dbPTM

NET4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NET4_HUMAN
UniProt AC	Q9HB63
Protein Name	Netrin-4
Gene Name	NTN4
Organism	Homo sapiens (Human).
Sequence Length	628
Subcellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane . Major component.
Protein Description	May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants..
Protein Sequence	MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	N-linked_Glycosylation	ADTTCGQNATELYCF CCCCCCCCCEEEEEE	33.83	UniProtKB CARBOHYD
163	N-linked_Glycosylation	PYKYFATNCSATFGL CCEEEECCCCCCCCC	17.83	UniProtKB CARBOHYD
222	Phosphorylation	VQEQLKITNLRVQLL HHHHHHHCHHHHHHH	26.98	-
353	N-linked_Glycosylation	NVWEASGNRSGGVCD EEEECCCCCCCCCCC	32.23	UniProtKB CARBOHYD
483	N-linked_Glycosylation	PDFRPVHNKSEPAWE CCCCCCCCCCCCCCC	50.19	UniProtKB CARBOHYD
529	Ubiquitination	MKYSYVLKIKILSAH CEEEEEEEEEEEECC	31.73	-
555	Phosphorylation	IKKVLKSTKLKIFRG HHHHHHHCCEEEECC	38.52	24719451
606	Phosphorylation	KLIVNMKSFVQHWKP CEEEEHHHHHHHHCH	21.63	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NET4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NET4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NET4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NET4_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NET4_HUMAN

Related Literatures of Post-Translational Modification