SYT12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT12_HUMAN
• UniProt AC: Q8IV01
• Protein Name: Synaptotagmin-12
• Gene Name: SYT12
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis..
• Protein Sequence: MAVDVAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNAQRASTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMEYDTASHTLNVAVMQGKDLLEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLATLRRPVSMWHAVRRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAVDVAEYHLSVIKS CCCCCHHHEEEEECC	9.79	27642862
11	Phosphorylation	DVAEYHLSVIKSPPG CCHHHEEEEECCCCC	14.42	30206219
65	Ubiquitination	DYRYLQQKYGESCAE CHHHHHHHHHHHHHH	42.11	-
97	Phosphorylation	GPPSRKGSLSIEDTF CCCCCCCCCCHHHHH	23.21	28348404
99	Phosphorylation	PSRKGSLSIEDTFES CCCCCCCCHHHHHHH	26.15	28348404
108	Phosphorylation	EDTFESISELGPLEL HHHHHHHHHHCHHHH	35.73	-
125	Phosphorylation	RELDLAPYGTLRKSQ CCCCCCCCCCCCCCC	19.69	27642862
127	Phosphorylation	LDLAPYGTLRKSQSA CCCCCCCCCCCCCCC	19.97	28555341
206	Phosphorylation	DEQIVGISRIQRNAY HHHEECEEEEECCEE	19.87	-
213	Phosphorylation	SRIQRNAYSIFFDEK EEEECCEEEEEECCC	13.07	27642862
214	Phosphorylation	RIQRNAYSIFFDEKF EEECCEEEEEECCCC	15.54	24076635
233	Ubiquitination	DPTALEEKSLRFSVF CCHHHCCCCCEEEEE	45.47	-
250	Phosphorylation	DEDERNVSTGVVELK CCCCCCCCCCEEEEE	24.00	22210691
251	Phosphorylation	EDERNVSTGVVELKL CCCCCCCCCEEEEEE	29.70	22210691
316	Ubiquitination	NLIWTNDKTTADPFV CEEECCCCCCCCCCE	50.25	-
316	Acetylation	NLIWTNDKTTADPFV CEEECCCCCCCCCCE	50.25	20167786
336	Acetylation	QDGRKMSKKKTAVKR CCCCCCCCCCCCCCC	55.58	20167786
337	Acetylation	DGRKMSKKKTAVKRD CCCCCCCCCCCCCCC	48.31	20167786
367	Phosphorylation	AIVLQDLSLRVTVAE HHHEEECEEEEEEEE	23.55	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
97	S	Phosphorylation	Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDK2_HUMAN	PDK2	physical	28514442
GMCL1_HUMAN	GMCL1	physical	28514442
HD_HUMAN	HTT	physical	28514442
PDK3_HUMAN	PDK3	physical	28514442
MADD_HUMAN	MADD	physical	28514442
CCD77_HUMAN	CCDC77	physical	28514442
ENTP7_HUMAN	ENTPD7	physical	28514442
NXPE3_HUMAN	NXPE3	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
ZN445_HUMAN	ZNF445	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
B4GT5_HUMAN	B4GALT5	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
OCLN_HUMAN	OCLN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.