UniProt ID | SYT12_HUMAN | |
---|---|---|
UniProt AC | Q8IV01 | |
Protein Name | Synaptotagmin-12 | |
Gene Name | SYT12 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 421 | |
Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Single-pass membrane protein. |
|
Protein Description | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.. | |
Protein Sequence | MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLATLRRPVSMWHAVRRN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MAVDVAEYHLSVIKS CCCCCHHHEEEEECC | 9.79 | 27642862 | |
11 | Phosphorylation | DVAEYHLSVIKSPPG CCHHHEEEEECCCCC | 14.42 | 30206219 | |
65 | Ubiquitination | DYRYLQQKYGESCAE CHHHHHHHHHHHHHH | 42.11 | - | |
97 | Phosphorylation | GPPSRKGSLSIEDTF CCCCCCCCCCHHHHH | 23.21 | 28348404 | |
99 | Phosphorylation | PSRKGSLSIEDTFES CCCCCCCCHHHHHHH | 26.15 | 28348404 | |
108 | Phosphorylation | EDTFESISELGPLEL HHHHHHHHHHCHHHH | 35.73 | - | |
125 | Phosphorylation | RELDLAPYGTLRKSQ CCCCCCCCCCCCCCC | 19.69 | 27642862 | |
127 | Phosphorylation | LDLAPYGTLRKSQSA CCCCCCCCCCCCCCC | 19.97 | 28555341 | |
206 | Phosphorylation | DEQIVGISRIQRNAY HHHEECEEEEECCEE | 19.87 | - | |
213 | Phosphorylation | SRIQRNAYSIFFDEK EEEECCEEEEEECCC | 13.07 | 27642862 | |
214 | Phosphorylation | RIQRNAYSIFFDEKF EEECCEEEEEECCCC | 15.54 | 24076635 | |
233 | Ubiquitination | DPTALEEKSLRFSVF CCHHHCCCCCEEEEE | 45.47 | - | |
250 | Phosphorylation | DEDERNVSTGVVELK CCCCCCCCCCEEEEE | 24.00 | 22210691 | |
251 | Phosphorylation | EDERNVSTGVVELKL CCCCCCCCCEEEEEE | 29.70 | 22210691 | |
316 | Ubiquitination | NLIWTNDKTTADPFV CEEECCCCCCCCCCE | 50.25 | - | |
316 | Acetylation | NLIWTNDKTTADPFV CEEECCCCCCCCCCE | 50.25 | 20167786 | |
336 | Acetylation | QDGRKMSKKKTAVKR CCCCCCCCCCCCCCC | 55.58 | 20167786 | |
337 | Acetylation | DGRKMSKKKTAVKRD CCCCCCCCCCCCCCC | 48.31 | 20167786 | |
367 | Phosphorylation | AIVLQDLSLRVTVAE HHHEEECEEEEEEEE | 23.55 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYT12_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
97 | S | Phosphorylation |
| - |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYT12_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PDK2_HUMAN | PDK2 | physical | 28514442 | |
GMCL1_HUMAN | GMCL1 | physical | 28514442 | |
HD_HUMAN | HTT | physical | 28514442 | |
PDK3_HUMAN | PDK3 | physical | 28514442 | |
MADD_HUMAN | MADD | physical | 28514442 | |
CCD77_HUMAN | CCDC77 | physical | 28514442 | |
ENTP7_HUMAN | ENTPD7 | physical | 28514442 | |
NXPE3_HUMAN | NXPE3 | physical | 28514442 | |
MFAP3_HUMAN | MFAP3 | physical | 28514442 | |
ZN445_HUMAN | ZNF445 | physical | 28514442 | |
AT2A3_HUMAN | ATP2A3 | physical | 28514442 | |
B4GT5_HUMAN | B4GALT5 | physical | 28514442 | |
MAN1_HUMAN | LEMD3 | physical | 28514442 | |
OCLN_HUMAN | OCLN | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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