GIPC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIPC3_HUMAN
• UniProt AC: Q8TF64
• Protein Name: PDZ domain-containing protein GIPC3
• Gene Name: GIPC3
• Organism: Homo sapiens (Human).
• Sequence Length: 312
• Protein Description: Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion..
• Protein Sequence: MEGAAAREARGTETPRASAPPPAPSEPPAAPRARPRLVFRTQLAHGSPTGKIEGFTNVRELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPKSQPFTLRLVQPKRAFDMIGQRSRSSKCPVEAKVTSGRETLRLRSGGAATVEEAPSEFEEEASRKVDDLLESYMGIRDPELASTMVETSKKTASAQEFARCLDSVLGEFAFPDEFVVEVWAAIGEAREACG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	AAREARGTETPRASA HHHHHCCCCCCCCCC	31.00	28555341
14	Phosphorylation	REARGTETPRASAPP HHHCCCCCCCCCCCC	20.22	28555341
18	Phosphorylation	GTETPRASAPPPAPS CCCCCCCCCCCCCCC	42.46	28555341
25	Phosphorylation	SAPPPAPSEPPAAPR CCCCCCCCCCCCCCC	65.91	26657352
47	Phosphorylation	RTQLAHGSPTGKIEG EEEECCCCCCCCCCC	14.93	29214152
51	Ubiquitination	AHGSPTGKIEGFTNV CCCCCCCCCCCCCCH	39.81	-
127	Phosphorylation	DALGLTITDNGAGYA CCCCCEEECCCCCEE	20.41	21406692
133	Phosphorylation	ITDNGAGYAFIKRIK EECCCCCEEEEEECC	9.60	21406692
140	Ubiquitination	YAFIKRIKEGSIINR EEEEEECCCCCCCCC	61.12	-
143	Phosphorylation	IKRIKEGSIINRIEA EEECCCCCCCCCEEE	22.76	-
175	Ubiquitination	CRHYEVAKMLRELPK CCHHHHHHHHHHCCC	43.58	-
187	Phosphorylation	LPKSQPFTLRLVQPK CCCCCCEEEEECCCC	20.04	24719451
221	Phosphorylation	KVTSGRETLRLRSGG EECCCCCEEEEECCC	18.80	27535140
226	Phosphorylation	RETLRLRSGGAATVE CCEEEEECCCEEEHH	46.28	28857561
231	Phosphorylation	LRSGGAATVEEAPSE EECCCEEEHHCCCHH	28.10	28857561
246	Acetylation	FEEEASRKVDDLLES HHHHHHHHHHHHHHH	47.74	30588925
273	Phosphorylation	MVETSKKTASAQEFA HHHHCHHHHCHHHHH	29.58	21406692
275	Phosphorylation	ETSKKTASAQEFARC HHCHHHHCHHHHHHH	35.40	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIPC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIPC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIPC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GIPC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601869: Deafness, autosomal recessive, 15 (DFNB15)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.