APH1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APH1A_HUMAN
• UniProt AC: Q96BI3
• Protein Name: Gamma-secretase subunit APH-1A
• Gene Name: APH1A
• Organism: Homo sapiens (Human).
• Sequence Length: 265
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
• Protein Description: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). [PubMed: 12297508]
• Protein Sequence: MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
92	Ubiquitination	VFRFAYYKLLKKADE HHHHHHHHHHHHHHH	34.37	-
95	Ubiquitination	FAYYKLLKKADEGLA HHHHHHHHHHHHHHH	57.25	-
96	Ubiquitination	AYYKLLKKADEGLAS HHHHHHHHHHHHHHH	62.12	-
96 (in isoform 2)	Ubiquitination	-	62.12	-
110	Phosphorylation	SLSEDGRSPISIRQM HCCCCCCCCCCHHHH	31.92	24719451
113	Phosphorylation	EDGRSPISIRQMAYV CCCCCCCCHHHHHHH	18.33	29142712
182	S-palmitoylation	GVVFFDACERRRYWA HHHHHHHHHHHHHHH	4.50	19028695
238	Phosphorylation	TAGGSLRSIQRSLLC HCCCCHHHHHHHHHH	28.50	23898821
242	Phosphorylation	SLRSIQRSLLCRRQE CHHHHHHHHHHCCCC	14.87	23898821
245	S-palmitoylation	SIQRSLLCRRQEDSR HHHHHHHHCCCCCCC	4.01	19028695
256	Phosphorylation	EDSRVMVYSALRIPP CCCCEEEEEEEECCC	3.10	21945579
257	Phosphorylation	DSRVMVYSALRIPPE CCCEEEEEEEECCCC	14.93	21945579

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APH1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APH1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APH1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NICA_HUMAN	NCSTN	physical	14572442
PSN1_HUMAN	PSEN1	physical	14572442
PEN2_HUMAN	PSENEN	physical	14572442
NICA_HUMAN	NCSTN	physical	12857757
PEN2_HUMAN	PSENEN	physical	12740439
NICA_HUMAN	NCSTN	physical	12471034
PSN1_HUMAN	PSEN1	physical	12471034
PSN2_HUMAN	PSEN2	physical	12471034
PSN1_HUMAN	PSEN1	physical	12297508
PSN2_HUMAN	PSEN2	physical	12297508
NICA_HUMAN	NCSTN	physical	12297508
NICA_HUMAN	NCSTN	physical	15474363
PEN2_HUMAN	PSENEN	physical	15474363
APH1A_HUMAN	APH1A	physical	15474363
PSN1_HUMAN	PSEN1	physical	15474363
PSN2_HUMAN	PSEN2	physical	15474363
ZEP1_HUMAN	HIVEP1	physical	21988832
TLE1_HUMAN	TLE1	physical	21988832
RFOX2_HUMAN	RBFOX2	physical	21988832
ATF4_HUMAN	ATF4	physical	21988832
HES1_HUMAN	HES1	physical	21988832
TPO_HUMAN	THPO	physical	21988832
KLF11_HUMAN	KLF11	physical	21988832
BHE40_HUMAN	BHLHE40	physical	21988832
GPTC8_HUMAN	GPATCH8	physical	21988832
ERLN2_HUMAN	ERLIN2	physical	22771797
PSN2_MOUSE	Psen2	physical	19376115
PSN1_MOUSE	Psen1	physical	19376115
PEN2_HUMAN	PSENEN	physical	19376115
NICA_HUMAN	NCSTN	physical	19376115
PSN1_HUMAN	PSEN1	physical	17911105
PEN2_HUMAN	PSENEN	physical	17911105
NICA_HUMAN	NCSTN	physical	17911105
NICA_HUMAN	NCSTN	physical	18667537
PSN1_HUMAN	PSEN1	physical	18667537
PEN2_HUMAN	PSENEN	physical	18667537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.