TTL11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTL11_HUMAN
• UniProt AC: Q8NHH1
• Protein Name: Tubulin polyglutamylase TTLL11
• Gene Name: TTLL11
• Organism: Homo sapiens (Human).
• Sequence Length: 800
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body .
• Protein Description: Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. [PubMed: 22493317 Generates long side-chains (By similarity]
• Protein Sequence: MAAAASVTGRVTWAASPMRSLGLGRRLSLPGPRLDAVTAAVNPSLSDHGNGLGRGTRGSGCSGGSLVADWGGGAAAAAAVALALAPALSTMRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPEEYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRLAGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPTPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSMRIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPRTSCANKLSHPRHTLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	ASVTGRVTWAASPMR CCCCCEEEECCCHHH	14.18	30257219
28	Phosphorylation	LGLGRRLSLPGPRLD CCCCCCCCCCCCCHH	30.61	21857030
38	Phosphorylation	GPRLDAVTAAVNPSL CCCHHHHHEECCCHH	15.60	22210691
44	Phosphorylation	VTAAVNPSLSDHGNG HHEECCCHHCCCCCC	34.99	27732954
46	Phosphorylation	AAVNPSLSDHGNGLG EECCCHHCCCCCCCC	31.72	22210691
56	Phosphorylation	GNGLGRGTRGSGCSG CCCCCCCCCCCCCCC	30.42	22210691
65	Phosphorylation	GSGCSGGSLVADWGG CCCCCCCCEEECCCH	24.16	22210691
95	Phosphorylation	LSTMRRGSSESELAA HHHHHCCCCHHHHHH	29.17	23312004
96	Phosphorylation	STMRRGSSESELAAR HHHHCCCCHHHHHHH	48.22	23312004
98	Phosphorylation	MRRGSSESELAARWE HHCCCCHHHHHHHHH	39.60	22210691
205	Phosphorylation	KGRSCKRSSGHGSGE CCCCCCCCCCCCCCC	26.60	-
215	Phosphorylation	HGSGENGSQRPVTVD CCCCCCCCCCCEEEC	34.30	-
279	Phosphorylation	VNKFPGMTEMVRKIT CCCCCCHHHHHHHHH	27.18	25072903
286	Phosphorylation	TEMVRKITLSRAVRT HHHHHHHHHHHHHHH	23.01	25072903
460	Phosphorylation	GSKRTFSSILCRLSS CCCCHHHHHHHHHHC	18.52	20058876
570	Phosphorylation	KVAVIRDTLRLMDPL HHHHHHHHHHHHHHH		25954137
665	Phosphorylation	LGPTGFRTFIRSCKL CCCCCHHHHHHHCCC		-
669	Phosphorylation	GFRTFIRSCKLSSSS CHHHHHHHCCCCCCC		-
703	Phosphorylation	MTLDQRDSGMCLQAF CCCCCCCCHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTL11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTL11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTL11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TTL11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.