dbPTM

PSN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSN2_MOUSE
UniProt AC	Q61144
Protein Name	Presenilin-2
Gene Name	Psen2
Organism	Mus musculus (Mouse).
Sequence Length	448
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein. Golgi apparatus membrane Multi-pass membrane protein.
Protein Description	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity)..
Protein Sequence	MLAFMASDSEEEVCDERTSLMSAESPTSRSCQEGRPGPEDGESTAQWRTQESEEDCEEDPDRYACSGAPGRPSGLEEELTLKYGAKRVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEPSYPEAFEAPLPGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWNTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLAFMASDSEEEVC -CCCCCCCCCHHHHH	29.86	30635358
9	Phosphorylation	LAFMASDSEEEVCDE CCCCCCCCHHHHHHH	44.40	30635358
18	Phosphorylation	EEVCDERTSLMSAES HHHHHHHHCCCCCCC	24.94	28833060
19	Phosphorylation	EVCDERTSLMSAESP HHHHHHHCCCCCCCC	28.44	28833060
22	Phosphorylation	DERTSLMSAESPTSR HHHHCCCCCCCCCCC	33.89	22942356
25	Phosphorylation	TSLMSAESPTSRSCQ HCCCCCCCCCCCCCC	32.94	25521595
27	Phosphorylation	LMSAESPTSRSCQEG CCCCCCCCCCCCCCC	46.16	28833060
28	Phosphorylation	MSAESPTSRSCQEGR CCCCCCCCCCCCCCC	26.11	28833060
30	Phosphorylation	AESPTSRSCQEGRPG CCCCCCCCCCCCCCC	21.66	23684622
43	Phosphorylation	PGPEDGESTAQWRTQ CCCCCCCCCCHHHCC	34.27	25619855
44	Phosphorylation	GPEDGESTAQWRTQE CCCCCCCCCHHHCCC	20.68	25619855
49	Phosphorylation	ESTAQWRTQESEEDC CCCCHHHCCCCHHHH	33.46	27087446
52	Phosphorylation	AQWRTQESEEDCEED CHHHCCCCHHHHCCC	36.15	25521595
63	Phosphorylation	CEEDPDRYACSGAPG HCCCCCCCCCCCCCC	21.24	23984901
66	Phosphorylation	DPDRYACSGAPGRPS CCCCCCCCCCCCCCC	29.80	25159016
73	Phosphorylation	SGAPGRPSGLEEELT CCCCCCCCCCHHHHH	55.43	30635358
80	Phosphorylation	SGLEEELTLKYGAKR CCCHHHHHHHHCCCH	25.20	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSN2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSN2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NICA_MOUSE	Ncstn	physical	15474363
PSN1_MOUSE	Psen1	physical	15474363
PEN2_MOUSE	Psenen	physical	15474363
APH1A_MOUSE	Aph1a	physical	15474363
SORCN_MOUSE	Sri	physical	16204356
NOTC1_MOUSE	Notch1	physical	11518718
NOTC2_MOUSE	Notch2	physical	11518718
NOTC3_MOUSE	Notch3	physical	11518718
NOTC4_MOUSE	Notch4	physical	11518718

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSN2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND MASSSPECTROMETRY.	17242355 [Abstract]