TPO_HUMAN - dbPTM
TPO_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPO_HUMAN
UniProt AC P40225
Protein Name Thrombopoietin
Gene Name THPO
Organism Homo sapiens (Human).
Sequence Length 353
Subcellular Localization Secreted.
Protein Description Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets..
Protein Sequence MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MELTELLLVVM
----CHHHHHHHHHH		15.9824043423
15PhosphorylationLVVMLLLTARLTLSS
HHHHHHHHHHHHHCC		15.0924043423
22O-linked_GlycosylationTARLTLSSPAPPACD
HHHHHHCCCCCCCCC		28.358942648
34PhosphorylationACDLRVLSKLLRDSH
CCCHHHHHHHHHCHH		20.57-
58O-linked_GlycosylationPEVHPLPTPVLLPAV
CCCCCCCCCCEEEEC		33.448942648
58PhosphorylationPEVHPLPTPVLLPAV
CCCCCCCCCCEEEEC		33.44-
58O-linked_GlycosylationPEVHPLPTPVLLPAV
CCCCCCCCCCEEEEC		33.448942648
68PhosphorylationLLPAVDFSLGEWKTQ
EEEECCCCCCCHHHH		30.88-
79PhosphorylationWKTQMEETKAQDILG
HHHHHHHHHHHHHHH		20.55-
131O-linked_GlycosylationALQSLLGTQLPPQGR
HHHHHHCCCCCCCCC		27.238942648
131O-linked_GlycosylationALQSLLGTQLPPQGR
HHHHHHCCCCCCCCC		27.238942648
179O-linked_GlycosylationCVRRAPPTTAVPSRT
EEEECCCCCCCCCCC		26.748942648
179O-linked_GlycosylationCVRRAPPTTAVPSRT
EEEECCCCCCCCCCC		26.748942648
180O-linked_GlycosylationVRRAPPTTAVPSRTS
EEECCCCCCCCCCCE		31.288942648
180O-linked_GlycosylationVRRAPPTTAVPSRTS
EEECCCCCCCCCCCE		31.288942648
184O-linked_GlycosylationPPTTAVPSRTSLVLT
CCCCCCCCCCEEEEE		41.418942648
184O-linked_GlycosylationPPTTAVPSRTSLVLT
CCCCCCCCCCEEEEE		41.418942648
197N-linked_GlycosylationLTLNELPNRTSGLLE
EEHHHCCCCCCCCEE		72.929766811
197N-linked_GlycosylationLTLNELPNRTSGLLE
EEHHHCCCCCCCCEE		72.928942648
199PhosphorylationLNELPNRTSGLLETN
HHHCCCCCCCCEECC		33.5123403867
200PhosphorylationNELPNRTSGLLETNF
HHCCCCCCCCEECCE		24.9823403867
205PhosphorylationRTSGLLETNFTASAR
CCCCCEECCEEECEE		35.29-
206N-linked_GlycosylationTSGLLETNFTASART
CCCCEECCEEECEEC		23.939766811
206N-linked_GlycosylationTSGLLETNFTASART
CCCCEECCEEECEEC		23.938942648
213O-linked_GlycosylationNFTASARTTGSGLLK
CEEECEECCCCHHHH		34.918942648
213O-linked_GlycosylationNFTASARTTGSGLLK
CEEECEECCCCHHHH		34.918942648
214O-linked_GlycosylationFTASARTTGSGLLKW
EEECEECCCCHHHHC		24.64OGP
216PhosphorylationASARTTGSGLLKWQQ
ECEECCCCHHHHCCH		24.95-
234N-linked_GlycosylationAKIPGLLNQTSRSLD
HHCCHHHCHHCCCHH		48.399766811
234N-linked_GlycosylationAKIPGLLNQTSRSLD
HHCCHHHCHHCCCHH		48.398942648
255N-linked_GlycosylationNRIHELLNGTRGLFP
HHHHHHHCCCCCCCC		63.529766811
255N-linked_GlycosylationNRIHELLNGTRGLFP
HHHHHHHCCCCCCCC		63.528942648
265O-linked_GlycosylationRGLFPGPSRRTLGAP
CCCCCCCCCCCCCCC		40.078942648
265O-linked_GlycosylationRGLFPGPSRRTLGAP
CCCCCCCCCCCCCCC		40.078942648
340N-linked_GlycosylationTPTSPLLNTSYTHSQ
CCCCCCCCCCCCCCC		34.369766811
340N-linked_GlycosylationTPTSPLLNTSYTHSQ
CCCCCCCCCCCCCCC		34.369766811
348N-linked_GlycosylationTSYTHSQNLSQEG--
CCCCCCCCCCCCC--		44.68UniProtKB CARBOHYD
348N-linked_GlycosylationTSYTHSQNLSQEG--
CCCCCCCCCCCCC--		44.689766811
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPO_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPO_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPO_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TPO_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
187950Thrombocythemia 1 (THCYT1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPO_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Peptide, disulfide, and glycosylation mapping of recombinant humanthrombopoietin from ser1 to Arg246.";
Hoffman R.C., Andersen H., Walker K., Krakover J.D., Patel S.,Stamm M.R., Osborn S.G.;
Biochemistry 35:14849-14861(1996).
Cited for: DISULFIDE BONDS, AND GLYCOSYLATION AT SER-22; THR-58; THR-131;THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255AND SER-265.
O-linked Glycosylation
ReferencePubMed
"Peptide, disulfide, and glycosylation mapping of recombinant humanthrombopoietin from ser1 to Arg246.";
Hoffman R.C., Andersen H., Walker K., Krakover J.D., Patel S.,Stamm M.R., Osborn S.G.;
Biochemistry 35:14849-14861(1996).
Cited for: DISULFIDE BONDS, AND GLYCOSYLATION AT SER-22; THR-58; THR-131;THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255AND SER-265.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory