RIPL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIPL1_HUMAN
• UniProt AC: Q5EBL4
• Protein Name: RILP-like protein 1
• Gene Name: RILPL1
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
• Protein Description: Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution..
• Protein Sequence: MEEERGSALAAESALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRLERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLSHKDVNFSEEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEPETEPVGEESISDAEKVAMDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQPESGIKRLFSFFSRDKKRLANTQRNVHIQESFGQWANTHRDDGYTEQGQEALQHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEERGSALAAESA -CHHHHHHHHHHHHH	26.74	-
47	S-nitrosylation	RVIDQHGCEAIARLM HHHHHHHHHHHHHHH	2.75	-
47	S-nitrosocysteine	RVIDQHGCEAIARLM HHHHHHHHHHHHHHH	2.75	-
103	Ubiquitination	EKERKHQKELELVED HHHHHHHHHHHHHHH	65.08	-
145	Phosphorylation	SHKDVNFSEEEFQKH CCCCCCCCHHHHHHH	38.60	22199227
151	Ubiquitination	FSEEEFQKHEGMSER CCHHHHHHHCCCCHH	49.28	-
235	Phosphorylation	ELEADLQTKEQEMGS HHHCHHHHHHHHHHH	43.79	20068231
242	Phosphorylation	TKEQEMGSLRAELGK HHHHHHHHHHHHHHH	17.24	26270265
249	Ubiquitination	SLRAELGKLRERLQG HHHHHHHHHHHHHCC	57.93	-
259	Phosphorylation	ERLQGEHSQNGEEEP HHHCCCCCCCCCCCC	22.49	25159151
268	Phosphorylation	NGEEEPETEPVGEES CCCCCCCCCCCCCCC	57.20	23403867
275	Phosphorylation	TEPVGEESISDAEKV CCCCCCCCCCHHHHH	24.08	23403867
277	Phosphorylation	PVGEESISDAEKVAM CCCCCCCCHHHHHHH	39.79	23403867
287	Ubiquitination	EKVAMDLKDPNRPRF HHHHHCCCCCCCCCC	67.86	-
311	Phosphorylation	HERNELKSKVFLLQE HHHHHHHHHHHHHHH	46.83	-
322	Phosphorylation	LLQEELAYYKSEEME HHHHHHHHHCCHHHH	24.85	-
323	Phosphorylation	LQEELAYYKSEEMEE HHHHHHHHCCHHHHH	11.48	-
345	Phosphorylation	PPIAHPRTSPQPESG CCCCCCCCCCCCCCH	49.57	28176443
346	Phosphorylation	PIAHPRTSPQPESGI CCCCCCCCCCCCCHH	23.87	25159151
351	Phosphorylation	RTSPQPESGIKRLFS CCCCCCCCHHHHHHH	53.13	23403867
354	Ubiquitination	PQPESGIKRLFSFFS CCCCCHHHHHHHHHH	46.72	-
358	Phosphorylation	SGIKRLFSFFSRDKK CHHHHHHHHHHHCHH	29.94	29514088
361	Phosphorylation	KRLFSFFSRDKKRLA HHHHHHHHHCHHHHH	37.24	29978859
379	Phosphorylation	RNVHIQESFGQWANT CCHHHHHHCHHHHHH	20.50	27251275
392	Phosphorylation	NTHRDDGYTEQGQEA HHCCCCCCCHHHHHH	17.69	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIPL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIPL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIPL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RIPL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.