GP161_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GP161_HUMAN
• UniProt AC: Q8N6U8
• Protein Name: G-protein coupled receptor 161
• Gene Name: GPR161
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is i
• Protein Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity)..
• Protein Sequence: MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MSLNSSLSCRK ----CCCCHHHHHHH	23.42	UniProtKB CARBOHYD
15	N-linked_Glycosylation	SCRKELSNLTEEEGG HHHHHHHCCCHHHCC	64.70	UniProtKB CARBOHYD
43 (in isoform 4)	Phosphorylation	-	4.24	23663014
46 (in isoform 4)	Phosphorylation	-	2.36	23663014
47 (in isoform 4)	Phosphorylation	-	3.46	23663014
48 (in isoform 4)	Phosphorylation	-	2.02	23663014
49 (in isoform 4)	Phosphorylation	-	1.78	23663014
57	Phosphorylation	VTLYKKSYLLTLSNK EEEECCHHHHHHCCC	18.01	-
226	Phosphorylation	ARKVHCGTVVIVEED HCCCCCCEEEEECCC	19.59	-
244	Phosphorylation	TGRKNSSTSTSSSGS HCCCCCCCCCCCCCC	35.53	30631047
245	Phosphorylation	GRKNSSTSTSSSGSR CCCCCCCCCCCCCCC	28.39	30631047
246	Phosphorylation	RKNSSTSTSSSGSRR CCCCCCCCCCCCCCC	32.49	22210691
247	Phosphorylation	KNSSTSTSSSGSRRN CCCCCCCCCCCCCCH	23.44	22210691
249	Phosphorylation	SSTSTSSSGSRRNAF CCCCCCCCCCCCHHH	40.32	-
251	Phosphorylation	TSTSSSGSRRNAFQG CCCCCCCCCCHHHHH	29.98	-
344	Phosphorylation	GMCFGDRYYREPFVQ HHHHCCHHHCCHHHH	16.18	-
345	Phosphorylation	MCFGDRYYREPFVQR HHHCCHHHCCHHHHH	14.92	-
360	Phosphorylation	QRTSRLFSISNRITD HHHHHHHHCHHHHHH	29.69	23403867
362	Phosphorylation	TSRLFSISNRITDLG HHHHHHCHHHHHHCC	20.89	23403867
380	Phosphorylation	HLTALMAGGQPLGHS HHHHHHCCCCCCCCC	22.70	27251275
429	Phosphorylation	TCPPKRRSSVTFEDE CCCCCCCCCCCCHHH	32.94	29255136
430	Phosphorylation	CPPKRRSSVTFEDEV CCCCCCCCCCCHHHH	24.30	29255136
432	Phosphorylation	PKRRSSVTFEDEVEQ CCCCCCCCCHHHHHH	24.21	29255136
441	Ubiquitination	EDEVEQIKEAAKNSI HHHHHHHHHHHHCCC	40.78	-
450	Phosphorylation	AAKNSILHVKAEVHK HHHCCCEEHHHHHHH	19.84	27251275
490	Phosphorylation	ALPGVLVTARTVPGG CCCEEEEEEEEECCC	13.27	-
493	Phosphorylation	GVLVTARTVPGGGFG EEEEEEEEECCCCCC	28.70	-
517	Phosphorylation	SQRLQLQSIEEGDVL CCCEECCCCCCCCCC	40.33	30266825
537	Phosphorylation	--------------- ---------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GP161_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GP161_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GP161_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAP1_HUMAN	PRKAR1B	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
KAPCG_HUMAN	PRKACG	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
UB2Q1_HUMAN	UBE2Q1	physical	28514442
KAPCA_HUMAN	PRKACA	physical	28514442
UBP12_HUMAN	USP12	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
RTN4_HUMAN	RTN4	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.