ZNFX1_HUMAN - dbPTM
ZNFX1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZNFX1_HUMAN
UniProt AC Q9P2E3
Protein Name NFX1-type zinc finger-containing protein 1
Gene Name ZNFX1
Organism Homo sapiens (Human).
Sequence Length 1918
Subcellular Localization
Protein Description
Protein Sequence MEERRPHLDARPRNSHTNHRGPVDGELPPRARNQANNPPANALRGGASHPGRHPRANNHPAAYWQREERFRAMGRNPHQGRRNQEGHASDEARDQRHDQENDTRWRNGNQDCRNRRPPWSNDNFQQWRTPHQKPTEQPQQAKKLGYKFLESLLQKDPSEVVITLATSLGLKELLSHSSMKSNFLELICQVLRKACSSKMDRQSVLHVLGILKNSKFLKVCLPAYVVGMITEPIPDIRNQYPEHISNIISLLQDLVSVFPASSVQETSMLVSLLPTSLNALRASGVDIEEETEKNLEKVQTIIEHLQEKRREGTLRVDTYTLVQPEAEDHVESYRTMPIYPTYNEVHLDERPFLRPNIISGKYDSTAIYLDTHFRLLREDFVRPLREGILELLQSFEDQGLRKRKFDDIRIYFDTRIITPMCSSSGIVYKVQFDTKPLKFVRWQNSKRLLYGSLVCMSKDNFETFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSFLMVETTAYFEAYRHVLEGLQEVQEEDVPFQRNIVECNSHVKEPRYLLMGGRYDFTPLIENPSATGEFLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGLKIVQALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMTQMKESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWESLMNGPVQDSEWICFQHWKHSMMLEWLGLGVGSFTQSVSPAGPENTAQAEGDEEEEGEEESSLIEIAEEADLIQADRVIEEEEVVRPQRRKKEESGADQELAKMLLAMRLDHCGTGTAAGQEQATGEWQTQRNQKKKMKKRVKDELRKLNTMTAAEANEIEDVWQLDLSSRWQLYRLWLQLYQADTRRKILSYERQYRTSAERMAELRLQEDLHILKDAQVVGMTTTGAAKYRQILQKVEPRIVIVEEAAEVLEAHTIATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVKVNIPFVRLNYQHRMCPEIARLLTPHIYQDLENHPSVLKYEKIKGVSSNLFFVEHNFPEQEIQEGKSHQNQHEAHFVVELCKYFLCQEYLPSQITILTTYTGQLFCLRKLMPAKTFAGVRVHVVDKYQGEENDIILLSLVRSNQEGKVGFLQISNRICVALSRAKKGMYCIGNMQMLAKVPLWSKIIHTLRENNQIGPMLRLCCQNHPETHTLVSKASDFQKVPEGGCSLPCEFRLGCGHVCTRACHPYDSSHKEFQCMKPCQKVICQEGHRCPLVCFQECQPCQVKVPKTIPRCGHEQMVPCSVPESDFCCQEPCSKSLRCGHRCSHPCGEDCVQLCSEMVTIKLKCGHSQPVKCGHVEGLLYGGLLVKCTTKCGTILDCGHPCPGSCHSCFEGRFHERCQQPCKRLLICSHKCQEPCIGECPPCQRTCQNRCVHSQCKKKCGELCSPCVEPCVWRCQHYQCTKLCSEPCNRPPCYVPCTKLLVCGHPCIGLCGEPCPKKCRICHMDEVTQIFFGFEDEPDARFVQLEDCSHIFEVQALDRYMNEQKDDEVAIRLKVCPICQVPIRKNLRYGTSIKQRLEEIEIIKEKIQGSAGEIATSQERLKALLERKSLLHQLLPEDFLMLKEKLAQKNLSVKDLGLVENYISFYDHLASLWDSLKKMHVLEEKRVRTRLEQVHEWLAKKRLSFTSQELSDLRSEIQRLTYLVNLLTRYKIAEKKVKDSIAVEVYSVQNILEKTCKFTQEDEQLVQEKMEALKATLPCSGLGISEEERVQIVSAIGYPRGHWFKCRNGHIYVIGDCGGAMERGTCPDCKEVIGGTNHTLERSNQLASEMDGAQHAAWSDTANNLMNFEEIQGMM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44MethylationNPPANALRGGASHPG
CCCCCCCCCCCCCCC		38.8012020347
63PhosphorylationANNHPAAYWQREERF
CCCCCCHHHHHHHHH		12.27-
272UbiquitinationETSMLVSLLPTSLNA
HHHHHHHHCHHCHHH		5.3122817900
293 (in isoform 1)Ubiquitination-74.4021890473
293 (in isoform 2)Ubiquitination-74.4021906983
293UbiquitinationDIEEETEKNLEKVQT
CCHHHHHHHHHHHHH		74.4022817900
297UbiquitinationETEKNLEKVQTIIEH
HHHHHHHHHHHHHHH		42.6922817900
308UbiquitinationIIEHLQEKRREGTLR
HHHHHHHHHHCCCEE		43.7433845483
318PhosphorylationEGTLRVDTYTLVQPE
CCCEEEEEEEEECCC		18.6228796482
319PhosphorylationGTLRVDTYTLVQPEA
CCEEEEEEEEECCCH		8.1328796482
320PhosphorylationTLRVDTYTLVQPEAE
