LRC42_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC42_HUMAN
• UniProt AC: Q9Y546
• Protein Name: Leucine-rich repeat-containing protein 42
• Gene Name: LRRC42
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Protein Sequence: MSYYLSSENHLDPGPIYMRENGQLHMVNLALDGVRSSLQKPRPFRLFPKGFSVELCMNREDDTARKEKTDHFIFTYTREGNLRYSAKSLFSLVLGFISDNVDHIDSLIGFPEQIAEKLFSAAEARQKFTEPGAGLRALQKFTEAYGSLVLCSLCLRNRYLVISEKLEEIKSFRELTCLDLSCCKLGDEHELLEHLTNEALSSVTQLHLKDNCLSDAGVRKMTAPVRVMKRGLENLTLLDLSCNPEITDAGIGYLFSFRKLNCLDISGTGLKDIKTVKHKLQTHIGLVHSKVPLKEFDHSNCKTEGWADQIVLQWERVTAEAVKPRETSEPRAAAQRFYGKRSRAEAPLKCPLADTHMNSSEKLQFYKEKAPDCHGPVLKHEAISSQESKKSKKRPFEESETEQNNSSQPSKQKYVCLAVEDWDLLNSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYYLSSEN ------CCCCCCCCC	23.61	24043423
3	Phosphorylation	-----MSYYLSSENH -----CCCCCCCCCC	13.71	27642862
4	Phosphorylation	----MSYYLSSENHL ----CCCCCCCCCCC	7.87	27642862
6	Phosphorylation	--MSYYLSSENHLDP --CCCCCCCCCCCCC	21.34	27642862
7	Phosphorylation	-MSYYLSSENHLDPG -CCCCCCCCCCCCCC	39.56	27642862
17	Phosphorylation	HLDPGPIYMRENGQL CCCCCCEEECCCCEE	8.02	27642862
36	Phosphorylation	LALDGVRSSLQKPRP EHHHHHHHHCCCCCC	32.75	27251275
37	Phosphorylation	ALDGVRSSLQKPRPF HHHHHHHHCCCCCCC	25.02	27251275
40	Ubiquitination	GVRSSLQKPRPFRLF HHHHHCCCCCCCCCC	48.57	23000965
40	Acetylation	GVRSSLQKPRPFRLF HHHHHCCCCCCCCCC	48.57	25953088
52	Phosphorylation	RLFPKGFSVELCMNR CCCCCCEEEEEECCC	24.29	28348404
66	Ubiquitination	REDDTARKEKTDHFI CCCCCHHHHHCCEEE	62.18	-
68	Ubiquitination	DDTARKEKTDHFIFT CCCHHHHHCCEEEEE	63.39	-
127	Ubiquitination	SAAEARQKFTEPGAG HHHHHHHHCCCCCHH	49.01	21906983
129	Phosphorylation	AEARQKFTEPGAGLR HHHHHHCCCCCHHHH	48.59	25954137
140	Ubiquitination	AGLRALQKFTEAYGS HHHHHHHHHHHHHHH	55.92	-
145	Phosphorylation	LQKFTEAYGSLVLCS HHHHHHHHHHHHHHH	10.87	25954137
147	Phosphorylation	KFTEAYGSLVLCSLC HHHHHHHHHHHHHHH	11.57	25954137
165	Ubiquitination	RYLVISEKLEEIKSF CEEEEEHHHHHHHCH	55.17	21906983
170	Ubiquitination	SEKLEEIKSFRELTC EHHHHHHHCHHHCEE	46.98	21906983
209	Ubiquitination	SVTQLHLKDNCLSDA HCCHHHCCCCCCCCC	35.83	21963094
220	Sumoylation	LSDAGVRKMTAPVRV CCCCCCCCCCCCHHH	37.89	-
220	Ubiquitination	LSDAGVRKMTAPVRV CCCCCCCCCCCCHHH	37.89	29967540
220	Sumoylation	LSDAGVRKMTAPVRV CCCCCCCCCCCCHHH	37.89	-
256	Phosphorylation	AGIGYLFSFRKLNCL CCHHHHEEEEECCCE	22.88	24719451
259	Ubiquitination	GYLFSFRKLNCLDIS HHHEEEEECCCEECC	41.88	-
271	Ubiquitination	DISGTGLKDIKTVKH ECCCCCCCHHHHHHH	59.77	21963094
274	Ubiquitination	GTGLKDIKTVKHKLQ CCCCCHHHHHHHHHH	58.35	22817900
