DRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRC1_HUMAN
• UniProt AC: Q96MC2
• Protein Name: Dynein regulatory complex protein 1
• Gene Name: DRC1
• Organism: Homo sapiens (Human).
• Sequence Length: 740
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, flagellum axoneme .
• Protein Description: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. [PubMed: 23354437]
• Protein Sequence: MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSELQVPPTQVLRVPTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	PNVDEHLSTQILAPS CCCCHHHCHHHHCCC		25693802
20	Phosphorylation	NVDEHLSTQILAPSV CCCHHHCHHHHCCCC		25693802
26	Phosphorylation	STQILAPSVHSDNSQ CHHHHCCCCCCCCHH		25693802
29	Phosphorylation	ILAPSVHSDNSQERI HHCCCCCCCCHHHHH		25693802
32	Phosphorylation	PSVHSDNSQERIQAR CCCCCCCHHHHHHHH		25693802
216	Acetylation	EQVKNVMKTFREELY HHHHHHHHHHHHHHH		20167786
227	Acetylation	EELYNIEKAFEVERQ HHHHCHHHHHHHHHH		20167786
242	Acetylation	ELLASNKKKWEQALQ HHHHCCHHHHHHHHH		20167786
258	Phosphorylation	HNAKELEYLNNRMKK CCHHHHHHHHHHHHH		-
453	Phosphorylation	ISQQPQKSATQIVEE CCCCCCHHHHHHHHH		30622161
455	Phosphorylation	QQPQKSATQIVEEML CCCCHHHHHHHHHHH		30622161
479	Phosphorylation	EAAAEPESYLDLPKQ HHHHCCHHHCCCCHH		30622161
480	Phosphorylation	AAAEPESYLDLPKQI HHHCCHHHCCCCHHH		30622161
544	Phosphorylation	IESEDDLYKLVNFFL CCCHHHHHHHHHHHH		25907765
568	Phosphorylation	SLQIKPCSQASMEKA CCCCCCCCHHHHHHH		30622161
571	Phosphorylation	IKPCSQASMEKASME CCCCCHHHHHHHHHC		30622161
601	O-linked_Glycosylation	MEGEKEESLVEGEKE CCCCHHHHHCCCCCC		29237092
601	Phosphorylation	MEGEKEESLVEGEKE CCCCHHHHHCCCCCC		30622161
613	Phosphorylation	EKEEEEETPPSPWVI CCCCCCCCCCCCCCC		30622161
616	Phosphorylation	EEEETPPSPWVIHPN CCCCCCCCCCCCCHH		30622161
739	Phosphorylation	TQVLRVPTK------ CCEEECCCC------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DRC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615294: Ciliary dyskinesia, primary, 21 (CILD21)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.