EGFLA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGFLA_HUMAN
• UniProt AC: Q63HQ2
• Protein Name: Pikachurin
• Gene Name: EGFLAM
• Organism: Homo sapiens (Human).
• Sequence Length: 1017
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Cell junction, synapse . Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells. Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic ter
• Protein Description: Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity)..
• Protein Sequence: MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECGNYCLNTIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Acetylation	SLRAAIRKPGKVGPP HHHHHHCCCCCCCCC	52.59	19413330
47	N-linked_Glycosylation	DIKLGALNCTAFSIQ EEEECCCCCEEEEEE	22.13	UniProtKB CARBOHYD
50	Ubiquitination	LGALNCTAFSIQWKM ECCCCCEEEEEEECC	9.82	22817900
54	Ubiquitination	NCTAFSIQWKMPRHP CCEEEEEEECCCCCC	32.32	22817900
55	Ubiquitination	CTAFSIQWKMPRHPG CEEEEEEECCCCCCC	9.39	21890473
55 (in isoform 4)	Ubiquitination	-	9.39	21890473
73	Ubiquitination	LGYTVFYSEVGADKS CEEEEEEECCCCCHH	17.84	21963094
80	Phosphorylation	SEVGADKSLQEQLHS ECCCCCHHHHHHHHC	35.51	27251275
87	Phosphorylation	SLQEQLHSVPLSRDI HHHHHHHCCCCCCCC	33.74	29449344
91	Phosphorylation	QLHSVPLSRDIPTTE HHHCCCCCCCCCCCH	23.10	29449344
113	Phosphorylation	PGTEYRVSIAAYSQA CCCEEEEEEEEECCC	9.49	24719451
117	Phosphorylation	YRVSIAAYSQAGKGR EEEEEEEECCCCCCC	7.72	24719451
126	Phosphorylation	QAGKGRLSSPRHVTT CCCCCCCCCCCCEEE	36.61	17081983
127	Phosphorylation	AGKGRLSSPRHVTTL CCCCCCCCCCCEEEC	30.46	25137130
200	Phosphorylation	HERIQMDSMVIKGLD HHHHCCCCEEECCCC	15.03	27251275
221	Phosphorylation	FAVRAMNSHGPSPRS HHHHHHHCCCCCCCC	19.41	25002506
225	Phosphorylation	AMNSHGPSPRSWPSD HHHCCCCCCCCCCHH	37.22	25002506
228	Phosphorylation	SHGPSPRSWPSDIIR CCCCCCCCCCHHHHH	46.88	25002506
231	Phosphorylation	PSPRSWPSDIIRTLC CCCCCCCHHHHHHHC	34.87	25002506
273	Phosphorylation	DDLDLDISFEEVKPL CCCCCCCCEEEEECC	26.69	-
283	Phosphorylation	EVKPLPATKGGNKKF EEECCCCCCCCCCEE	28.43	-
284	Ubiquitination	VKPLPATKGGNKKFL EECCCCCCCCCCEEE	67.91	22817900
288	Ubiquitination	PATKGGNKKFLVESK CCCCCCCCEEEEEEE	48.45	22817900
289 (in isoform 2)	Ubiquitination	-	48.18	21890473
289 (in isoform 1)	Ubiquitination	-	48.18	21890473
289	Ubiquitination	ATKGGNKKFLVESKK CCCCCCCEEEEEEEE	48.18	22817900
294	Phosphorylation	NKKFLVESKKMSISN CCEEEEEEEECCCCC	30.05	25404012
298	Phosphorylation	LVESKKMSISNPKTI EEEEEECCCCCCCCH	31.57	-
312	O-linked_Glycosylation	ISRLIPPTSASLPVT HHHHCCCCCCCCCCE	31.41	OGP
319	O-linked_Glycosylation	TSASLPVTTVAPQPI CCCCCCCEEECCCCC	17.39	OGP
446	Phosphorylation	SLAIIRRSLQFRFNC HHHHHHHHHCEEECC	19.37	29970186
473	Phosphorylation	IKLGGWHTVMLYRDG EEECCEEEEEEEECC	10.91	22468782
527	Ubiquitination	WLVRATGTNRGFQGC EEHHHCCCCCCCCHH	19.86	29967540
554	Acetylation	MRPWPLGKALSGADV CCCCCCCCCCCCCCC	54.56	19819087
615	Phosphorylation	TIPQFRESLRSYAAT EHHHHHHHHHHHCCC	25.48	22210691
631	Phosphorylation	WPLEPQHYLSFMEFE CCCCCHHEEEEEEEE	9.97	22210691
633	Phosphorylation	LEPQHYLSFMEFEIT CCCHHEEEEEEEEEE	18.51	22210691
696	Ubiquitination	PLTLGNWHELRVSRT CCCCCCCEEEEEEEE	28.36	21963094
703	Phosphorylation	HELRVSRTAKNGILQ EEEEEEEECCCCCEE	34.18	22210691
715	Acetylation	ILQVDKQKIVEGMAE CEEECHHHHHHHHHC	55.23	19828367
729	Acetylation	EGGFTQIKCNTDIFI CCCCCEEEECCCEEE	16.18	7491961
749	Phosphorylation	YDDVKKNSGVLKPFS HHHHHHCCCCCCCCC	38.88	28258704
761	Ubiquitination	PFSGSIQKIILNDRT CCCCCEEEEEECCCE	30.00	29967540
930	Ubiquitination	GRWHRVKAVRDGQSG CCEEEEEEEECCCCC	9.94	21963094
938	Ubiquitination	VRDGQSGKITVDDYG EECCCCCEEEECCCH	40.21	21963094
940	Phosphorylation	DGQSGKITVDDYGAR CCCCCEEEECCCHHC	22.74	23403867
944	Phosphorylation	GKITVDDYGARTGKS CEEEECCCHHCCCCC	14.28	23403867
948	Phosphorylation	VDDYGARTGKSPGMM ECCCHHCCCCCCCCC	48.72	23403867
951	Phosphorylation	YGARTGKSPGMMRQL CHHCCCCCCCCCCEE	28.20	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EGFLA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGFLA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGFLA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EGFLA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.