USPL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USPL1_HUMAN
• UniProt AC: Q5W0Q7
• Protein Name: SUMO-specific isopeptidase USPL1
• Gene Name: USPL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1092
• Subcellular Localization: Nucleus, Cajal body .
• Protein Description: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. [PubMed: 22878415 Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies]
• Protein Sequence: MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKTYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEIFAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPCSERHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAASAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQLNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVNTNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAAHPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEKKKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGVSLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	GKNFDSAKVPSDEYC CCCCCCCCCCCCCCC	59.64	-
85	Phosphorylation	IYPLGSKSLNNLISP EEECCCHHHHCCCCC	37.72	29083192
91	Phosphorylation	KSLNNLISPDLEECH HHHHCCCCCCHHHCC	18.61	28985074
99	Phosphorylation	PDLEECHTPHKPQKR CCHHHCCCCCCCHHC	38.45	23898821
108	Phosphorylation	HKPQKRKSLESSYKD CCCHHCCCHHHHHHH	41.21	28985074
114	Ubiquitination	KSLESSYKDSLLLAN CCHHHHHHHHEEECC	42.67	-
116	Phosphorylation	LESSYKDSLLLANSK HHHHHHHHEEECCCC	19.43	29214152
135	Acetylation	YIAIDGGKVLNSKHN EEEECCCCEECCCCC	49.42	23236377
184	Phosphorylation	ADTVDMATTKDPATV ECEEEECCCCCCCEE	27.95	-
185	Phosphorylation	DTVDMATTKDPATVD CEEEECCCCCCCEEE	24.74	-
190	Phosphorylation	ATTKDPATVDVSGTG CCCCCCCEEECCCCC	23.72	23312004
194	Phosphorylation	DPATVDVSGTGRPSP CCCEEECCCCCCCCC	26.61	23312004
196	Phosphorylation	ATVDVSGTGRPSPQN CEEECCCCCCCCCCC	23.63	25850435
200	Phosphorylation	VSGTGRPSPQNEGCT CCCCCCCCCCCCCCC	37.44	25849741
207	Phosphorylation	SPQNEGCTSKLEMPL CCCCCCCCCCCCCCC	39.49	23663014
208	Phosphorylation	PQNEGCTSKLEMPLE CCCCCCCCCCCCCCC	39.04	23663014
415	Phosphorylation	KMVLEKVSPIFMLHF HHHHHHHCHHHHHHE	24.28	-
479	Phosphorylation	DDLKGPCSERHKKFE CCCCCCCCHHHHCCC	40.58	-
559	Phosphorylation	DISVAPRTLSQDTAV CCEECCCCCCCCCCC	29.69	29978859
561	Phosphorylation	SVAPRTLSQDTAVTH EECCCCCCCCCCCCC	25.95	29978859
564	Phosphorylation	PRTLSQDTAVTHGDH CCCCCCCCCCCCCHH	18.52	29978859
567	Phosphorylation	LSQDTAVTHGDHLLS CCCCCCCCCCHHHCC	20.06	23186163
574	Phosphorylation	THGDHLLSGPKGLVD CCCHHHCCCCCCHHH	60.45	23186163
597	Phosphorylation	ETIQKTASVSQLNSE HHHHHHCCHHHHHHH	27.77	-
720	Phosphorylation	LKPERVTSQVSNLKK CCHHHHHHHHHHCCC	26.23	28555341
731	Phosphorylation	NLKKKETTADSQTTT HCCCCCCCCCCCCCC	29.56	24719451
737	Phosphorylation	TTADSQTTTSKSLQN CCCCCCCCCCHHHHC	22.80	-
738	Phosphorylation	TADSQTTTSKSLQNQ CCCCCCCCCHHHHCH	37.23	24719451
739	Phosphorylation	ADSQTTTSKSLQNQS CCCCCCCCHHHHCHH	20.39	29759185
741	Phosphorylation	SQTTTSKSLQNQSLK CCCCCCHHHHCHHHH	34.65	24719451
908	Phosphorylation	KKLAALMSSPQSRTV HHHHHHHCCCCCCCC	39.45	27050516
909	Phosphorylation	KLAALMSSPQSRTVR HHHHHHCCCCCCCCC	17.00	30631047
912	Phosphorylation	ALMSSPQSRTVRSEN HHHCCCCCCCCCCCC	33.05	27732954
995	Phosphorylation	NGEGDFRYLGMGDSH CCCCCEEECCCCCCC	13.96	30257219
1009	Phosphorylation	HIPPPVPSEFNDVSQ CCCCCCCCCCCCCCC	55.87	30257219
1026	Phosphorylation	HLRQDHNYCSPTKKN CCCCCCCCCCCCCCC	7.29	23312004
1028	Phosphorylation	RQDHNYCSPTKKNPC CCCCCCCCCCCCCCC	25.83	28985074
1030	Phosphorylation	DHNYCSPTKKNPCEV CCCCCCCCCCCCCCC	38.05	23312004
1041	Phosphorylation	PCEVQPDSLTNNACV CCCCCCCCCCCCCEE	43.72	23312004
1043	Phosphorylation	EVQPDSLTNNACVRT CCCCCCCCCCCEEEE	30.31	23312004
1055	Phosphorylation	VRTLNLESPMKTDIF EEECCCCCCCCCCHH	33.20	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USPL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USPL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USPL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANXA1_HUMAN	ANXA1	physical	19615732
KCRB_HUMAN	CKB	physical	19615732
KINH_HUMAN	KIF5B	physical	19615732
KRT85_HUMAN	KRT85	physical	19615732
6PGD_HUMAN	PGD	physical	19615732
PIP_HUMAN	PIP	physical	19615732
KPYR_HUMAN	PKLR	physical	19615732
ELL_HUMAN	ELL	physical	19615732
ICE1_HUMAN	ICE1	physical	19615732
ANFY1_HUMAN	ANKFY1	physical	19615732
RAGP1_HUMAN	RANGAP1	physical	22878415
COIL_HUMAN	COIL	physical	22878415
SUMO1_HUMAN	SUMO1	physical	22878415
SUMO2_HUMAN	SUMO2	physical	22878415
SUMO3_HUMAN	SUMO3	physical	22878415
SP100_HUMAN	SP100	physical	22878415
ELL_HUMAN	ELL	physical	24413172
COIL_HUMAN	COIL	physical	24413172
ICE1_HUMAN	ICE1	physical	24413172
RPB1_HUMAN	POLR2A	physical	24413172

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.