CEEEEEEEEECCCHH		23.6528796482
343UbiquitinationMPIYPTYNEVHLDER
CCCCCCCCCEECCCC		47.4927667366
422PhosphorylationRIITPMCSSSGIVYK
EEECCCCCCCCEEEE		22.6823401153
423PhosphorylationIITPMCSSSGIVYKV
EECCCCCCCCEEEEE		27.8823401153
424PhosphorylationITPMCSSSGIVYKVQ
ECCCCCCCCEEEEEE		19.0823401153
428PhosphorylationCSSSGIVYKVQFDTK
CCCCCEEEEEEECCC		11.9723401153
435UbiquitinationYKVQFDTKPLKFVRW
EEEEECCCCCEEEEE		50.6429967540
438UbiquitinationQFDTKPLKFVRWQNS
EECCCCCEEEEECCC		50.7929967540
544UbiquitinationVECNSHVKEPRYLLM
EECCCCCCCCEEEEE		57.4821963094
558UbiquitinationMGGRYDFTPLIENPS
ECCCCCCCCCCCCCC		17.8121963094
558PhosphorylationMGGRYDFTPLIENPS
ECCCCCCCCCCCCCC		17.81-
593 (in isoform 2)Ubiquitination-42.8221906983
593 (in isoform 1)Ubiquitination-42.8221890473
593UbiquitinationDPGQWPSKEALKLDD
CCCCCCCHHHCCCCH		42.8221906983
597UbiquitinationWPSKEALKLDDSQME
CCCHHHCCCCHHHHH		57.8422817900
625UbiquitinationQGPPGTGKTYVGLKI
ECCCCCCHHHHHHHH		36.2029967540
646PhosphorylationNESVWQISLQKFPIL
CCCHHHHCCCCCCEE		15.0624719451
684PhosphorylationIVRVGGRSNSEILKQ
EEEECCCCHHHHHHH		48.2427174698
686PhosphorylationRVGGRSNSEILKQFT
EECCCCHHHHHHHHH		27.5327174698
690UbiquitinationRSNSEILKQFTLREL
CCHHHHHHHHHHHHH		49.3729967540
693PhosphorylationSEILKQFTLRELRNK
HHHHHHHHHHHHHCH		23.5527174698
715PhosphorylationPMHLRRAYMSIMTQM
CHHHHHHHHHHHHHH		6.9224043423
717PhosphorylationHLRRAYMSIMTQMKE
HHHHHHHHHHHHHHH		9.1324043423
720PhosphorylationRAYMSIMTQMKESEQ
HHHHHHHHHHHHHHH		24.6824043423
734UbiquitinationQELHEGAKTLECTMR
HHHHHHHHHHHHHHH		65.5829967540
748PhosphorylationRGVLREQYLQKYISP
HHHHHHHHHHHHCCH		13.3228152594
874PhosphorylationMRLDHCGTGTAAGQE
HHCCCCCCCCCCCCC		36.4328555341
889PhosphorylationQATGEWQTQRNQKKK
HHHCCHHHHHHHHHH		30.48-
929UbiquitinationVWQLDLSSRWQLYRL
HHCCCHHHHHHHHHH		44.8522817900
931UbiquitinationQLDLSSRWQLYRLWL
CCCHHHHHHHHHHHH		8.4222817900
940UbiquitinationLYRLWLQLYQADTRR
HHHHHHHHHHHHHHH		2.9922817900
947UbiquitinationLYQADTRRKILSYER
HHHHHHHHHHHHHHH		32.2421890473
948UbiquitinationYQADTRRKILSYERQ
HHHHHHHHHHHHHHH		44.71-
976UbiquitinationQEDLHILKDAQVVGM
HHHHHHHCCCEEEEE		50.8729967540
990UbiquitinationMTTTGAAKYRQILQK
EECCCHHHHHHHHHH		40.1921906983
990 (in isoform 1)Ubiquitination-40.1921890473
997UbiquitinationKYRQILQKVEPRIVI
HHHHHHHHCCCCEEE		45.1629967540
1011UbiquitinationIVEEAAEVLEAHTIA
EEHHHHHHHHHHHHH		5.1227667366
1061UbiquitinationSLFERLVKVNIPFVR
HHHHHHHHCCCCCCC		33.8727667366
1088PhosphorylationRLLTPHIYQDLENHP
HHHCHHHHHHHHHCC		7.9227642862
1104UbiquitinationVLKYEKIKGVSSNLF
HHCCEEECCCCCCEE		65.4129967540
1174UbiquitinationLRKLMPAKTFAGVRV
HHHHCCCCCCCCCEE		38.0029967540
1198PhosphorylationENDIILLSLVRSNQE
CCCEEEEEEECCCCC		22.7524719451
1225UbiquitinationCVALSRAKKGMYCIG
HHHHHHCCCCCEEEC		49.07-
1226UbiquitinationVALSRAKKGMYCIGN
HHHHHCCCCCEEECC		48.1821963094
1229PhosphorylationSRAKKGMYCIGNMQM
HHCCCCCEEECCHHH		6.92-
1276UbiquitinationETHTLVSKASDFQKV
CCCEEEECHHCCCCC		44.4221963094
