KLF11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF11_HUMAN
• UniProt AC: O14901
• Protein Name: Krueppel-like factor 11
• Gene Name: KLF11
• Organism: Homo sapiens (Human).
• Sequence Length: 512
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor. [PubMed: 9748269]
• Protein Sequence: MHTPDFAGPDDARAVDIMDICESILERKRHDSERSTCSILEQTDMEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQAAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAESPGSPLVSMPASA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	LERKRHDSERSTCSI HHHHCCCCCCCCCHH	28.87	24702127
73	Phosphorylation	LLRIRPLTPVSDSGD EEEEEECCCCCCCCC	25.07	12006497
82	Phosphorylation	VSDSGDVTTTVHMDA CCCCCCCEEEEEECC	22.84	-
83	Phosphorylation	SDSGDVTTTVHMDAA CCCCCCEEEEEECCC	27.03	-
100	Phosphorylation	ELPKDFHSLSTLCIT CCCCCCCCCCEEEEC	24.82	20873877
102	Phosphorylation	PKDFHSLSTLCITPP CCCCCCCCEEEECCC	23.50	20873877
103	Phosphorylation	KDFHSLSTLCITPPQ CCCCCCCEEEECCCC	30.83	20873877
107	Phosphorylation	SLSTLCITPPQSPDL CCCEEEECCCCCCCC	28.11	20873877
111	Phosphorylation	LCITPPQSPDLVEPS EEECCCCCCCCCCCC	26.59	12006497
118	Phosphorylation	SPDLVEPSTRTPVSP CCCCCCCCCCCCCCC	19.60	20873877
119	Phosphorylation	PDLVEPSTRTPVSPQ CCCCCCCCCCCCCCC	49.64	20873877
121	Phosphorylation	LVEPSTRTPVSPQVT CCCCCCCCCCCCCCC	28.29	22210691
124	Phosphorylation	PSTRTPVSPQVTDSK CCCCCCCCCCCCCCC	15.72	29255136
128	Phosphorylation	TPVSPQVTDSKACTA CCCCCCCCCCCCCCH	29.34	29255136
130	Phosphorylation	VSPQVTDSKACTATD CCCCCCCCCCCCHHH	16.88	23186163
150	Phosphorylation	AVVARALSGGAERGL HHHHHHHCCCCHHCC	33.91	28102081
165	Phosphorylation	LGLEPVPSSPCRAKG CCCEECCCCCCCCCC	47.34	25850435
166	Phosphorylation	GLEPVPSSPCRAKGT CCEECCCCCCCCCCC	23.19	12006497
258	Phosphorylation	GWPGAVQTCSPKNYE CCCCCCCCCCCCCCC	14.35	25627689
260	Phosphorylation	PGAVQTCSPKNYEND CCCCCCCCCCCCCCC	42.15	25627689
403	Ubiquitination	CSFPGCRKTYFKSSH CCCCCCCHHHCCHHH	52.21	-
412	Sumoylation	YFKSSHLKAHLRTHT HCCHHHHHHHHHHCC	28.47	-
412	Sumoylation	YFKSSHLKAHLRTHT HCCHHHHHHHHHHCC	28.47	-
412	Ubiquitination	YFKSSHLKAHLRTHT HCCHHHHHHHHHHCC	28.47	-
417	Phosphorylation	HLKAHLRTHTGEKPF HHHHHHHHCCCCCCC	30.10	-
419	Phosphorylation	KAHLRTHTGEKPFNC HHHHHHCCCCCCCCC	46.56	-
447	Phosphorylation	ELSRHRRTHTGEKKF HHHHHHCCCCCCCEE	24.60	-
449	Phosphorylation	SRHRRTHTGEKKFVC HHHHCCCCCCCEEEE	46.56	-
466	Phosphorylation	CDRRFMRSDHLTKHA CCCCHHCCHHHHHHH	20.00	26074081
470	Phosphorylation	FMRSDHLTKHARRHM HHCCHHHHHHHHHHH	19.84	26074081
471	Ubiquitination	MRSDHLTKHARRHMT HCCHHHHHHHHHHHC	41.44	21906983
503	Phosphorylation	ASAESPGSPLVSMPA CCCCCCCCCCCCCCC	20.60	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLF11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	11438660
HDAC1_HUMAN	HDAC1	physical	11438660
SIN3A_HUMAN	SIN3A	physical	12006497
SIN3A_HUMAN	SIN3A	physical	22318730
EP300_HUMAN	EP300	physical	22318730
SIN3A_HUMAN	SIN3A	physical	15300592
1433Z_HUMAN	YWHAZ	physical	21988832
TIM13_HUMAN	TIMM13	physical	21988832
TXND9_HUMAN	TXNDC9	physical	25416956
APBP2_HUMAN	APPBP2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610508: Maturity-onset diabetes of the young 7 (MODY7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.