GRB1L_HUMAN - dbPTM
GRB1L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRB1L_HUMAN
UniProt AC Q9C091
Protein Name GREB1-like protein
Gene Name GREB1L
Organism Homo sapiens (Human).
Sequence Length 1923
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description Plays a major role in early metanephros and genital development..
Protein Sequence MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQHPFSSADVKPKVEDLDKDLVNRYTQNGSLDFSNNLTVNEMEDDEDDEEMSDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVCAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWKECRSRQSSASCHSIKPSSSVSSTVTPENGTTNGYKSGFTQTDAANGNSSHGGKGSASSSTPAHTGNYSLSPRPSYASGDQATMFISGPPKKRHRGWYPGSPLPQPGLVVPVPTVRPLSRTEPLLSAPVPQTPLTGILQPRPIPAGETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVGDIVVSPLLVNCYKIPQLENKDLEKLGLTGSQFLSVENMILLTIQYLVRLGPDQVPLREEFEQIMLKAMQEFTLRERALQIGAQCVPVSPGQLPWLARLIASVSQDLVHVVVTQNSLAEGISETLRTLSEMRHYQRLPDYVVVICASKIRGNEFCVVVLGQHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKTTSLGDDLDKLLEKMQQRRGDSVVTPFDGDLNECVSPQEAAAMIPTQNLDLDNETFHIYQPQLTVARKLLSQVCAIADSGSQSLDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLGLEENGTAHQRAEKYVVRLDNEIQTKFEVFMRRVKQNPYTLFVLVHDNSHVELTSVISGSLSHSEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSSNEVHWIQLDTGEDVGCEEKLYFGLSEYSKSLQWGITSPLLRCDETFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTTMASLRDHSTPETLSIMDDLISSPGKNKSGRGHMLIIRVPSVQLAMLAKERLQEVRDKLGLQYRFEIILGNPATELSVATHFVARLKSWRGNEPEEWIPRTYQDLDGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACCYVSKEVIRGPTVALDLSGKEQERAAVSENDSDELLIDLERPQSNSSAVTGTSGSIMENGVSSSSTADKSQKQSLTPSFQSPATSLGLDEGVSASSAGAGAGETLKQECDSLGPQMASSTTSKPSSSSSGPRTLPWPGQPIRGCRGPQAALPPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPLLNKDMSSEEQSLYYRQWTLARQHHADYSNQLDPASGTRNFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTDHNESSEVSQSEGEPWPDIESFSKMPFDVSVHDPKYSLMSLVYTEKLAGVKQEVIKESKVEEPRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFTSASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLLNLFHAMEGISHLHLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWPFIVMMDDSCVLWNIHSVQEPSSQPMEVGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTSQSLKAPFSRCHVHDFILLNTDLTQNVQYDFNRYFCEDADFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMVSESLAPILPLQYICAPDSEHTLLAAPAQFLLEKFLQHASYKLFPKAIHNFRSPVLAIDCYLNIGPEVAICYISSRPHSSNVNCEGVFFSGLLLYLCDSFVGADLKKFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
206PhosphorylationNHINLKLTTQPKKQK
CCEEEEECCCCCCHH		23.0722210691
207PhosphorylationHINLKLTTQPKKQKH
CEEEEECCCCCCHHC		54.0022210691
253PhosphorylationSCHSIKPSSSVSSTV
CCCCCCCCCCCCCEE		30.1821949786
254PhosphorylationCHSIKPSSSVSSTVT
CCCCCCCCCCCCEEC		43.2021949786
255PhosphorylationHSIKPSSSVSSTVTP
CCCCCCCCCCCEECC		30.2921949786
257PhosphorylationIKPSSSVSSTVTPEN
CCCCCCCCCEECCCC		23.4121949786
258PhosphorylationKPSSSVSSTVTPENG
CCCCCCCCEECCCCC		25.4121949786
259PhosphorylationPSSSVSSTVTPENGT
CCCCCCCEECCCCCC		22.3821949786
261PhosphorylationSSVSSTVTPENGTTN
CCCCCEECCCCCCCC		25.6021949786
266PhosphorylationTVTPENGTTNGYKSG
EECCCCCCCCCCCCC		28.7721949786
267PhosphorylationVTPENGTTNGYKSGF
ECCCCCCCCCCCCCC		28.2221949786
272PhosphorylationGTTNGYKSGFTQTDA
CCCCCCCCCCCCCCC		30.5621949786
275PhosphorylationNGYKSGFTQTDAANG
CCCCCCCCCCCCCCC		33.8021949786
277PhosphorylationYKSGFTQTDAANGNS
CCCCCCCCCCCCCCC		25.2521949786
284PhosphorylationTDAANGNSSHGGKGS
CCCCCCCCCCCCCCC		25.7221949786
285PhosphorylationDAANGNSSHGGKGSA
CCCCCCCCCCCCCCC		30.1021949786
291PhosphorylationSSHGGKGSASSSTPA
CCCCCCCCCCCCCCC		28.5925072903
293PhosphorylationHGGKGSASSSTPAHT
CCCCCCCCCCCCCCC		26.9025072903
294PhosphorylationGGKGSASSSTPAHTG
CCCCCCCCCCCCCCC		37.6425072903
295PhosphorylationGKGSASSSTPAHTGN
CCCCCCCCCCCCCCC		35.6025072903
