INKA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INKA2_HUMAN
• UniProt AC: Q9NTI7
• Protein Name: PAK4-inhibitor INKA2 {ECO:0000305}
• Gene Name: FAM212B {ECO:0000312|HGNC:HGNC:28045}
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Nucleus .
• Protein Description: Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity..
• Protein Sequence: MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLGSSTKFPSHRSVCGRDLAPLPRTQPHQSCAQQGPERVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGEKGETGGAREPKGEKGQPQELGRRFALTANIFKKFLRSVRPDRDRLLKEKPGWVTPMVPESRTGRSQKVKKRSLSKGSGHFPFPGTGEHRRGENPPTSCPKALEHSPSGFDINTAVWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RLKQELMSMKEVGDG HHHHHHHCCHHHCHH		24719451
51	Phosphorylation	KLLQVQTALEQLEIS HHHHHHHHHHHCCCC		32142685
66	Phosphorylation	GGGPVPGSPEGPRTQ CCCCCCCCCCCCCCC		32142685
89	Phosphorylation	GRGPARPTVCSPSSQ CCCCCCCEEECCCCC		25954137
92	Phosphorylation	PARPTVCSPSSQPSL CCCCEEECCCCCCCC		25954137
94	Phosphorylation	RPTVCSPSSQPSLGS CCEEECCCCCCCCCC		25954137
95	Phosphorylation	PTVCSPSSQPSLGSS CEEECCCCCCCCCCC		21964256
98	Phosphorylation	CSPSSQPSLGSSTKF ECCCCCCCCCCCCCC		21964256
107	Phosphorylation	GSSTKFPSHRSVCGR CCCCCCCCCCCCCCC		25954137
240	Phosphorylation	VTPMVPESRTGRSQK CCCCCCCCCCCCCHH		27251275
242	Phosphorylation	PMVPESRTGRSQKVK CCCCCCCCCCCHHCC		27251275
257	Phosphorylation	KRSLSKGSGHFPFPG CCCCCCCCCCCCCCC		29255136
265	Phosphorylation	GHFPFPGTGEHRRGE CCCCCCCCCCCCCCC		29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INKA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INKA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INKA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
DNSL2_HUMAN	DNASE1L2	physical	26186194
NOSIP_HUMAN	NOSIP	physical	26186194
MRCKB_HUMAN	CDC42BPB	physical	26186194
MRCKA_HUMAN	CDC42BPA	physical	26186194
CE128_HUMAN	CEP128	physical	26186194
CE128_HUMAN	CEP128	physical	28514442
MRCKB_HUMAN	CDC42BPB	physical	28514442
DNSL2_HUMAN	DNASE1L2	physical	28514442
MRCKA_HUMAN	CDC42BPA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.