ADAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADAT1_HUMAN
• UniProt AC: Q9BUB4
• Protein Name: tRNA-specific adenosine deaminase 1
• Gene Name: ADAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 502
• Protein Description: Specifically deaminates adenosine-37 to inosine in tRNA-Ala..
• Protein Sequence: MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	NHEWTLLAAVVKIQS CCCEEEEEEEEECCC	11.00	29967540
50	Phosphorylation	PADKACDTPDKPVQV CCHHHCCCCCCCCEE	33.02	25159151
63	Phosphorylation	QVTKEVVSMGTGTKC EEEEEEECCCCCCCC	19.37	50563631
68	Phosphorylation	VVSMGTGTKCIGQSK EECCCCCCCCCCCHH	23.68	50563623
69	Ubiquitination	VSMGTGTKCIGQSKM ECCCCCCCCCCCHHH	25.79	-
74	Phosphorylation	GTKCIGQSKMRKNGD CCCCCCCHHHCCCCC	24.17	24732914
78	Acetylation	IGQSKMRKNGDILND CCCHHHCCCCCCCCC	62.88	7674273
114	Phosphorylation	AATLKEDSIFVPGTQ HHHHCCCCEECCCCC	21.01	27732954
120	Phosphorylation	DSIFVPGTQKGVWKL CCEECCCCCCCCEEE	22.49	27732954
122	Ubiquitination	IFVPGTQKGVWKLRR EECCCCCCCCEEEEC	56.10	29967540
126	Ubiquitination	GTQKGVWKLRRDLIF CCCCCCEEEECEEEE	29.70	-
174	Phosphorylation	HNSSVEASSNLEAPG CCCCCCCCCCCCCCC	13.27	26074081
175	Phosphorylation	NSSVEASSNLEAPGN CCCCCCCCCCCCCCC	53.10	26074081
191	Phosphorylation	RKCEDPDSPVTKKMR CCCCCCCCCCCCEEE	27.02	23401153
194	Phosphorylation	EDPDSPVTKKMRLEP CCCCCCCCCEEECCC	28.47	30576142
203	Phosphorylation	KMRLEPGTAAREVTN EEECCCCCHHHHHHC	28.05	26074081
208	Ubiquitination	PGTAAREVTNGAAHH CCCHHHHHHCCCCCH	4.14	29967540
216	Ubiquitination	TNGAAHHQSFGKQKS HCCCCCHHHCCCCCC	30.50	23000965
216 (in isoform 2)	Ubiquitination	-	30.50	21890473
223	Phosphorylation	QSFGKQKSGPISPGI HHCCCCCCCCCCCCC	47.51	30266825
227	Phosphorylation	KQKSGPISPGIHSCD CCCCCCCCCCCCCCC	21.87	30266825
232	Phosphorylation	PISPGIHSCDLTVEG CCCCCCCCCCEEEEC	13.86	30266825
236	Phosphorylation	GIHSCDLTVEGLATV CCCCCCEEEECEEEE	11.85	22199227
242	Phosphorylation	LTVEGLATVTRIAPG EEEECEEEEEEECCC	27.70	27080861
244	Phosphorylation	VEGLATVTRIAPGSA EECEEEEEEECCCCC	16.41	27080861
250	Phosphorylation	VTRIAPGSAKVIDVY EEEECCCCCEEEEEE	24.69	22210691
252	Ubiquitination	RIAPGSAKVIDVYRT EECCCCCEEEEEEEC	41.23	-
259	Phosphorylation	KVIDVYRTGAKCVPG EEEEEEECCCCCCCC	24.65	22210691
270	Ubiquitination	CVPGEAGDSGKPGAA CCCCCCCCCCCCCCC	62.35	29967540
273	Ubiquitination	GEAGDSGKPGAAFHQ CCCCCCCCCCCCEEE	44.20	29967540
278	Ubiquitination	SGKPGAAFHQVGLLR CCCCCCCEEEEEEEE	4.03	23000965
294	Phosphorylation	KPGRGDRTRSMSCSD CCCCCCCCCCEECCH	31.66	30576142
296	Phosphorylation	GRGDRTRSMSCSDKM CCCCCCCCEECCHHH	17.90	30576142
298	Phosphorylation	GDRTRSMSCSDKMAR CCCCCCEECCHHHHH	16.24	19845377
300	Phosphorylation	RTRSMSCSDKMARWN CCCCEECCHHHHHHH	32.72	19845377
321	Ubiquitination	ALLMHLLEEPIYLSA HHHHHHHCCCEEEEE	69.00	29967540
335	Ubiquitination	AVVIGKCPYSQEAMQ EEEECCCCCCHHHHH	34.98	29967540
357	Ubiquitination	QNVSALPKGFGVQEL CCHHHCCCCCCCCHH	68.66	29967540
365	Ubiquitination	GFGVQELKILQSDLL CCCCCHHHHHHHHHH	40.39	23000965
365 (in isoform 1)	Ubiquitination	-	40.39	21890473
383	Ubiquitination	SRSAVQAKRADSPGR HHHHHHHHHCCCCCC	30.90	29967540
422	Ubiquitination	FPQGTTKKTIGSLQA CCCCCCCCCHHHHHH	43.19	29967540
423	Phosphorylation	PQGTTKKTIGSLQAR CCCCCCCCHHHHHHH	31.93	23312004
426	Phosphorylation	TTKKTIGSLQARSQI CCCCCHHHHHHHHHH	17.29	23312004
431	Phosphorylation	IGSLQARSQISKVEL HHHHHHHHHHCHHHH	34.58	50563639
434	Phosphorylation	LQARSQISKVELFRS HHHHHHHCHHHHHHH	24.02	50563655
447	Phosphorylation	RSFQKLLSRIARDKW HHHHHHHHHHHHCCC	31.88	46159517
465	Phosphorylation	LRVQKLDTYQEYKEA EEEEECHHHHHHHHH	37.22	26074081
466	Phosphorylation	RVQKLDTYQEYKEAA EEEECHHHHHHHHHH	10.06	26074081
469	Phosphorylation	KLDTYQEYKEAASSY ECHHHHHHHHHHHHH	9.90	26074081
470	Ubiquitination	LDTYQEYKEAASSYQ CHHHHHHHHHHHHHH	39.87	29967540
476	Phosphorylation	YKEAASSYQEAWSTL HHHHHHHHHHHHHHH	14.10	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADAT1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ADAT1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.