TR19L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR19L_HUMAN
• UniProt AC: Q969Z4
• Protein Name: Tumor necrosis factor receptor superfamily member 19L
• Gene Name: RELT
• Organism: Homo sapiens (Human).
• Sequence Length: 430
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cytoplasm .
• Protein Description: Mediates activation of NF-kappa-B. May play a role in T-cell activation..
• Protein Sequence: MKPSLLCRPLSCFLMLLPWPLATLTSTTLWQCPPGEEPDLDPGQGTLCRPCPPGTFSAAWGSSPCQPHARCSLWRRLEAQVGMATRDTLCGDCWPGWFGPWGVPRVPCQPCSWAPLGTHGCDEWGRRARRGVEVAAGASSGGETRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAHKEVGPGPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVSKLPPAPPNVPHICPHRHHLHTVQGLASLSGPCCSRCSQKKWPEVLLSPEAVAATTPVPSLLPNPTRVPKAGAKAGRQGEITILSVGRFRVARIPEQRTSSMVSEVKTITEAGPSWGDLPDSPQPGLPPEQQALLGSGGSRTKWLKPPAENKAEENRYVVRLSESNLVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	CQPHARCSLWRRLEA CCCCHHHHHHHHHHH	25.97	24719451
140	Phosphorylation	EVAAGASSGGETRQP EEEECCCCCCCCCCC	50.73	18491316
149	N-linked_Glycosylation	GETRQPGNGTRAGGP CCCCCCCCCCCCCCH	56.18	UniProtKB CARBOHYD
208	Phosphorylation	PGPGGGGSGINPAYR CCCCCCCCCCCHHHC	39.51	24961811
214	Phosphorylation	GSGINPAYRTEDANE CCCCCHHHCCCCCCC	21.23	25884760
223	Phosphorylation	TEDANEDTIGVLVRL CCCCCCCHHHHHHHH	17.29	23401153
235	Ubiquitination	VRLITEKKENAAALE HHHHHHHHHHHHHHH	50.39	-
246	Ubiquitination	AALEELLKEYHSKQL HHHHHHHHHHHHHHH	69.70	-
251	Ubiquitination	LLKEYHSKQLVQTSH HHHHHHHHHHHHCCC	34.05	-
299	Phosphorylation	GPCCSRCSQKKWPEV CCCCCCCCCCCCCCC	43.88	-
309	Phosphorylation	KWPEVLLSPEAVAAT CCCCCCCCHHHHHCC	19.28	25850435
316	Phosphorylation	SPEAVAATTPVPSLL CHHHHHCCCCCCCCC	23.15	25850435
317	Phosphorylation	PEAVAATTPVPSLLP HHHHHCCCCCCCCCC	19.98	25850435
321	Phosphorylation	AATTPVPSLLPNPTR HCCCCCCCCCCCCCC	42.65	-
327	Phosphorylation	PSLLPNPTRVPKAGA CCCCCCCCCCCCCCC	51.44	-
343	Phosphorylation	AGRQGEITILSVGRF CCCCCEEEEEEECCE	16.15	29391485
346	Phosphorylation	QGEITILSVGRFRVA CCEEEEEEECCEEEE	20.76	29391485
404	Ubiquitination	GSGGSRTKWLKPPAE CCCCCCCCCCCCCCC	49.79	-
424	Phosphorylation	NRYVVRLSESNLVI- CCEEEEECCCCCCC-	28.54	28111955
426	Phosphorylation	YVVRLSESNLVI--- EEEEECCCCCCC---	31.89	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR19L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR19L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR19L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK39_HUMAN	STK39	physical	26186194
OXSR1_HUMAN	OXSR1	physical	26186194
P55G_HUMAN	PIK3R3	physical	26186194
RFIP1_HUMAN	RAB11FIP1	physical	26186194
BACH_HUMAN	ACOT7	physical	26186194
STK39_HUMAN	STK39	physical	28514442
OXSR1_HUMAN	OXSR1	physical	28514442
RFIP1_HUMAN	RAB11FIP1	physical	28514442
BACH_HUMAN	ACOT7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.