279	Ubiquitination	DIKTVKHKLQTHIGL HHHHHHHHHHHCCCC	36.25	29967540
290	Ubiquitination	HIGLVHSKVPLKEFD CCCCCCCCCCHHHCC	32.75	21906983
294	Ubiquitination	VHSKVPLKEFDHSNC CCCCCCHHHCCCCCC	50.71	21963094
302	Ubiquitination	EFDHSNCKTEGWADQ HCCCCCCCCCCCHHH	54.59	29967540
323	Ubiquitination	RVTAEAVKPRETSEP EEEHHHCCCCCCCCH	45.46	21906983
349	Acetylation	SRAEAPLKCPLADTH CCCCCCCCCCCCCCC	32.52	25953088
349	Methylation	SRAEAPLKCPLADTH CCCCCCCCCCCCCCC	32.52	-
349	Ubiquitination	SRAEAPLKCPLADTH CCCCCCCCCCCCCCC	32.52	21963094
355	Phosphorylation	LKCPLADTHMNSSEK CCCCCCCCCCCHHHH	19.88	22210691
359	Phosphorylation	LADTHMNSSEKLQFY CCCCCCCHHHHHHHH	32.09	22210691
360	Phosphorylation	ADTHMNSSEKLQFYK CCCCCCHHHHHHHHH	33.47	22210691
362	Ubiquitination	THMNSSEKLQFYKEK CCCCHHHHHHHHHHH	49.92	29967540
367	Ubiquitination	SEKLQFYKEKAPDCH HHHHHHHHHHCCCCC	54.77	29967540
369	Ubiquitination	KLQFYKEKAPDCHGP HHHHHHHHCCCCCCC	62.15	29967540
379	Ubiquitination	DCHGPVLKHEAISSQ CCCCCHHCHHHCCCC	39.37	29967540
379	Sumoylation	DCHGPVLKHEAISSQ CCCCCHHCHHHCCCC	39.37	-
379	Acetylation	DCHGPVLKHEAISSQ CCCCCHHCHHHCCCC	39.37	19827773
379	Sumoylation	DCHGPVLKHEAISSQ CCCCCHHCHHHCCCC	39.37	-
385	Phosphorylation	LKHEAISSQESKKSK HCHHHCCCCCHHHHC	31.67	28985074
389	Ubiquitination	AISSQESKKSKKRPF HCCCCCHHHHCCCCC	61.38	22817900
390	Ubiquitination	ISSQESKKSKKRPFE CCCCCHHHHCCCCCC	76.43	22817900
392	Ubiquitination	SQESKKSKKRPFEES CCCHHHHCCCCCCCC	62.78	22817900
393	Ubiquitination	QESKKSKKRPFEESE CCHHHHCCCCCCCCC	72.84	21906983
399	Phosphorylation	KKRPFEESETEQNNS CCCCCCCCCCCCCCC	42.49	28555341
401	Phosphorylation	RPFEESETEQNNSSQ CCCCCCCCCCCCCCC	52.75	28555341
406	Phosphorylation	SETEQNNSSQPSKQK CCCCCCCCCCCCCCC	37.59	-
407	Phosphorylation	ETEQNNSSQPSKQKY CCCCCCCCCCCCCCE	48.51	17525332
411	Ubiquitination	NNSSQPSKQKYVCLA CCCCCCCCCCEEEEE	58.45	21906983
413	Ubiquitination	SSQPSKQKYVCLAVE CCCCCCCCEEEEEEC	43.30	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC42_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC42_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC42_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SYNC_HUMAN	NARS	physical	22939629
ZC3HE_HUMAN	ZC3H14	physical	22939629
SGT1_HUMAN	SUGT1	physical	26186194
PXDC2_HUMAN	PLXDC2	physical	26186194
AMRA1_HUMAN	AMBRA1	physical	26186194
CUL3_HUMAN	CUL3	physical	28514442
PXDC2_HUMAN	PLXDC2	physical	28514442
SGT1_HUMAN	SUGT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407, AND MASSSPECTROMETRY.
PubMed: 17525332