1282UbiquitinationSKASDFQKVPEGGCS
ECHHCCCCCCCCCCC		60.8029967540
1411PhosphorylationIKLKCGHSQPVKCGH
EEEECCCCCCEECCE		22.82-
1424PhosphorylationGHVEGLLYGGLLVKC
CEEEEEEECCEEEEE		17.75-
1432PhosphorylationGGLLVKCTTKCGTIL
CCEEEEEECCCCCEE		24.46-
1433PhosphorylationGLLVKCTTKCGTILD
CEEEEEECCCCCEEC		33.53-
1472PhosphorylationCKRLLICSHKCQEPC
HCEEEEECCCCCCCC		20.9820068231
1597UbiquitinationDCSHIFEVQALDRYM
HCCCEEHHHHHHHHH		2.5522817900
1599UbiquitinationSHIFEVQALDRYMNE
CCEEHHHHHHHHHHC		19.3322817900
1615UbiquitinationKDDEVAIRLKVCPIC
CCCCCHHHEEECCCC		20.7921890473
1617UbiquitinationDEVAIRLKVCPICQV
CCCHHHEEECCCCCC		31.7629967540
1632PhosphorylationPIRKNLRYGTSIKQR
CCCCCCCCCCCHHHH		28.1123403867
1634PhosphorylationRKNLRYGTSIKQRLE
CCCCCCCCCHHHHHH		20.5322461510
1635PhosphorylationKNLRYGTSIKQRLEE
CCCCCCCCHHHHHHH		24.3522461510
1647UbiquitinationLEEIEIIKEKIQGSA
HHHHHHHHHHHCCCH		59.6322817900
1649UbiquitinationEIEIIKEKIQGSAGE
HHHHHHHHHCCCHHH		35.0122817900
1649 (in isoform 1)Ubiquitination-35.0121890473
1665UbiquitinationATSQERLKALLERKS
CCCHHHHHHHHHHHH		43.1221890473
1665 (in isoform 1)Ubiquitination-43.1221890473
1665AcetylationATSQERLKALLERKS
CCCHHHHHHHHHHHH		43.1226210075
1665MalonylationATSQERLKALLERKS
CCCHHHHHHHHHHHH		43.1226320211
1686UbiquitinationPEDFLMLKEKLAQKN
HHHHHHHHHHHHHCC		38.5529967540
1692UbiquitinationLKEKLAQKNLSVKDL
HHHHHHHCCCCHHHH		55.0029967540
1705PhosphorylationDLGLVENYISFYDHL
HHHHHHHHHHHHHHH		5.6223401153
1707PhosphorylationGLVENYISFYDHLAS
HHHHHHHHHHHHHHH		13.8523401153
1714PhosphorylationSFYDHLASLWDSLKK
HHHHHHHHHHHHHHH		36.0323401153
1718PhosphorylationHLASLWDSLKKMHVL
HHHHHHHHHHHHHHH		30.4223401153
1722SulfoxidationLWDSLKKMHVLEEKR
HHHHHHHHHHHHHHH		2.2430846556
1754PhosphorylationSFTSQELSDLRSEIQ
CCCHHHHHHHHHHHH		33.5726091039
1812UbiquitinationDEQLVQEKMEALKAT
HHHHHHHHHHHHHHH		25.5829967540
1819PhosphorylationKMEALKATLPCSGLG
HHHHHHHHCCCCCCC		29.6423663014
1823PhosphorylationLKATLPCSGLGISEE
HHHHCCCCCCCCCHH		34.8023663014
1828PhosphorylationPCSGLGISEEERVQI
CCCCCCCCHHHHHHH		36.8423663014
1882PhosphorylationVIGGTNHTLERSNQL
HCCCCCCHHHHHHHH		32.1727251275
1886PhosphorylationTNHTLERSNQLASEM
CCCHHHHHHHHHHHC		21.3922210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZNFX1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZNFX1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZNFX1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FYN_HUMANFYNphysical
26496610
CSDE1_HUMANCSDE1physical
26496610
RNC_HUMANDROSHAphysical
26496610
S18L2_HUMANSS18L2physical
26496610
AMZ2_HUMANAMZ2physical
26496610
MID51_HUMANMIEF1physical
26496610
IMP3_HUMANIMP3physical
26496610
DDX27_HUMANDDX27physical
26496610
DRC1_HUMANDRC1physical
26496610
LACTB_HUMANLACTBphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZNFX1_HUMAN

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Related Literatures of Post-Translational Modification

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