DCUP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCUP_HUMAN
• UniProt AC: P06132
• Protein Name: Uroporphyrinogen decarboxylase
• Gene Name: UROD
• Organism: Homo sapiens (Human).
• Sequence Length: 367
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III..
• Protein Sequence: MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCRSPEACCELTLQPLRRFPLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDLERLRDPEVVASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQAKRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYIRDVAKQVKARLREAGLAPVPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVGKTVTLQGNLDPCALYASEEEIGQLVKQMLDDFGPHRYIANLGHGLYPDMDPEHVGAFVDAVHKHSRLLRQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEANGLGP -------CCCCCCCC	11.22	22223895
15	Acetylation	PQGFPELKNDTFLRA CCCCHHHCCCCCHHH	51.63	19825541
15	Ubiquitination	PQGFPELKNDTFLRA CCCCHHHCCCCCHHH	51.63	24816145
30	Phosphorylation	AWGEETDYTPVWCMR HCCCCCCCCCCHHHH	21.99	-
32	Ubiquitination	GEETDYTPVWCMRQA CCCCCCCCCHHHHHC	16.04	17623298
36	Sulfoxidation	DYTPVWCMRQAGRYL CCCCCHHHHHCCCCC	1.77	30846556
57	Phosphorylation	RAAQDFFSTCRSPEA HHHHHHHHHCCCHHH	26.96	28857561
58	Phosphorylation	AAQDFFSTCRSPEAC HHHHHHHHCCCHHHH	13.54	28857561
61	Phosphorylation	DFFSTCRSPEACCEL HHHHHCCCHHHHHHC	29.28	21082442
66	Glutathionylation	CRSPEACCELTLQPL CCCHHHHHHCCCCCH	6.56	22555962
104	Ubiquitination	EVTMVPGKGPSFPEP EEEECCCCCCCCCCC	62.67	17623298
133	Phosphorylation	VVASELGYVFQAITL HHHHHHHHHHHHHHH	15.66	19835603
139	Phosphorylation	GYVFQAITLTRQRLA HHHHHHHHHHHHHHC	25.70	19835603
141	Phosphorylation	VFQAITLTRQRLAGR HHHHHHHHHHHHCCC	18.99	19835603
170	Ubiquitination	TYMVEGGGSSTMAQA EEEECCCCCHHHHHH	29.31	24816145
225	Ubiquitination	ESHAGHLGPQLFNKF HHCCCCCCHHHHHHH	11.39	21963094
242	Ubiquitination	PYIRDVAKQVKARLR HHHHHHHHHHHHHHH	56.31	33845483
258	Sulfoxidation	AGLAPVPMIIFAKDG CCCCCCCEEEEECCC	3.60	21406390
289	Ubiquitination	LDWTVAPKKARECVG CCCEECCHHHHHHCC	49.69	29967540
290	Ubiquitination	DWTVAPKKARECVGK CCEECCHHHHHHCCC	52.17	-
297	Ubiquitination	KARECVGKTVTLQGN HHHHHCCCEEEEECC	21.30	21963094
298	Phosphorylation	ARECVGKTVTLQGNL HHHHCCCEEEEECCC	16.88	25072903
300	Phosphorylation	ECVGKTVTLQGNLDP HHCCCEEEEECCCCC	20.70	25072903
311	Phosphorylation	NLDPCALYASEEEIG CCCCCHHCCCHHHHH	6.91	25072903
313	Phosphorylation	DPCALYASEEEIGQL CCCHHCCCHHHHHHH	31.80	25072903
342	Phosphorylation	ANLGHGLYPDMDPEH EECCCCCCCCCCHHH	11.20	20090780
359	Ubiquitination	AFVDAVHKHSRLLRQ HHHHHHHHHHHHHHC	36.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCUP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCUP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCUP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCUP_HUMAN	UROD	physical	9564029
VIME_HUMAN	VIM	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
HMGX4_HUMAN	HMGXB4	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
NDKA_HUMAN	NME1	physical	22939629
CHRC1_HUMAN	CHRAC1	physical	22863883
MTAP_HUMAN	MTAP	physical	22863883
FA84B_HUMAN	FAM84B	physical	25416956
POTEF_HUMAN	POTEF	physical	26186194
WIPI3_HUMAN	WDR45B	physical	26186194
MYCBP_HUMAN	MYCBP	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
POTEF_HUMAN	POTEF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 176100: Familial porphyria cutanea tarda (FPCT)
• 176100: Hepatoerythropoietic porphyria (HEP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330