UN13A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN13A_HUMAN
• UniProt AC: Q9UPW8
• Protein Name: Protein unc-13 homolog A
• Gene Name: UNC13A
• Organism: Homo sapiens (Human).
• Sequence Length: 1703
• Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol est
• Protein Description: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDEQDKPLPVPSNQCCNWNYFGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	PLRTIRQSNEEGPGE EHHHHHCCCCCCCCC	36.04	28270605
98	Phosphorylation	EGPGEWLTLDSQVIM CCCCCEEEECCEEEE	29.59	28270605
222	Phosphorylation	TTSQPNASVHQYSVR CCCCCCCEEEEEECC	27.11	-
240	Phosphorylation	LGSRESYSDSMHSYE CCCCCCCCCCCCCCC	32.27	21601212
242	Phosphorylation	SRESYSDSMHSYEEF CCCCCCCCCCCCCCC	16.68	-
245	Phosphorylation	SYSDSMHSYEEFSEP CCCCCCCCCCCCCCC	26.12	-
256	Phosphorylation	FSEPQALSPTGSSRY CCCCCCCCCCCCCCC	24.35	18510355
260	Phosphorylation	QALSPTGSSRYASSG CCCCCCCCCCCCCCC	17.70	25307156
376	Phosphorylation	PKDFKRISLPPAAPG CCCCCCCCCCCCCCC	38.57	22985185
443	Phosphorylation	EGQEGQDSMSRAKAN CCCCCCCHHHHHHHH	15.69	29978859
445	Phosphorylation	QEGQDSMSRAKANWL CCCCCHHHHHHHHHH	32.79	29978859
504	Phosphorylation	RKPIPLVSDLAMSLV CCCCCHHHHHHHHHH	34.29	27251275
694	Phosphorylation	GLQAKDKTGSSDPYV CCCCCCCCCCCCCCE	53.05	29083192
696	Phosphorylation	QAKDKTGSSDPYVTV CCCCCCCCCCCCEEE	36.48	29083192
697	Phosphorylation	AKDKTGSSDPYVTVQ CCCCCCCCCCCEEEE	43.90	29083192
700	Phosphorylation	KTGSSDPYVTVQVGK CCCCCCCCEEEEECC	17.47	18083107
702	Phosphorylation	GSSDPYVTVQVGKTK CCCCCCEEEEECCCC	10.20	29083192
708	Phosphorylation	VTVQVGKTKKRTKTI EEEEECCCCCEEEEE	35.55	29083192
734	Phosphorylation	FHFECHNSSDRIKVR CEEECCCCCCCEEEE	15.22	20873877
735	Phosphorylation	HFECHNSSDRIKVRV EEECCCCCCCEEEEE	35.90	20873877
750	Ubiquitination	WDEDDDIKSRVKQRF CCCCCCHHHHHHHHH	38.92	-
869	Phosphorylation	VDEFAMRYGVESIYQ HHHHHHHHCHHHHHH	16.67	-
879	Phosphorylation	ESIYQAMTHFACLSS HHHHHHHHHHHHHCC	19.50	28985074
885	Phosphorylation	MTHFACLSSKYMCPG HHHHHHHCCCCCCCC	25.35	28985074
888	Phosphorylation	FACLSSKYMCPGVPA HHHHCCCCCCCCHHH	13.09	-
943	Phosphorylation	LLDQLHNSLRIDLSM HHHHHHHHHCCCHHH	14.31	28857561
968	Phosphorylation	ERLQDLKSTVDLLTS HHHHHHHHHHHHHHH	40.74	30622161
969	Phosphorylation	RLQDLKSTVDLLTSI HHHHHHHHHHHHHHH	19.22	30622161
974	Phosphorylation	KSTVDLLTSITFFRM HHHHHHHHHHHHHHH	25.94	30622161
975	Phosphorylation	STVDLLTSITFFRMK HHHHHHHHHHHHHHH	21.43	30622161
977	Phosphorylation	VDLLTSITFFRMKVQ HHHHHHHHHHHHHHH	19.25	30622161
988	Phosphorylation	MKVQELQSPPRASQV HHHHHHCCCCCHHHH	49.88	25159151
993	Phosphorylation	LQSPPRASQVVKDCV HCCCCCHHHHHHHHH	25.45	25627689
1020	Phosphorylation	NNCHELYSREYQTDP CCHHHHHCCCCCCCH	31.12	24719451
1245	Phosphorylation	KDFASYCSKEKEKVP HHHHHHHCCCCCCCC	35.30	-
1483	Phosphorylation	GGVGLKKTFLEKSPD CCCCCCHHHHHHCCC	31.68	26074081
1488	Phosphorylation	KKTFLEKSPDLQSLR CHHHHHHCCCHHHHH	17.80	26074081
1493	Phosphorylation	EKSPDLQSLRYALSL HHCCCHHHHHHHHHH	23.31	26074081
1581	Acetylation	IGPQLSDKKRKFATK ECCCCCHHHCCCCCC	51.61	19829187
1582	Acetylation	GPQLSDKKRKFATKS CCCCCHHHCCCCCCC	66.85	19829197
1587	Phosphorylation	DKKRKFATKSKNNSW HHHCCCCCCCCCCCC	38.70	-
1593	Phosphorylation	ATKSKNNSWAPKYNE CCCCCCCCCCCCCCC	33.73	22985185
1673	Phosphorylation	LTVLRILSQRSNDEV HHHHHHHHHCCCHHH	22.60	24719451
1689	Phosphorylation	KEFVKLKSDTRSAEE HHHHHHHCCCCCHHC	55.43	29083192
1691	Phosphorylation	FVKLKSDTRSAEEGG HHHHHCCCCCHHCCC	33.35	29083192
1693	Phosphorylation	KLKSDTRSAEEGGAA HHHCCCCCHHCCCCC	41.97	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO44	Q9H4M3	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN13A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN13A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBSP1_MOUSE	Fbxo45	physical	19996097
UBX10_HUMAN	UBXN10	physical	26389662

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.