CHMP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHMP6_HUMAN
• UniProt AC: Q96FZ7
• Protein Name: Charged multivesicular body protein 6
• Gene Name: CHMP6
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane . Membrane ; Lipid-anchor . Localizes to endosomal membranes.
• Protein Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes..
• Protein Sequence: MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPEKIPENVPVKARPRQAELVAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNLFGRKK ------CCCCCCCCC	39.28	15511219
18	Ubiquitination	SRVTEQDKAILQLKQ CCCCHHHHHHHHHHH	36.70	23000965
24	Ubiquitination	DKAILQLKQQRDKLR HHHHHHHHHHHHHHH	31.27	23000965
24	Malonylation	DKAILQLKQQRDKLR HHHHHHHHHHHHHHH	31.27	26320211
82	Phosphorylation	DRTENQISSLEAMVQ HCCHHHHHHHHHHHH	21.07	19053533
83	Phosphorylation	RTENQISSLEAMVQS CCHHHHHHHHHHHHH	31.68	19053533
101	Sulfoxidation	TQIEMKVMEGLQFGN HHHHHHHHHHHHHHH	2.56	21406390
119	Phosphorylation	NKMHQVMSIEEVERI HHHHHCCCHHHHHHH	28.17	28450419
130	Phosphorylation	VERILDETQEAVEYQ HHHHHHHHHHHHHHH	31.23	21815630
136	Phosphorylation	ETQEAVEYQRQIDEL HHHHHHHHHHHHHHH	11.46	29978859
189	Ubiquitination	IPENVPVKARPRQAE CCCCCCCCCCCCHHH	32.38	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHMP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHMP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHMP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NXN_HUMAN	NXN	physical	17353931
VPS25_HUMAN	VPS25	physical	16371348
VPS25_HUMAN	VPS25	physical	16973552
VPS25_HUMAN	VPS25	physical	14505570
CHM4B_HUMAN	CHMP4B	physical	14505570
CHM4B_HUMAN	CHMP4B	physical	16730941
VPS25_HUMAN	VPS25	physical	16730941
METL9_HUMAN	METTL9	physical	16730941
ELOF1_HUMAN	ELOF1	physical	16730941
CHM4B_HUMAN	CHMP4B	physical	15511219
VPS25_HUMAN	VPS25	physical	15511219

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.