dbPTM

ELOF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ELOF1_HUMAN
UniProt AC	P60002
Protein Name	Transcription elongation factor 1 homolog
Gene Name	ELOF1
Organism	Homo sapiens (Human).
Sequence Length	83
Subcellular Localization	Nucleus.
Protein Description	Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions..
Protein Sequence	MGRRKSKRKPPPKKKMTGTLETQFTCPFCNHEKSCDVKMDRARNTGVISCTVCLEEFQTPITYLSEPVDVYSDWIDACEAANQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	RKPPPKKKMTGTLET CCCCCCCCCCCCEEE	48.06	-
17	Phosphorylation	PPPKKKMTGTLETQF CCCCCCCCCCEEEEE	35.57	21712546
19	Phosphorylation	PKKKMTGTLETQFTC CCCCCCCCEEEEEEC	16.56	29214152
22	Phosphorylation	KMTGTLETQFTCPFC CCCCCEEEEEECCCC	31.90	29214152
33	Acetylation	CPFCNHEKSCDVKMD CCCCCCCCCCCEEEH	49.16	26051181
34	Phosphorylation	PFCNHEKSCDVKMDR CCCCCCCCCCEEEHH	16.74	30576142
38	Ubiquitination	HEKSCDVKMDRARNT CCCCCCEEEHHHHHC	23.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ELOF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ELOF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ELOF1_HUMAN

Related Literatures of Post-Translational Modification