NUDT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDT3_HUMAN
• UniProt AC: O95989
• Protein Name: Diphosphoinositol polyphosphate phosphohydrolase 1
• Gene Name: NUDT3
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Cytoplasm .
• Protein Description: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate..
• Protein Sequence: MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMKLKSNQ -------CCCCCCCC	4.89	22814378
5	Ubiquitination	---MMKLKSNQTRTY ---CCCCCCCCCCCC	41.67	24816145
19	Ubiquitination	YDGDGYKKRAACLCF CCCCCHHEEEEEEEE	38.49	24816145
28	Phosphorylation	AACLCFRSESEEEVL EEEEEECCCCCCEEE	25.81	24076635
30	Phosphorylation	CLCFRSESEEEVLLV EEEECCCCCCEEEEE	52.10	20068231
38	Phosphorylation	EEEVLLVSSSRHPDR CCEEEEEECCCCCCC	23.67	20068231
39	Phosphorylation	EEVLLVSSSRHPDRW CEEEEEECCCCCCCE	24.74	20068231
40	Phosphorylation	EVLLVSSSRHPDRWI EEEEEECCCCCCCEE	27.40	20068231
74	Ubiquitination	VCEEAGVKGTLGRLV HHHHHCCCCHHHHHE	45.31	24816145
74	Acetylation	VCEEAGVKGTLGRLV HHHHHCCCCHHHHHE	45.31	26822725
94	Phosphorylation	QERKHRTYVYVLIVT CCCCCCEEEEEEEEE	6.96	28851738
96	Phosphorylation	RKHRTYVYVLIVTEV CCCCEEEEEEEEEHH	4.51	28851738
101	Phosphorylation	YVYVLIVTEVLEDWE EEEEEEEEHHHHCCH	17.24	28851738
131	Phosphorylation	DAIKVLQYHKPVQAS HHHHHHHHCCCCCHH	13.98	28152594
133	Acetylation	IKVLQYHKPVQASYF HHHHHHCCCCCHHHH	41.78	26051181
160	Phosphorylation	TPVVATTYSVSAQSS CCEEEEEEEEECCHH	11.61	-
163	Phosphorylation	VATTYSVSAQSSMSG EEEEEEEECCHHCCC	18.04	27251275
166	Phosphorylation	TYSVSAQSSMSGIR- EEEEECCHHCCCCC-	27.94	27251275
167	Phosphorylation	YSVSAQSSMSGIR-- EEEECCHHCCCCC--	12.60	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASB13_HUMAN	ASB13	physical	16169070
RAB17_HUMAN	RAB17	physical	16169070
RL8_HUMAN	RPL8	physical	16169070
RLA1_HUMAN	RPLP1	physical	16169070
TNNT3_HUMAN	TNNT3	physical	21900206
GCP4_HUMAN	TUBGCP4	physical	21900206
WDR74_HUMAN	WDR74	physical	21900206
TIP_HUMAN	ITFG1	physical	21900206
FXYD3_HUMAN	FXYD3	physical	21900206
RN126_HUMAN	RNF126	physical	21900206
OAT_HUMAN	OAT	physical	21900206
DDR1_HUMAN	DDR1	physical	21900206
EF1G_HUMAN	EEF1G	physical	21900206
PDCD5_HUMAN	PDCD5	physical	21900206
REEP5_HUMAN	REEP5	physical	21900206
VPS51_HUMAN	VPS51	physical	21900206
KPCD3_HUMAN	PRKD3	physical	21900206
RL17_HUMAN	RPL17	physical	21900206
UBR1_HUMAN	UBR1	physical	21900206
MCM5_HUMAN	MCM5	physical	21900206
AR6P1_HUMAN	ARL6IP1	physical	21900206
NUDT5_HUMAN	NUDT5	physical	21900206
NR2C1_HUMAN	NR2C1	physical	21900206
DREB_HUMAN	DBN1	physical	21900206
HES1_HUMAN	HES1	physical	21900206
APEX1_HUMAN	APEX1	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
MEX3B_HUMAN	MEX3B	physical	21900206
DNJA1_HUMAN	DNAJA1	physical	21900206
ASB13_HUMAN	ASB13	physical	21900206
MIC19_HUMAN	CHCHD3	physical	21900206
PEX5_HUMAN	PEX5	physical	21900206
RLA1_HUMAN	RPLP1	physical	21900206
HEM1_HUMAN	ALAS1	physical	21900206
XPP1_HUMAN	XPNPEP1	physical	21900206
MAF1_HUMAN	MAF1	physical	21900206
CCL11_HUMAN	CCL11	physical	21900206

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.