| UniProt ID | RF1M_HUMAN | |
|---|---|---|
| UniProt AC | O75570 | |
| Protein Name | Peptide chain release factor 1, mitochondrial | |
| Gene Name | MTRF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 445 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.. | |
| Protein Sequence | MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRRYCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQLIQRLLQSADEEAIAELLDEHLKSAK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | HLLSKNWSRRYCHQD HHHCCCCCHHHHCCC | 19.10 | 24719451 | |
| 77 | Ubiquitination | WKHKALQKYMENLSK HHHHHHHHHHHHHHH | 47.63 | - | |
| 120 | Phosphorylation | LAPLAAIYQEIQETE HHHHHHHHHHHHHHH | 8.72 | - | |
| 139 | Phosphorylation | ELESMCKSLNKQDEK HHHHHHHHCCHHCHH | 32.04 | - | |
| 146 | Ubiquitination | SLNKQDEKQLQELAL HCCHHCHHHHHHHHH | 65.68 | - | |
| 155 | Ubiquitination | LQELALEERQTIDQK HHHHHHHHHHHHHHH | 51.44 | - | |
| 190 | Phosphorylation | NDVILEVTAGRTTGG CCEEEEEECCCCCCH | 17.64 | - | |
| 227 | Phosphorylation | WQFELLNYTPADYGG HHEEECCCCCCCCCC | 17.67 | - | |
| 248 | Phosphorylation | RISGDGVYKHLKYEG EECCCHHHHCCEECC | 9.75 | - | |
| 253 | Phosphorylation | GVYKHLKYEGGIHRV HHHHCCEECCCCCEE | 26.60 | - | |
| 270 | Phosphorylation | IPEVGLSSRMQRIHT CCCCCCCCCCEEECC | 36.49 | 22985185 | |
| 304 | Phosphorylation | PKDLRIDTFRAKGAG HHHCCEEEEECCCCC | 16.79 | 24719451 | |
| 313 | Methylation | RAKGAGGQHVNKTDS ECCCCCCCCCCCCCC | 36.12 | - | |
| 396 | Phosphorylation | NFTQDRVSDHRIAYE CCCCCCCCCCCCEEH | 28.70 | 26074081 | |
| 402 | Phosphorylation | VSDHRIAYEVRDIKE CCCCCCEEHHHCHHH | 16.76 | 26074081 | |
| 427 | Phosphorylation | LIQRLLQSADEEAIA HHHHHHHCCCHHHHH | 37.34 | - | |
| 442 | Ubiquitination | ELLDEHLKSAK---- HHHHHHHHHCC---- | 50.72 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RF1M_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RF1M_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RF1M_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RF1M_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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