SMG5_HUMAN - dbPTM
SMG5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMG5_HUMAN
UniProt AC Q9UPR3
Protein Name Protein SMG5
Gene Name SMG5
Organism Homo sapiens (Human).
Sequence Length 1016
Subcellular Localization Cytoplasm . Nucleus . Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Protein Description Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity..
Protein Sequence MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSQGPPTGE
------CCCCCCCCC		55.9719413330
2Phosphorylation------MSQGPPTGE
------CCCCCCCCC		55.9729255136
7Phosphorylation-MSQGPPTGESSEPE
-CCCCCCCCCCCCCC		57.6322199227
10PhosphorylationQGPPTGESSEPEAKV
CCCCCCCCCCCCHHH		41.1522199227
11PhosphorylationGPPTGESSEPEAKVL
CCCCCCCCCCCHHHH		53.5222199227
49UbiquitinationTAYQEVFKPENISLR
CCHHHHHCHHCCCHH		57.5129967540
263PhosphorylationYDKAAKMYHQLKKCE
HHHHHHHHHHHHHCC		5.9128102081
267AcetylationAKMYHQLKKCETRKL
HHHHHHHHHCCCCCC		49.1320167786
273AcetylationLKKCETRKLSPGKKR
HHHCCCCCCCCCCHH		61.8220167786
275PhosphorylationKCETRKLSPGKKRCK
HCCCCCCCCCCHHHH		34.3424719451
368PhosphorylationICLMCVHSLERAGSK
HHHHHHHHHHHCCCH		16.1324719451
415PhosphorylationNPVPAFQSDGTDEPE
CCCCCCCCCCCCCCC		31.3927732954
418PhosphorylationPAFQSDGTDEPESKE
CCCCCCCCCCCCCCC		42.0327732954
423PhosphorylationDGTDEPESKEPVEKE
CCCCCCCCCCCCCCC		53.7027732954
441PhosphorylationDPEPPPVTPQVGEGR
CCCCCCCCCCCCCCC		17.4921815630
454PhosphorylationGRKSRKFSRLSCLRR
CCCCCCCCHHHHHHH		35.0326434776
457PhosphorylationSRKFSRLSCLRRRRH
CCCCCHHHHHHHCCC		15.2526434776
472PhosphorylationPPKVGDDSDLSEGFE
CCCCCCCCCCCCCCC		45.2327251275
475PhosphorylationVGDDSDLSEGFESDS
CCCCCCCCCCCCCCC		40.4427251275
480PhosphorylationDLSEGFESDSSHDSA
CCCCCCCCCCCCCCC		40.3023312004
482PhosphorylationSEGFESDSSHDSARA
CCCCCCCCCCCCCCC		38.5623312004
483PhosphorylationEGFESDSSHDSARAS
CCCCCCCCCCCCCCC		35.9825072903
486PhosphorylationESDSSHDSARASEGS
CCCCCCCCCCCCCCC		17.7723312004
490PhosphorylationSHDSARASEGSDSGS
CCCCCCCCCCCCCCC		36.62-
493PhosphorylationSARASEGSDSGSDKS
CCCCCCCCCCCCCCC		25.26-
495PhosphorylationRASEGSDSGSDKSLE
CCCCCCCCCCCCCCC		41.72-
497PhosphorylationSEGSDSGSDKSLEGG
CCCCCCCCCCCCCCC		45.90-
523PhosphorylationMNSQESRSDLEDMEE
CCCHHCHHHHHHHHH		56.6925850435
534PhosphorylationDMEEEEGTRSPTLEP
HHHHHCCCCCCCCCC		31.1122210691
536PhosphorylationEEEEGTRSPTLEPPR
HHHCCCCCCCCCCCC		23.2926657352
538PhosphorylationEEGTRSPTLEPPRGR
HCCCCCCCCCCCCCC		45.0330266825
546PhosphorylationLEPPRGRSEAPDSLN
CCCCCCCCCCCCCCC		40.7222210691
551PhosphorylationGRSEAPDSLNGPLGP
CCCCCCCCCCCCCCH		23.7522210691
559PhosphorylationLNGPLGPSEASIASN
CCCCCCHHHHHHHHH		43.9522210691
562PhosphorylationPLGPSEASIASNLQA
CCCHHHHHHHHHHHH		18.0322210691
565PhosphorylationPSEASIASNLQAMST
HHHHHHHHHHHHHHH		36.0822210691
572PhosphorylationSNLQAMSTQMFQTKR
HHHHHHHHHHHHHCH		15.8022210691
587UbiquitinationCFRLAPTFSNLLLQP
HHHHCCCHHHHCCCC		4.4221963094
636UbiquitinationSESSGRSCRNERSIQ
CCCCCCCCCCHHHHH		5.3621963094
782UbiquitinationFIARLQGSILQFNPE
HHHHHCCCHHHCCCC		13.7321963094
795UbiquitinationPEVGIFVSIAQSEQE
CCCCEEEEECHHHHH		11.0621963094
802UbiquitinationSIAQSEQESLLQQAQ
EECHHHHHHHHHHHH		39.0221963094
838PhosphorylationLRLQLEVSQLEGSLQ
HHHHHHHHHHHHHCC		21.4821712546
843PhosphorylationEVSQLEGSLQQPKAQ
HHHHHHHHCCCCCHH		17.4028857561
848UbiquitinationEGSLQQPKAQSAMSP
HHHCCCCCHHHCCCC		55.5121963094
862UbiquitinationPYLVPDTQALCHHLP
CCCCCCHHHHHHCHH		39.4529967540
875UbiquitinationLPVIRQLATSGRFIV
HHHHHHHHHCCCEEE		7.4429967540
882UbiquitinationATSGRFIVIIPRTVI
HHCCCEEEEEECHHH		2.7429967540
908PhosphorylationGARDGIRYLEAEFKK
CCCCHHHHHHHHHHC		13.6322210691
928UbiquitinationRCQKEVGKSFERHKL
EECHHHHHHHHHHCC		58.0929967540
929PhosphorylationCQKEVGKSFERHKLK
ECHHHHHHHHHHCCH		26.81-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseSTUB1Q9UNE7
PMID:16809764
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SMG5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMG5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HDAC8_HUMANHDAC8physical
16809764
CHIP_HUMANSTUB1physical
16809764
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SMG5_HUMAN

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Related Literatures of Post-Translational Modification

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