296PhosphorylationKGSASSSTPAHTGNY
CCCCCCCCCCCCCCC		26.8325072903
300PhosphorylationSSSTPAHTGNYSLSP
CCCCCCCCCCCCCCC		29.2725072903
303PhosphorylationTPAHTGNYSLSPRPS
CCCCCCCCCCCCCCC		16.6025072903
304PhosphorylationPAHTGNYSLSPRPSY
CCCCCCCCCCCCCCC		26.7724719451
306PhosphorylationHTGNYSLSPRPSYAS
CCCCCCCCCCCCCCC		16.9627732954
310PhosphorylationYSLSPRPSYASGDQA
CCCCCCCCCCCCCCC		34.3125072903
311PhosphorylationSLSPRPSYASGDQAT
CCCCCCCCCCCCCCE		13.8925072903
313PhosphorylationSPRPSYASGDQATMF
CCCCCCCCCCCCEEE		34.3725072903
318PhosphorylationYASGDQATMFISGPP
CCCCCCCEEEEECCC		13.6425072903
322PhosphorylationDQATMFISGPPKKRH
CCCEEEEECCCCCCC		33.7025072903
336PhosphorylationHRGWYPGSPLPQPGL
CCCCCCCCCCCCCCE		20.8228348404
394PhosphorylationPENLLSNSGVRPVIL
CHHHHCCCCCCCEEE		34.9826329039
435UbiquitinationKIPQLENKDLEKLGL
ECCCCCCCCHHHCCC		55.0729967540
487PhosphorylationLKAMQEFTLRERALQ
HHHHHHHHHHHHHHH		24.9324719451
584PhosphorylationQSRALAESMLTTSEF
HHHHHHHHHCCHHHH		17.3126074081
587PhosphorylationALAESMLTTSEFLKE
HHHHHHCCHHHHHHH		21.4526074081
588PhosphorylationLAESMLTTSEFLKEI
HHHHHCCHHHHHHHH		23.4626074081
589PhosphorylationAESMLTTSEFLKEIS
HHHHCCHHHHHHHHC		22.5526074081
622UbiquitinationSLGDDLDKLLEKMQQ
CCCHHHHHHHHHHHH		63.3729967540
626UbiquitinationDLDKLLEKMQQRRGD
HHHHHHHHHHHHCCC		41.8129967540
713PhosphorylationFIIIVPRSEVLVQQT
EEEEEECHHHHHHHH		26.4522210691
720PhosphorylationSEVLVQQTLQRIRQS
HHHHHHHHHHHHHHC		14.0422210691
878PhosphorylationSLQWGITSPLLRCDE
HCCCCCCCCHHHCHH		16.1924719451
886PhosphorylationPLLRCDETFEKMVNT
CHHHCHHHHHHHHHH		24.6818452278
923PhosphorylationSEALMALTTMASLRD
HHHHHHHHHHHHHCC		12.6522210691
986PhosphorylationRDKLGLQYRFEIILG
HHHHCCEEEEEEEEC		23.4726074081
997PhosphorylationIILGNPATELSVATH
EEECCCCCHHHHHHH		38.4226074081
1061PhosphorylationCDLRLIDSSYLTRTA
CCEEEECCHHHHHHH		17.56-
1062PhosphorylationDLRLIDSSYLTRTAL
CEEEECCHHHHHHHH		22.03-
1063PhosphorylationLRLIDSSYLTRTALE
EEEECCHHHHHHHHH		18.95-
1065PhosphorylationLIDSSYLTRTALEQE
EECCHHHHHHHHHHH		20.10-
1089PhosphorylationKEVIRGPTVALDLSG
HHHHCCCEEEECCCC		22.6422210691
1095PhosphorylationPTVALDLSGKEQERA
CEEEECCCCHHHHHH		47.7021815630
1097UbiquitinationVALDLSGKEQERAAV
EEECCCCHHHHHHHC		53.5029967540
1202PhosphorylationSSTTSKPSSSSSGPR
CCCCCCCCCCCCCCC		46.73-
1266PhosphorylationHADVAWVSSLRPLLN
CCCHHHHHHHHHHHC		16.9824719451
1267PhosphorylationADVAWVSSLRPLLNK
CCHHHHHHHHHHHCC		20.8324719451
1378PhosphorylationEPWPDIESFSKMPFD
CCCCCHHHHHCCCCC		34.8424719451
1394PhosphorylationSVHDPKYSLMSLVYT
ECCCCCCCHHHHHHH		24.5825219547
1397PhosphorylationDPKYSLMSLVYTEKL
CCCCCHHHHHHHHHH		21.7025219547
1400PhosphorylationYSLMSLVYTEKLAGV
CCHHHHHHHHHHCCC		17.9325219547
1401PhosphorylationSLMSLVYTEKLAGVK
CHHHHHHHHHHCCCC		21.1125219547
1427PhosphorylationPRKRETVSIMLTKYA
CCCCCCHHHHHHHHH		15.0829396449
1431PhosphorylationETVSIMLTKYAAYNT
CCHHHHHHHHHHHHH		12.4829396449
1606UbiquitinationRLEELGIKRQCVWPF
HHHHHCCHHHCCCEE		34.3232142685
1673PhosphorylationILGIQKWSSKLTSQS
HHHHHHHHHHHCCCC		25.3222210691
1674PhosphorylationLGIQKWSSKLTSQSL
HHHHHHHHHHCCCCC		30.4822210691
1677PhosphorylationQKWSSKLTSQSLKAP
HHHHHHHCCCCCCCC		28.58-
1680PhosphorylationSSKLTSQSLKAPFSR
HHHHCCCCCCCCCCC		31.4422210691
1686PhosphorylationQSLKAPFSRCHVHDF
CCCCCCCCCCCCCEE		32.70-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRB1L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRB1L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRB1L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GRB1L_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRB1L_HUMAN

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Related Literatures of Post-Translational Modification

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