RAB17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB17_HUMAN
• UniProt AC: Q9H0T7
• Protein Name: Ras-related protein Rab-17
• Gene Name: RAB17
• Organism: Homo sapiens (Human).
• Sequence Length: 212
• Subcellular Localization: Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cell projection, dendrite . May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration..
• Protein Sequence: MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAQAHRTPQPRAAP -CCCCCCCCCCCCCC	19.19	25159151
27	Phosphorylation	FKLVLLGSGSVGKSS EEEEEECCCCCCCHH	28.06	25072903
29	Phosphorylation	LVLLGSGSVGKSSLA EEEECCCCCCCHHHH	29.41	25072903
105	Phosphorylation	YDITRKDSFLKAQQW EECCCHHHHHHHHHH	35.20	24719451
108	Ubiquitination	TRKDSFLKAQQWLKD CCHHHHHHHHHHHHH	41.98	-
133	Ubiquitination	LVMLVGNKTDLSQER EEEEECCCCCCCCCE	37.17	-
148	Ubiquitination	EVTFQEGKEFADSQK EEEHHHCHHHHHHHE	49.24	-
155	Ubiquitination	KEFADSQKLLFMETS HHHHHHHEEEEEHHH	51.62	-
184	Phosphorylation	AQELLQRSDEEGQAL HHHHHHCCCHHCCCC	36.09	30576142
201	Ubiquitination	DAAVALNKGPARQAK HHCCCCCCCHHHCCC	68.10	-
209	Geranylgeranylation	GPARQAKCCAH---- CHHHCCCCCCC----	2.51	-
210	Geranylgeranylation	PARQAKCCAH----- HHHCCCCCCC-----	3.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHMP6_HUMAN	CHMP6	physical	17353931
CK049_HUMAN	C11orf49	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
RAE2_HUMAN	CHML	physical	26186194
RAE1_HUMAN	CHM	physical	26186194
MOCS1_HUMAN	MOCS1	physical	26186194
GEMI6_HUMAN	GEMIN6	physical	26186194
GTPB1_HUMAN	GTPBP1	physical	26186194
PGTB2_HUMAN	RABGGTB	physical	26186194
RAE1_HUMAN	CHM	physical	28514442
RAE2_HUMAN	CHML	physical	28514442
MOCS1_HUMAN	MOCS1	physical	28514442
BOLA1_HUMAN	BOLA1	physical	28514442
GTPB1_HUMAN	GTPBP1	physical	28514442
GEMI6_HUMAN	GEMIN6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.