| UniProt ID | DPH7_HUMAN | |
|---|---|---|
| UniProt AC | Q9BTV6 | |
| Protein Name | Diphthine methyltransferase | |
| Gene Name | DPH7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 452 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).. | |
| Protein Sequence | MMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGMEVKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNETRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWSWLLFRSLQRAPSWSFPSNLGTKTADLKGASELPTPCHECREDNDGEGHARPQSGMKPLTEGMRKNGTWLQATAATTRDCGVNPEEADSAFSLLATCSFYDHALHLWEWEGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | Ubiquitination | GPQNKGGMEVKEPQV CCCCCCCCCCCCCCE | 21890473 | ||
| 57 | Ubiquitination | NKGGMEVKEPQVRLG CCCCCCCCCCCEEEE | - | ||
| 60 | Ubiquitination | GMEVKEPQVRLGRLF CCCCCCCCEEEEEEE | 27667366 | ||
| 75 | Ubiquitination | LYSFNDNNSIHPLVE EEEECCCCCEECEEE | 22817900 | ||
| 86 | Ubiquitination | PLVEVQRKDTSAILD CEEEEECCCCCEEEC | - | ||
| 96 | Ubiquitination | SAILDMKWCHIPVAG CEEECCCEECCCCCH | 21890473 | ||
| 97 | Ubiquitination | AILDMKWCHIPVAGH EEECCCEECCCCCHH | 22817900 | ||
| 102 | Ubiquitination | KWCHIPVAGHALLGL CEECCCCCHHHHHHH | 27667366 | ||
| 139 | Ubiquitination | PLSSLALEEQCLALS HHHHHHHHHHHHHHC | 22817900 | ||
| 155 | Phosphorylation | DWSTGKTGRAGDQPL CCCCCCCCCCCCCCE | 32142685 | ||
| 165 | Ubiquitination | GDQPLKIISSDSTGQ CCCCEEEEEECCCCC | 21963094 | ||
| 170 | Ubiquitination | KIISSDSTGQLHLLM EEEEECCCCCEEEEE | 22817900 | ||
| 177 | Phosphorylation | TGQLHLLMVNETRPR CCCEEEEEEECCCHH | 32142685 | ||
| 187 | Ubiquitination | ETRPRLQKVASWQAH CCCHHHHHHHHHHHH | 21963094 | ||
| 190 | Ubiquitination | PRLQKVASWQAHQFE HHHHHHHHHHHHHHH | 21890473 | ||
| 192 | Ubiquitination | LQKVASWQAHQFEAW HHHHHHHHHHHHHHH | 22817900 | ||
| 196 | Ubiquitination | ASWQAHQFEAWIAAF HHHHHHHHHHHHHHH | 27667366 | ||
| 219 | Phosphorylation | YSGGDDGLLRGWDTR EECCCCCCCCCCCCC | 32142685 | ||
| 229 | Ubiquitination | GWDTRVPGKFLFTSK CCCCCCCCEEEEECC | 21963094 | ||
| 230 | Ubiquitination | WDTRVPGKFLFTSKR CCCCCCCEEEEECCC | 21906983 | ||
| 233 | Ubiquitination | RVPGKFLFTSKRHTM CCCCEEEEECCCCEE | 22817900 | ||
| 234 | Ubiquitination | VPGKFLFTSKRHTMG CCCEEEEECCCCEEE | 22817900 | ||
| 236 | Ubiquitination | GKFLFTSKRHTMGVC CEEEEECCCCEEEEE | 27667366 | ||
| 251 | Ubiquitination | SIQSSPHREHILATG ECCCCCCCCCEECCC | 22817900 | ||
| 269 | Phosphorylation | EHILLWDTRNMKQPL CEEEEEECCCCCCCC | 20068231 | ||
| 273 | Ubiquitination | LWDTRNMKQPLADTP EEECCCCCCCCCCCC | 21906983 | ||
| 314 | Ubiquitination | FKILNCQKAMEERQE CEECCHHHHHHHHHH | - | ||
| 323 | Ubiquitination | MEERQEATVLTSHTL HHHHHHCEEEECCCC | 21963094 | ||
| 328 | Ubiquitination | EATVLTSHTLPDSLV HCEEEECCCCCCCCC | 22817900 | ||
| 331 | Phosphorylation | VLTSHTLPDSLVYGA EEECCCCCCCCCCCC | 32142685 | ||
| 341 | Ubiquitination | LVYGADWSWLLFRSL CCCCCCHHHHHHHHH | 21963094 | ||
| 341 | Phosphorylation | LVYGADWSWLLFRSL CCCCCCHHHHHHHHH | - | ||
| 346 | Ubiquitination | DWSWLLFRSLQRAPS CHHHHHHHHHHCCCC | 22817900 | ||
| 347 | Phosphorylation | WSWLLFRSLQRAPSW HHHHHHHHHHCCCCC | - | ||
| 353 | Phosphorylation | RSLQRAPSWSFPSNL HHHHCCCCCCCCCCC | 21130716 | ||
| 355 | Phosphorylation | LQRAPSWSFPSNLGT HHCCCCCCCCCCCCC | 28464451 | ||
| 358 | Phosphorylation | APSWSFPSNLGTKTA CCCCCCCCCCCCCCC | 29978859 | ||
| 362 | Phosphorylation | SFPSNLGTKTADLKG CCCCCCCCCCCCCCC | 26074081 | ||
| 363 | Ubiquitination | FPSNLGTKTADLKGA CCCCCCCCCCCCCCC | 21963094 | ||
| 368 | Ubiquitination | GTKTADLKGASELPT CCCCCCCCCCCCCCC | 22817900 | ||
| 405 | Ubiquitination | PLTEGMRKNGTWLQA CCCCHHHHCCCEEEE | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPH7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPH7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPH7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RGPA2_HUMAN | RALGAPA2 | physical | 28514442 | |
| ZN446_HUMAN | ZNF446 | physical | 28514442 | |
| RLGPB_HUMAN | RALGAPB | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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