KLD10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLD10_HUMAN
• UniProt AC: Q6PID8
• Protein Name: Kelch domain-containing protein 10
• Gene Name: KLHDC10
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5..
• Protein Sequence: MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIERLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Methylation	GWDRNRRRGGGAAGA CCCCCCCCCCCCCCC	44.89	16187493
25	Phosphorylation	AGAGGGGSGAGGGSG CCCCCCCCCCCCCCC	28.83	29396449
31	Phosphorylation	GSGAGGGSGGSGGRG CCCCCCCCCCCCCCC	43.16	29396449
34	Phosphorylation	AGGGSGGSGGRGTGQ CCCCCCCCCCCCCCC	41.41	29396449
37	Methylation	GSGGSGGRGTGQLNR CCCCCCCCCCCCCCC	42.92	24394787
93	Phosphorylation	HRPPPARSGHRCVAD CCCCCCCCCCCCEEC	40.85	22817900
149	Phosphorylation	HQMGTDGYMPRELAS HHCCCCCCCCHHHHH	13.52	26356563
198	Phosphorylation	YKRWALLSCRGKKPS ECEEEEHHCCCCCCC	11.56	24719451
248	Ubiquitination	TREWTQLKPNNLSCD CCCCHHCCCCCCCCC	35.56	-
305	Ubiquitination	AWEEIATKPHEKIGF CHHHHCCCCHHHCCC	35.04	29967540
394	Phosphorylation	HENKRTGSLFKIWLV ECCCCCCCEEHHHHH	29.98	24719451
404	Phosphorylation	KIWLVVPSLLELAWE HHHHHHHHHHHHHHH	33.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLD10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLD10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLD10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUDC3_HUMAN	NUDCD3	physical	20562859
CUL2_HUMAN	CUL2	physical	20562859
UBP7_HUMAN	USP7	physical	20562859

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.