SYT12_HUMAN - dbPTM
SYT12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYT12_HUMAN
UniProt AC Q8IV01
Protein Name Synaptotagmin-12
Gene Name SYT12
Organism Homo sapiens (Human).
Sequence Length 421
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Single-pass membrane protein.
Protein Description May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis..
Protein Sequence MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLATLRRPVSMWHAVRRN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAVDVAEYHLSVIKS
CCCCCHHHEEEEECC
9.7927642862
11PhosphorylationDVAEYHLSVIKSPPG
CCHHHEEEEECCCCC
14.4230206219
65UbiquitinationDYRYLQQKYGESCAE
CHHHHHHHHHHHHHH
42.11-
97PhosphorylationGPPSRKGSLSIEDTF
CCCCCCCCCCHHHHH
23.2128348404
99PhosphorylationPSRKGSLSIEDTFES
CCCCCCCCHHHHHHH
26.1528348404
108PhosphorylationEDTFESISELGPLEL
HHHHHHHHHHCHHHH
35.73-
125PhosphorylationRELDLAPYGTLRKSQ
CCCCCCCCCCCCCCC
19.6927642862
127PhosphorylationLDLAPYGTLRKSQSA
CCCCCCCCCCCCCCC
19.9728555341
206PhosphorylationDEQIVGISRIQRNAY
HHHEECEEEEECCEE
19.87-
213PhosphorylationSRIQRNAYSIFFDEK
EEEECCEEEEEECCC
13.0727642862
214PhosphorylationRIQRNAYSIFFDEKF
EEECCEEEEEECCCC
15.5424076635
233UbiquitinationDPTALEEKSLRFSVF
CCHHHCCCCCEEEEE
45.47-
250PhosphorylationDEDERNVSTGVVELK
CCCCCCCCCCEEEEE
24.0022210691
251PhosphorylationEDERNVSTGVVELKL
CCCCCCCCCEEEEEE
29.7022210691
316UbiquitinationNLIWTNDKTTADPFV
CEEECCCCCCCCCCE
50.25-
316AcetylationNLIWTNDKTTADPFV
CEEECCCCCCCCCCE
50.2520167786
336AcetylationQDGRKMSKKKTAVKR
CCCCCCCCCCCCCCC
55.5820167786
337AcetylationDGRKMSKKKTAVKRD
CCCCCCCCCCCCCCC
48.3120167786
367PhosphorylationAIVLQDLSLRVTVAE
HHHEEECEEEEEEEE
23.5524719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYT12_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
97SPhosphorylation

-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYT12_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDK2_HUMANPDK2physical
28514442
GMCL1_HUMANGMCL1physical
28514442
HD_HUMANHTTphysical
28514442
PDK3_HUMANPDK3physical
28514442
MADD_HUMANMADDphysical
28514442
CCD77_HUMANCCDC77physical
28514442
ENTP7_HUMANENTPD7physical
28514442
NXPE3_HUMANNXPE3physical
28514442
MFAP3_HUMANMFAP3physical
28514442
ZN445_HUMANZNF445physical
28514442
AT2A3_HUMANATP2A3physical
28514442
B4GT5_HUMANB4GALT5physical
28514442
MAN1_HUMANLEMD3physical
28514442
OCLN_HUMANOCLNphysical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYT12_HUMAN

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Related Literatures of Post-Translational Modification

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