CRLF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRLF1_HUMAN
• UniProt AC: O75462
• Protein Name: Cytokine receptor-like factor 1
• Gene Name: CRLF1
• Organism: Homo sapiens (Human).
• Sequence Length: 422
• Subcellular Localization: Secreted .
• Protein Description: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development..
• Protein Sequence: MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSSGPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGPAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	N-linked_Glycosylation	PELSRVLNASTLALA HHHHHHHCHHHHHHH	29.05	UniProtKB CARBOHYD
104	N-linked_Glycosylation	ALALANLNGSRQRSG HHHHHHCCCCCCCCC	46.32	UniProtKB CARBOHYD
140	N-linked_Glycosylation	LPPEKPVNISCWSKN CCCCCCCEEEEECCC	29.05	UniProtKB CARBOHYD
168	N-linked_Glycosylation	GETFLHTNYSLKYKL CEEEEEECEEEEEEE	17.41	UniProtKB CARBOHYD
170	Phosphorylation	TFLHTNYSLKYKLRW EEEEECEEEEEEEEE	22.06	24719451
219	Phosphorylation	EATNRLGSARSDVLT HHHHCCCCCCCCCEE	25.71	-
272	Phosphorylation	DFLFQAKYQIRYRVE HHHHEEEEEEEEEEC	16.52	18083107
281	Phosphorylation	IRYRVEDSVDWKVVD EEEEECCCCCEEEEE	14.41	30576142
292	N-linked_Glycosylation	KVVDDVSNQTSCRLA EEEECCCCCCCEEEC	49.34	UniProtKB CARBOHYD
294	Phosphorylation	VDDVSNQTSCRLAGL EECCCCCCCEEECCC	33.76	30576142
295	Phosphorylation	DDVSNQTSCRLAGLK ECCCCCCCEEECCCC	6.36	30576142
305	Phosphorylation	LAGLKPGTVYFVQVR ECCCCCCCEEEEEEE	22.14	22210691
321	Phosphorylation	NPFGIYGSKKAGIWS CCCCEECCCCCCCCC	17.63	22210691
331	O-linked_Glycosylation	AGIWSEWSHPTAAST CCCCCCCCCCCCCCC	18.61	OGP
334	O-linked_Glycosylation	WSEWSHPTAASTPRS CCCCCCCCCCCCCCC	29.45	OGP
337	O-linked_Glycosylation	WSHPTAASTPRSERP CCCCCCCCCCCCCCC	36.16	OGP
338	O-linked_Glycosylation	SHPTAASTPRSERPG CCCCCCCCCCCCCCC	20.28	OGP
368	Sumoylation	GPVRRELKQFLGWLK CHHHHHHHHHHHHHH	33.96	-
368	Sumoylation	GPVRRELKQFLGWLK CHHHHHHHHHHHHHH	33.96	-
382	N-linked_Glycosylation	KKHAYCSNLSFRLYD HHHCCCCCCHHHHHH	35.82	UniProtKB CARBOHYD
384	Phosphorylation	HAYCSNLSFRLYDQW HCCCCCCHHHHHHHH	16.75	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRLF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRLF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRLF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCF1_HUMAN	CLCF1	physical	10966616

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 272430: Cold-induced sweating syndrome 1 (CISS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.