PKNX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKNX1_HUMAN
• UniProt AC: P55347
• Protein Name: Homeobox protein PKNOX1
• Gene Name: PKNOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Nucleus .
• Protein Sequence: MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MMATQTLSIDS ----CCCCEEEEEEC	12.28	24043423
6	Phosphorylation	--MMATQTLSIDSYQ --CCCCEEEEEECCC	20.37	24043423
8	Phosphorylation	MMATQTLSIDSYQDG CCCCEEEEEECCCCC	27.95	24043423
11	Phosphorylation	TQTLSIDSYQDGQQM CEEEEEECCCCCCEE	24.03	24043423
12	Phosphorylation	QTLSIDSYQDGQQMQ EEEEEECCCCCCEEE	13.58	24043423
22	Phosphorylation	GQQMQVVTELKTEQD CCEEEEEEEEECCCC	36.42	24043423
26	Phosphorylation	QVVTELKTEQDPNCS EEEEEEECCCCCCCC	52.05	29978859
33	Phosphorylation	TEQDPNCSEPDAEGV CCCCCCCCCCCCCCC	59.82	30266825
41	Phosphorylation	EPDAEGVSPPPVESQ CCCCCCCCCCCCCCC	42.41	30266825
47	Phosphorylation	VSPPPVESQTPMDVD CCCCCCCCCCCCCCC	39.32	30266825
49	Phosphorylation	PPPVESQTPMDVDKQ CCCCCCCCCCCCCHH	29.84	30266825
140	Ubiquitination	EKVNELCKDFCSRYI HHHHHHHHHHHHHHH	67.47	-
156	Phosphorylation	CLKTKMNSETLLSGE HHHHCCCCCCCCCCC	28.58	-
166	Phosphorylation	LLSGEPGSPYSPVQS CCCCCCCCCCCCCCH	31.23	-
239	Phosphorylation	GTIRIQNSQLQLQLN CEEEEECCEEEEEEC	18.85	-
324	Phosphorylation	ILQPMLDSSCSETPK HHHHHHCCCCCCCCC	29.32	27050516
325	Phosphorylation	LQPMLDSSCSETPKT HHHHHCCCCCCCCCC	22.71	21815630
327	Phosphorylation	PMLDSSCSETPKTKK HHHCCCCCCCCCCCC	46.59	21815630
329	Phosphorylation	LDSSCSETPKTKKKT HCCCCCCCCCCCCCC	17.50	21815630
332	Phosphorylation	SCSETPKTKKKTAQN CCCCCCCCCCCCCCC	49.66	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKNX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKNX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKNX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX3_HUMAN	RFX3	physical	20211142
ZBTB3_HUMAN	ZBTB3	physical	20211142
A4_HUMAN	APP	physical	21832049
VP37C_HUMAN	VPS37C	physical	25416956
VP33A_HUMAN	VPS33A	physical	26186194
PBX1_HUMAN	PBX1	physical	26186194
PBX2_HUMAN	PBX2	physical	26186194
PBX4_HUMAN	PBX4	physical	26186194
VPS16_HUMAN	VPS16	physical	26186194
SAR1B_HUMAN	SAR1B	physical	26186194
PBX1_HUMAN	PBX1	physical	26971355
PBX4_HUMAN	PBX4	physical	28514442
PBX1_HUMAN	PBX1	physical	28514442
PBX2_HUMAN	PBX2	physical	28514442
VPS16_HUMAN	VPS16	physical	28514442
BACH_HUMAN	ACOT7	physical	28514442
PBX1_HUMAN	PBX1	physical	10654609

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.