPSPHNPNAPMMGPHGQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGAMEPSPRAQGHPSMGGPMQRVTPPRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVRGPWASPSGNSIPYSSSSPGSYTGPPGGGGPPGTPIMPSPGDSTNSSENMYTIMNPIGQGAGRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDGEMAAAGTFLHPFPSESYSPGMTMSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MYAKGGKG
-------CCCCCCCC		7.1022814378
2Phosphorylation------MYAKGGKGS
------CCCCCCCCC		19.6121406692
4Ubiquitination----MYAKGGKGSAV
----CCCCCCCCCCC		51.1924816145
7Acetylation-MYAKGGKGSAVPSD
-CCCCCCCCCCCCCH		59.3626051181
7Ubiquitination-MYAKGGKGSAVPSD
-CCCCCCCCCCCCCH		59.3629967540
9PhosphorylationYAKGGKGSAVPSDSQ
CCCCCCCCCCCCHHH		29.5821406692
13PhosphorylationGKGSAVPSDSQAREK
CCCCCCCCHHHHHHH		43.2121406692
15PhosphorylationGSAVPSDSQAREKLA
CCCCCCHHHHHHHHH		30.0321406692
24PhosphorylationAREKLALYVYEYLLH
HHHHHHHHHHHHHHH		8.7227762562
26PhosphorylationEKLALYVYEYLLHIG
HHHHHHHHHHHHHHC		5.8227762562
28PhosphorylationLALYVYEYLLHIGAQ
HHHHHHHHHHHHCCH		9.2527762562
37PhosphorylationLHIGAQKSAQTFLSE
HHHCCHHHHHHHHHH		17.3322210691
43PhosphorylationKSAQTFLSEIRWEKN
HHHHHHHHHHHHHCC		27.1324719451
151Asymmetric dimethylarginineGQPFMSPRFPGGPRP
CCCCCCCCCCCCCCC		42.98-
157Asymmetric dimethylargininePRFPGGPRPTLRMPS
CCCCCCCCCCCCCCC		39.86-
161Asymmetric dimethylarginineGGPRPTLRMPSQPPA
CCCCCCCCCCCCCCC		37.13-
164PhosphorylationRPTLRMPSQPPAGLP
CCCCCCCCCCCCCCC		46.0729978859
173PhosphorylationPPAGLPGSQPLLPGA
CCCCCCCCCCCCCCC		27.0429978859
201PhosphorylationGGPMQRVTPPRGMAS
CCCCCCCCCCCCCCC		29.7528674151
319PhosphorylationEGPMAAMSAMEPHHV
CCCCHHHHHCCCCCC		21.5320068231
320PhosphorylationGPMAAMSAMEPHHVN
CCCHHHHHCCCCCCC		8.0232142685
341PhosphorylationDMDGLPKSSPGAVAG
CCCCCCCCCCCCEEC		39.5623401153
342PhosphorylationMDGLPKSSPGAVAGL
CCCCCCCCCCCEECC		33.2223927012
350PhosphorylationPGAVAGLSNAPGTPR
CCCEECCCCCCCCCC		29.9930278072
355PhosphorylationGLSNAPGTPRDDGEM
CCCCCCCCCCCCCCC		17.6823401153
367PhosphorylationGEMAAAGTFLHPFPS
CCCCCCCEECCCCCC		20.4927080861
374PhosphorylationTFLHPFPSESYSPGM
EECCCCCCCCCCCCC		39.2826074081
376PhosphorylationLHPFPSESYSPGMTM
CCCCCCCCCCCCCCC		34.9427080861
377PhosphorylationHPFPSESYSPGMTMS
CCCCCCCCCCCCCCC		18.1627080861
378PhosphorylationPFPSESYSPGMTMSV
CCCCCCCCCCCCCCC		25.0226074081
382PhosphorylationESYSPGMTMSV----
CCCCCCCCCCC----		16.5327080861
384PhosphorylationYSPGMTMSV------
CCCCCCCCC------		18.6027080861
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SSBP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SSBP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SSBP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LDB1_HUMANLDB1physical
26186194
LHX1_HUMANLHX1physical
26186194
MBNL1_HUMANMBNL1physical
26186194
ISL2_HUMANISL2physical
26186194
ISL1_HUMANISL1physical
26186194
SSBP3_HUMANSSBP3physical
26186194
LHX8_HUMANLHX8physical
26186194
LMO4_HUMANLMO4physical
26186194
SAP3_HUMANGM2Aphysical
26186194
LHX4_HUMANLHX4physical
26186194
PIN1_HUMANPIN1physical
21516116
SSBP3_HUMANSSBP3physical
28514442
LDB1_HUMANLDB1physical
28514442
LHX4_HUMANLHX4physical
28514442
ISL2_HUMANISL2physical
28514442
ISL1_HUMANISL1physical
28514442
LHX8_HUMANLHX8physical
28514442
LHX1_HUMANLHX1physical
28514442
LMO4_HUMANLMO4physical
28514442
MBNL1_HUMANMBNL1physical
28514442
SAP3_HUMANGM2Aphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SSBP4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND THR-355, ANDMASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; SER-342 ANDTHR-355, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-355, AND MASSSPECTROMETRY.

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