TT39C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TT39C_HUMAN
• UniProt AC: Q8N584
• Protein Name: Tetratricopeptide repeat protein 39C
• Gene Name: TTC39C
• Organism: Homo sapiens (Human).
• Sequence Length: 583
• Protein Sequence: MAGSEQQRPRRRDDGDSDAAAAAAAPLQDAELALAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCESEEAGVIETIKNKIKKNVDVRKSAPSMVDRLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKKLTEESLTSDAANDNHIVAEGVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPLATLALLWYHTVVRPFFALDGSDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVCQGATGDVDGAQIVFKEVQKLFKRKNNQIEQFSVKKAERFRKQTPTKALCVLASIEVLYLWKALPNCSFPNLQRMSQACHEVDDSSVVGLKYLLLGAIHKCLGNSEDAVQYFQRAVKDELCRQNNLYVQPYACYELGCLLLDKPETVGRGRALLLQAKEDFSGYDFENRLHVRIHAALASLRELVPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	30.16	29507054
6 (in isoform 2)	Phosphorylation	-	46.40	29507054
53	Ubiquitination	RESDQLFKQYRNHSP HHHHHHHHHHHCCCC	55.82	-
77	Phosphorylation	SFLNAMMTFEEEKMQ HHHHHHHCCCHHHHH	18.14	29507054
91	Acetylation	QLACDDLKTTEKLCE HHHHCHHHHHHHHHH	61.47	26051181
109	Ubiquitination	AGVIETIKNKIKKNV CCHHHHHHHHHHHCC	60.66	-
167	Ubiquitination	WILRKAWKIYNKCYL HHHHHHHHHHHHHHC	39.92	-
185	Ubiquitination	ALQELYQKKLTEESL HHHHHHHHHCCHHHC	35.87	-
186	Ubiquitination	LQELYQKKLTEESLT HHHHHHHHCCHHHCC	45.15	-
188	Phosphorylation	ELYQKKLTEESLTSD HHHHHHCCHHHCCCC	46.73	28555341
193	Phosphorylation	KLTEESLTSDAANDN HCCHHHCCCCCCCCC	33.56	28555341
301	Ubiquitination	KAGLDEAKEILLKKE CCCHHHHHHHHHHHH	43.15	-
355	Acetylation	QREIQHVCLYEIGWC HHHHCCEEHHHCCCC	2.92	19608861
358	Acetylation	IQHVCLYEIGWCSMI HCCEEHHHCCCCCEE	23.29	19608861
416	Acetylation	IVFKEVQKLFKRKNN HHHHHHHHHHHHCCC	62.15	19608861
419	Acetylation	KEVQKLFKRKNNQIE HHHHHHHHHCCCCCC	73.27	19608861
431	Ubiquitination	QIEQFSVKKAERFRK CCCCHHHHHHHHHHC	45.10	-
487	Acetylation	DSSVVGLKYLLLGAI HHHHHHHHHHHHHHH	28.11	7409433
513	Ubiquitination	QYFQRAVKDELCRQN HHHHHHHHHHHHHCC	44.49	-
513	Acetylation	QYFQRAVKDELCRQN HHHHHHHHHHHHHCC	44.49	27452117
576	Phosphorylation	RIHAALASLRELVPQ HHHHHHHHHHHHCCC	28.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TT39C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TT39C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TT39C_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TT39C_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-416, AND MASS SPECTROMETRY.
PubMed: 19608861