EFNA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFNA4_HUMAN
• UniProt AC: P52798
• Protein Name: Ephrin-A4
• Gene Name: EFNA4
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.; Isoform 2: Secreted .
• Protein Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils..
• Protein Sequence: MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	LRHVVYWNSSNPRLL CCEEEEECCCCCCCC	20.20	UniProtKB CARBOHYD
111	Ubiquitination	GHVQFSEKIQRFTPF CCEEHHHHHHHHCCE	42.83	-
154	Ubiquitination	LQVSVCCKERKSESA EEEEEEECCCCCCCC	56.26	-
158	Phosphorylation	VCCKERKSESAHPVG EEECCCCCCCCCCCC	42.90	-
160	Phosphorylation	CKERKSESAHPVGSP ECCCCCCCCCCCCCC	38.68	-
166	Phosphorylation	ESAHPVGSPGESGTS CCCCCCCCCCCCCCC	29.93	-
170	Phosphorylation	PVGSPGESGTSGWRG CCCCCCCCCCCCCCC	53.97	24425749
170	GPI-anchor	PVGSPGESGTSGWRG CCCCCCCCCCCCCCC	53.97	-
173	Phosphorylation	SPGESGTSGWRGGDT CCCCCCCCCCCCCCC	39.62	24425749

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFNA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFNA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFNA4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EFNA4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.